Detalhe da pesquisa
1.
Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.
J Am Chem Soc
; 138(23): 7268-71, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27244042
2.
Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host.
PLoS Pathog
; 9(2): e1003180, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23468624
3.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
ChemMedChem
; 17(22): e202200393, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129427
4.
Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.
Eur J Med Chem
; 211: 113065, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33360801
5.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep
; 11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
6.
Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty.
Pharmaceuticals (Basel)
; 13(2)2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32028743
7.
Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.
ACS Infect Dis
; 6(4): 613-628, 2020 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32078764
8.
Structure-Activity and Structure-Toxicity Relationships of Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity.
ChemMedChem
; 14(9): 912-926, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30664827
9.
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
Commun Biol
; 2: 166, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31069275
10.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
11.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
Science
; 365(6456)2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467193
12.
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies.
J Cheminform
; 10(1): 6, 2018 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29464421
13.
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Eur J Med Chem
; 158: 801-813, 2018 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30245402
14.
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Science
; 362(6419)2018 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30523084
15.
Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity.
ChemMedChem
; 12(19): 1627-1636, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28812327
16.
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.
J Med Chem
; 60(15): 6721-6732, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28696697
17.
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
ACS Infect Dis
; 2(4): 281-293, 2016 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275010
18.
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
J Med Chem
; 59(21): 9890-9905, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748596
19.
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.
ACS Cent Sci
; 2(10): 687-701, 2016 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27800551
20.
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi.
Microbes Infect
; 15(12): 775-87, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23774695