Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.

BACKGROUND: In B-cell precursor acute lymphoblastic leukaemia (B-ALL), the identification of additional genetic alterations associated with poor prognosis is still of importance. We determined the frequency and prognostic impact of somatic mutations in children and adult cases with B-ALL treated with Spanish PETHEMA and SEHOP protocols. METHODS: Mutational status of hotspot regions of TP53, JAK2, PAX5, LEF1, CRLF2 and IL7R genes was determined by next-generation deep sequencing in 340 B-ALL patients (211 children and 129 adults). The associations between mutation status and clinicopathological features at the time of diagnosis, treatment outcome and survival were assessed. Univariate and multivariate survival analyses were performed to identify independent prognostic factors associated with overall survival (OS), event-free survival (EFS) and relapse rate (RR). RESULTS: A mutation rate of 12.4% was identified. The frequency of adult mutations was higher (20.2% vs 7.6%, P=0.001). TP53 was the most frequently mutated gene (4.1%), followed by JAK2 (3.8%), CRLF2 (2.9%), PAX5 (2.4%), LEF1 (0.6%) and IL7R (0.3%). All mutations were observed in B-ALL without ETV6-RUNX1 (P=0.047) or BCR-ABL1 fusions (P<0.0001). In children, TP53mut was associated with lower OS (5-year OS: 50% vs 86%, P=0.002) and EFS rates (5-year EFS: 50% vs 78.3%, P=0.009) and higher RR (5-year RR: 33.3% vs 18.6% P=0.037), and was independently associated with higher RR (hazard ratio (HR)=4.5; P=0.04). In adults, TP53mut was associated with a lower OS (5-year OS: 0% vs 43.3%, P=0.019) and a higher RR (5-year RR: 100% vs 61.4%, P=0.029), whereas JAK2mut was associated with a lower EFS (5-year EFS: 0% vs 30.6%, P=0.035) and a higher RR (5-year RR: 100% vs 60.4%, P=0.002). TP53mut was an independent risk factor for shorter OS (HR=2.3; P=0.035) and, together with JAK2mut, also were independent markers of poor prognosis for RR (TP53mut: HR=5.9; P=0.027 and JAK2mut: HR=5.6; P=0.036). CONCLUSIONS: TP53mut and JAK2mut are potential biomarkers associated with poor prognosis in B-ALL patients.

Sustained response after discontinuation of short-and medium-term treatment with eltrombopag in patients with immune thrombocytopenia.

Eltrombopag is effective and safe in chronic immune thrombocytopenia (ITP) patients not responding to previous therapy. However, when eltrombopag is discontinued, platelet counts usually return to baseline within 2 weeks. Here, we describe the clinical characteristics of the, to the best of our knowledge, largest case series of patients with ITP, who presented sustained responses after discontinuing eltrombopag (n = 12). The median time from diagnosis to eltrombopag initiation was 24 months (range, 1-480). The median number of prior therapies was 5 (range, 1-7), and the median duration of eltrombopag treatment was 5 months (range, 1-13). Three patients received eltrombopag for only 1 month. The treatment was well-tolerated. The median (range) follow-up of this case series was of 7 months (6-20), during which all patients maintained a safe platelet count without the need for anti-ITP treatment. The communication of such cases may support the conduction of new studies to investigate which predictive factors could identify ITP patients with sustained responses after discontinuing eltrombopag without additional therapy. The need of long-term use of eltrombopag should be re-examined.

Genomic analysis of clonal eosinophils by CGH arrays reveals new genetic regions involved in chronic eosinophilia.

