Detalhe da pesquisa
1.
Pharmacokinetics, Metabolism, and Excretion of [14C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans.
Drug Metab Dispos
; 47(3): 340-349, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30541878
2.
Elucidation of N 1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters.
Drug Metab Dispos
; 47(11): 1270-1280, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31511257
3.
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.
Pharm Res
; 36(4): 55, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30790061
4.
Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys.
Xenobiotica
; 49(9): 1086-1096, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30351177
5.
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.
Xenobiotica
; 49(8): 961-969, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124356
6.
Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
Drug Metab Dispos
; 46(5): 667-679, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29358184
7.
Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.
Pharm Res
; 35(7): 138, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29748935
8.
Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex.
Int J Mol Sci
; 19(6)2018 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867033
9.
Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents.
Drug Metab Dispos
; 45(3): 336-341, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27974381
10.
Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers.
Pharm Res
; 34(8): 1601-1614, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28550384
11.
In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01.
Int J Mol Sci
; 18(4)2017 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28338626
12.
Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.
Drug Metab Dispos
; 44(10): 1608-16, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469000
13.
IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function.
Biochem Biophys Res Commun
; 444(3): 360-4, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24462863
14.
Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
J Biol Chem
; 286(36): 31409-17, 2011 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733845
15.
IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells.
Biochem Biophys Res Commun
; 423(3): 553-6, 2012 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22683334
16.
Long-term effects of the trehalase inhibitor trehazolin on trehalase activity in locust flight muscle.
J Exp Biol
; 213(Pt 22): 3852-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21037064
17.
Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion.
J Pharm Sci
; 108(8): 2756-2764, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905707
18.
Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation.
J Antibiot (Tokyo)
; 70(1): 84-89, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27328866
19.
Identification and biological activity of ogipeptins, novel LPS inhibitors produced by marine bacterium.
J Antibiot (Tokyo)
; 70(1): 79-83, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27381520
20.
Comparison between properties of 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) phosphorothioate oligonucleotides and N3'-P5' thiophosphoramidate oligonucleotides.
Nucleosides Nucleotides Nucleic Acids
; 25(3): 231-42, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16629117