To assess the presence of genetic imbalances in patients with myeloproliferative neoplasms (MPNs), 38 patients with chronic eosinophilia were studied by array comparative genomic hybridization (aCGH): seven had chronic myelogenous leukaemia (CML), BCR-ABL1 positive, nine patients had myeloproliferative neoplasia Ph- (MPN-Ph-), three had a myeloid neoplasm associated with a PDGFRA rearrangement, and the remaining two cases were Lymphoproliferative T neoplasms associated with eosinophilia. In addition, 17 patients had a secondary eosinophilia and were used as controls. Eosinophilic enrichment was carried out in all cases. Genomic imbalances were found in 76% of all MPN patients. Losses on 20q were the most frequent genetic abnormality in MPNs (32%), affected the three types of MPN studied. This study also found losses at 11q13.3 in 26% of patients with MPN-Ph- and in 19p13.11 in two of the three patients with an MPN associated with a PDGFRA rearrangement. In addition, 29% of patients with CML had losses on 8q24. In summary, aCGH revealed clonality in eosinophils in most MPNs, suggesting that it could be a useful technique for defining clonality in these diseases. The presence of genetic losses in new regions could provide new insights into the knowledge of these MPN associated with eosinophilia.

Investigating the effect of hot and cold polyurethane foam on reducing whole body vibration of forklift operators.

BACKGROUND: Vibration is one of the harmful factors for forklift drivers. The use of non- standard seats and not paying attention to how the seats are maintained can be affected by the amount of vibration transmitted to the person. OBJECTIVE: This study investigates the amount of vibration transmitted from the forklift and the effect of different types of polyurethane foam in reducing the vibration transmitted from the forklift seat. METHODS: This descriptive-analytical study was performed on 38 forklifts in 4 diesel models with the same weight class. The amount of vibration transmitted from forklift seats according to ISO2631 standard, taking into account the effect of various factors such as foam type (hot and cold), thickness (6-12 cm), load and year Function was measured. The amount of vibration caused by the forklift on the seat and under the seat was evaluated using ISO7096 standard. RESULTS: The average total vibration of the whole body in all foams in no-load mode is more than with load. The transmission vibration of cold polyurethane foam is less than that of hot polyurethane foam. With increasing thickness, the efficiency of cold polyurethane foam increases by 12 cm and in the loaded state 40.63% and in the unloaded state 49.58% in reducing the vibration transmitted to drivers. CONCLUSION: The results of this study show that cold foam has better effectiveness and efficiency than hot polyurethane foam. Also, the thicker the foam, the less vibration is transmitted to the driver.

Safety and efficacy of splenectomy in over 65-yrs-old patients with immune thrombocytopenia.

AIM: Few studies specifically focus on elderly splenectomized immune thrombocytopenia (ITP) patients. Older patients with ITP and excellent health are often excluded from surgery splenectomy. We aimed to compare the safety and efficacy of splenectomy in elderly and non-elderly ITP patients and to examine the effect of age on therapeutic response. MATERIAL AND METHODS: We carried out a retrospective analysis of a series of 218 patients who had undergone splenectomy for ITP. We compared the data from the elderly group (≥65 yrs, 57 patients) with the young group (<65 yrs, 162 patients). RESULTS: Surgical technique (laparoscopy or open laparotomy splenectomy) was comparable between the two age groups. The adjusted risk of major bleeding following splenectomy for elderly patients was three times that for young patients (OR 3.05, 95% CI: 1.44-6.52). The median duration of postoperative hospital stay was longer for elderly than for young patients (8 d vs. 4 d, P < 0.001). However, we identified a subgroup of elderly ITP patients, those aged between 65 and 70 yrs who had undergone laparoscopic splenectomy, with a low risk of postoperative complications. Of the 218 patients, 89% achieved a favorable response to splenectomy. A favorable response was significantly less common in elderly than in young people (79% vs. 92%, P = 0.005). However, we observed an acceptable long-term control of ITP in the elderly group, in which the probability of maintaining response for 14 yrs after splenectomy was 56%. CONCLUSIONS: Patients aged ≥65 yrs experienced negative effects on safety and efficacy outcomes of splenectomy for ITP, but further studies are needed to identify predictors of postsplenectomy outcomes in this group.

Providing an approach to analyze the risk of central oxygen tanks in hospitals during the COVID-19 pandemic.

The central oxygen unit of hospitals is considered a high-risk unit, requiring high safety standards to maintain the integrity of the system during the COVID-19 pandemic. The linear reasoning assumption of conventional risk analysis methods cannot adequately describe these modern systems, which are characterized by tight connections and complex interactions between technical, human, and organizational aspects. Therefore, this study presents a new and comprehensive approach to oxygen tanks in hospitals during the COVID-19 pandemic. In this study, trapezoidal fuzzy numbers were used to calculate failure rates. After determining the probability of basic events (BEs), intermediate events (IE), and top event (TE) with fuzzy logic and transferring it into Bayesian Network (BN), deductive and inductive reasoning, and sensitivity analysis were performed using RoV in GeNIe software. The results of the case study showed that the IE of "Human Error" had the highest probability of fuzzy fault tree (FFT) and the probability of oxygen leakage was lower using FBN than FFT. According to the results, BE16 (failure to use standard and updated instructions) and BE12 (defects in the inspection and testing program of tank devices) had the highest posterior probability, while based on the FFT results, BE4 (defects in the external coating system of the tank) and, BE3 (Corrosive environment (acidity state)) had the least probability. According to the sensitivity analysis, basic events 10, 11, and 16 were the most important in the oxygen leakage event with a very small difference, which was almost in line with the results of posterior FBN (FBNPO). Updating the existing guidelines, fixing defects in the inspection of all types of tank gauges, and testing related equipment can greatly help the reliability of these tanks. Root cause analysis of these events provides opportunities for prevention and emergency response in critical situations, such as the COVID-19 pandemic.

Incidence and clinical characteristics of myeloproliferative neoplasms displaying a PDGFRB rearrangement.

OBJECTIVES: The myeloproliferative neoplasms displaying a PDGFRB rearrangement are rare diseases derived from a haematopoietic stem cell. The goals of the study were to assess the incidence of these disorders and to define the clinical and biological characteristics as well as the response to the imatinib therapy. METHODS: A total of 556 patients with myeloproliferative neoplasms were studied by means of molecular cytogenetics. RESULTS: The incidence of myeloproliferative neoplasms (MPN) with PDGFRB rearrangement was low (10 cases, 1.8% of all MPN). Most of the patients showed moderate anaemia (median Hb was 10.0 gr/dL; range from 7.5 to 13 g/dL), leukocytosis (median white blood cells was 21.7 × 10(9) /L with a range from 4 to 43 × 10(9) /L) and eosinophilia (median circulating eosinophils was 2.4 × 10(9) /L with a range of 1.1-5.7 × 10(9) /L) with a median of bone marrow infiltration cells displaying PDGFRB rearrangement of 55% (range, 37-85%). In three cases, a t(5;12) was observed while two patients showed rearrangements of 17q21 region. In two cases, a del(5)(q31) was observed. Most of the patients responded to standard dosage of imatinib, and the response was maintained in the time in those patients with a follow-up higher than 9 years. CONCLUSIONS: The incidence of patients with PDGFRB rearrangement is low. These patients showed leukocytosis with eosinophilia and anaemia. The efficacy of imatinib therapy in patients showing PDGFRB rearrangement is high. For this reason, in all patients with MPN without any other molecular aberration, PDGFRB rearrangement should be ascertained.

Prevalence of job burnout in Iranian nurses: A systematic review and meta-analysis.

BACKGROUND: Nurses experience many job tensions, which lead to job burnout. The consequences of nurses' job burnout include absenteeism, reduced quality of patient care, interpersonal conflicts with colleagues, physical and mental problems, reluctance to provide care with patients, and quitting the job. OBJECTIVE: The present study aimed to investigate the prevalence of job burnout among nurses in Iran using a meta-analysis method. METHOD: The study was conducted through a meta-analysis method based on the PRISMA checklist. An unlimited search was conducted until 2020 to access the Persian and English papers in national databases, including Medlib, SID, Iranmedex, and Magiran, and databases including Cochrane, Science-Direct, PubMed, Scopus, and Web of Science. The keywords were "job burnout, nurse, and Iran." The data were searched and extracted by two researchers independently. All analyses were performed using version 2.0 of the Comprehensive Meta-Analysis (CMA) software. RESULTS: The prevalence of job burnout was investigated in 14 papers with a sample size of 2271 individuals with an average age of 31.44 years old, and a confidence interval of 55% (44-66%). Fars province, with 89.2%, had the highest, and Zanjan province, with 25.9%, experienced the lowest prevalence of job burnout. The overall prevalence of job burnout was 44% in males and 66% in females so that the highest prevalence was in women. CONCLUSION: The prevalence of job burnout in nurses was high in some areas of Iran. A special attention by managers is needed in this field because of the several roles played by the nurses in the healthcare system and the improvement of public health. Implementation of plans to reduce the job burnout and to improve the mental health of nurses by reducing work hours, giving more opportunities to them to express their opinion(s) in amount of salary and benefits, and creating better working conditions are recommended.

Quantitative evaluation of chemical fume hoods performance by CO2 tracer gas.

BACKGROUND: Various chemical substances and carcinogens have been presented in medical sciences universities' educational and research laboratories. For this purpose a suitable ventilation system had to be implemented to ensure the correct operation of the hoods. OBJECTIVE: To evaluate the performance of laboratory chemical fume hoods of the University of Medical Sciences using a novel quantitative method. METHODS: In this study, 43 chemical fume hoods were investigated in the laboratories of the University of Medical Sciences. The technical specifications of the hoods and their compliance with the standard have been investigated. The hoods face velocity was measured using a thermal anemometer. Quantitative evaluation was performed using the new method of CO2 tracer gas and the results were analyzed using SPSS software version 19. FINDINGS: The hoods presented both favorable and unfavorable results in terms of technical specifications and location. The results showed 50.2% of the hoods have visible leakage. Hood face velocity was not suitable for any of the hoods in the case fully open.when half open only 16.3% of the hoods and in the case of 25% open face, 34.9% of the hoods had a good velocity. Most hoods have CO2 leakage even at small amounts. CONCLUSIONS: the unsuitable performance of the hoods is mainly due to the unsuitability of the fans, furthermore investigation and correction of technical problems are required. The new quantitative method is a suitable method for routine evaluating chemical fume hoods and can replace the SF6 gas tracer method.

Investigation of occupational fatigue and safety climate among nurses using the structural equation model.

BACKGROUND: Nursing is associated with many stressful situations that can lead to fatigue, reduced efficiency, and physical and mental illness. Safety climate is one of the most important indicators of safety management performance assessment that assesses employees' attitudes towards safety issues. OBJECTIVE: The purpose of this study was to investigate the relationship between safety climate and occupational fatigue in nurses. METHOD: This descriptive-analytical study was performed on nurses working in hospitals affiliated to Zabol University of Medical Sciences in 2019. 143 nurses were selected by the proportional sampling method and entered the study. Demographic questionnaires, Occupational Fatigue Inventory (SOFI), and Nurses' Safety Assessment Questionnaire were used for data collection. Statistical tests, including Independent T-Test, ANOVA, Mann-Whitney U, Kruskal-Wallis, and multivariate analysis of variance (MANOVA) were used to analyze the results using SPSS software version 21, and the multivariate structural equation was used for modeling. RESULTS: The mean scores of safety climate and occupational fatigue were 67.15±12.73 and 85.09±41.49, respectively. Job and demographic variables except for the second job (P-value = 0.065) had a significant effect on the variables of safety climate and occupational fatigue. There were also higher scores for occupational fatigue and all of its subscales in the group of women compared to the group of men. CONCLUSION: The results showed that occupational and demographic variables have significant effects on safety climate and occupational fatigue. There was a significant relationship between demographic variables of age, work experience, and education level with safety climate. There was also a significant relationship between education level, job satisfaction, satisfaction with colleagues and work experience with occupational fatigue. Therefore, paying attention to fatigue and safety climate of nurses in workplaces is recommended.

The effects of neck, core, and combined stabilization practices on pain, disability, and improvement of the neck range of motion in elderly with chronic non-specific neck pain.

BACKGROUND: Chronic non-specific neck pain is the most prevalent neck pain with notable impacts on the quality of life in the elderly. OBJECTIVE: The impacts of the neck, core, and combined stabilization practices on pain, disability, and improvement of the neck range of motion in the elderly with chronic non-specific neck pain were examined. METHOD: A quasi-experimental (open label) study was carried out through a cluster sampling in two phases in Tehran-Iran in 2017. Totally, 102 patients were randomly allocated to three groups of specific neck stabilization, specific core stabilization, and combined practices through envelope method. The intervention took 12 weeks. To measure the severity of pain and neck disability, the visual analog scale (VAS), neck disability index (NDI), and neck pain and disability scale (NPDS) was used. A goniometer was used to measure the range of the motion. To examine data, used SPSS (v.20). RESULT: The results, confirmed a significant decrease in pain over the time in the three therapeutic groups (p = 0.000). In addition, there was a significant difference between neck, core, and combined stabilization groups. Moreover, there was a significant increase in the angle of motion in all treatment groups with different treatment duration (P = 0.000). The highest increase in the angle of motion was after 12 weeks of practice in right lateral flexion (RLF) (p = 0.000). CONCLUSION: Twelve sessions of the neck, core, and combined stabilization practices can alleviate the pain and improve the strength in the elderly with chronic non-specific neck pain. In addition, compared to two other methods, the combined method was a more efficient way to improve the range of motion in patients.

Risk Perception in the COVID-19 pandemic; a health promotion approach.

BACKGROUND: Many measures have been taken so far to minimize the outbreak of COVID-19, but it is still unclear to what extent people have understood the risk. Public participation plays a vital role in better and effective control of the coronavirus, and the importance of risk perception is effective in their preventive behavior. The aim of this study was to investigate the pandemic risk perception of coronavirus disease after began of pandemic in Iranian society. MATERIALS AND METHODS: This cross-sectional study was conducted in Iran in spring 2020. The data collection tool was a researcher-made questionnaire. The questions were extracted through interviews with experts and summarizing the opinions of public interviews, etc., The questionnaire was made available to the public through social media. The information was collected within 3 months. Quantitative data were reported as mean ± standard deviation and the qualitative data were reported as number and percent. Multiple linear regression and cross were also used to examine the demographic factors associated with risk perception. Data Analysis was performed using the SPSS version 21 statistical software. RESULTS: In this study, 402 individuals from 28 provinces (Azarbaijan Gharbi, Azarbaijan Sharghi, Alborz, Ardabil, Bushehr, Chaharmahal and Bakhtiari, Esfahan, Fars, Ghazvin, Gilan, Golestan, Hamedan, Hormozgan, Ilam, Kerman, Kermanshah, Khorasan Razavi, Khorasan Shomali, Khuzestan, Kohgiluyeh and Boyerahmad, Kurdistan, Lorestan, Mazandaran, Semnan, Sistan and Baluchestan, Tehran, Yazd, and Zanjan) of Iran participated. The risk perception score obtained from the sum of the scores of the questions was classified into quartiles. Accordingly, the risk perception score of (22.9) 92 people was very low, (26.6) 107 people low, (26.9) 108 people moderate, and (23.6) 95 people high. The results of multiple linear regression showed that the variables of gender (P = 0.008) and occupation (P = 0.013) had a significant relationship with risk perception. There was no significant relationship between risk perception and variables of age, marital status, and level of education (P > 0.05). CONCLUSION: The study showed that the risk perception of the people is more in categories of moderate to high. Assessing the risk perception of a pandemic can be helpful for preventive measurements and planning, and also, according to the results of the research, can be done appropriate educational interventions. Given that 47.5% of respondents were employees, of course, it should be noted that in sending a questionnaire virtually, there is usually a lot of loss and this is a limitation of the research. The results of this study can be useful in making prevention decisions and maintaining safety and health in the workplace.

Investigating the match between anthropometric measures and the classroom furniture dimensions in Iranian students with health approach: A systematic review.

Ergonomics of schools and school furniture is one of the main issues in students' education. The proportion of school furniture to the anthropometric dimensions of students is one of the main ergonomic challenges in schools that affect students' health. This systematic review study aimed to examine the match between anthropometric measures and school furniture dimensions among Iranian students. A systematic review was carried out using databases to Google Scholar, SID, IRANDOC, PubMed, MEDLINE, and ScienceDirect and specific keywords to find papers published before March 2020. The references of seminal studies were also used to extend the search scope. Totally, 11 studies entered the review. The results showed that there was no proportion between classroom furniture and students in schools under study. This lack of proportion was evident at different grades in both boys' and girls' schools. The results showed a lack of proportion between classroom furniture and Iranian students. There is a need to design and procure furniture based on the anthropometric dimensions of the society that will help to health promotion of students. An updated national anthropometric databank of Iranian students can be a step to solve the problem.

Health in disasters in Iranian schools: A systematic review.

Iran is disaster-prone country in the world. Lack of awareness and failure to have a proper response to natural disasters cause heavy damages to nations and national assets. Risk management is essential to prevent, intervene, and fight disasters as it can attenuate the destructive effects. The present study reviews studies on health in disasters in Iranian schools with an emphasis on readiness to deal with crises. The study was carried out through a systematic search using keywords in Persian and English in Iranian and international databases such as Google Scholar, SID, Magiran, Web of Sciences, PubMed, and Scopus. The time range of the search included all articles published before September 2020. The reference lists were also checked to find more articles. Totally, 575 articles were found and full-text of 32 articles were examined. After omitting repetitious items, the articles were checked by two independent researchers in terms of inclusion and exclusion criteria so that 15 articles entered the final analysis phases. The target population consisted of students, teachers, managers, and experts of disaster resilience. The articles were mostly focused on earthquake, fire, and structural safety. Implementation of health school models through improving awareness and crisis management knowledge in school officials plays a key role in improving and preserving health in school environment and safety of students. Measures like paying more attention to safety of building and physical space of schools, adding crisis management skills to curriculum as practical educations, informing parents about such risk, and educating students about safety and prevention of risks are recommended.

Quality of life in health Iranian elderly population approach in health promotion: A systematic review.

BACKGROUND: The quality of life (QOL) is essential in all different stages of life; however, It is more important for older people as it can be effective in promoting their health. Therefore, the present study aimed to review the literature on the QOL in the Iranian elderly population. MATERIALS AND METHODS: The study was carried out as a systematic review. For this purpose, all databases were searched in March 2021. The keywords used for the search were "quality of life, elderly, older adults, aging, seniors, and Iran" along with the Persian equivalents. PRISMA protocol was used to screen articles. After removing duplicate and irrelevant items, two evaluators appraised the articles separately based on a researcher-made checklist derived from the SBEM and STROBE Statement standard checklists. RESULTS: The initial search yielded 3734 studies on the QOL in the Iranian elderly population. After screening and assessing the studies based on inclusion and exclusion criteria, 22 articles remained in the study. Most of the studies (cross-sectional) were conducted in Tehran using a 36-item Short-Form Health Survey to assess the QOL. The studies investigated sociodemographic determinants, physical and health-related behaviors, and spirituality and psychological determinants of the QOL. The sociodemographic determinants were the most common factors under study. The results showed that the role of gender and socioeconomic status was the strongest among the sociodemographic characteristics. A significant association was found between the QOL in the Iranian elderly population and factors such as depression and religious confrontation. CONCLUSION: In addition to chronic diseases, diseases of the oral and dental, as well as an unhealthy diet, should be considered in the elderly. Therefore, attention should be paid to all social, physical, and psychological variables that affect the QOL of older people.

Ergonomics factors influencing school education during the COVID-19 pandemic: A literature review.

BACKGROUND: The school is one of the most critical social, educational, and training institutions and the main pillar of education in society. Education and, consequently, educational environments have the highest effect on the mentality, development, growth, welfare, concentration, performance, and learning efficiency of students. OBJECTIVES: The present study aimed to examine the effects of environmental ergonomics on the learning and cognition of pre-school students during the COVID-19 pandemic. METHODS: The study was carried out as a review article using some keywords, namely "children", "learning", "pre-school", "COVID-19", "ergonomics", and "environmental factors". Scopus, PubMed, Science Direct and Web of Science were searched to find related articles. RESULTS: Factors like color, form, and layout of classrooms, lighting and ventilation, interior decoration, and educational equipment are effective in creating interest and motivation for students to learn. CONCLUSIONS: A review of these articles showed that the presence of ergonomics in educational spaces for children increases the quality of learning and reduces stress and anxiety, and by observing health protocols, a healthy and safe environment can be provided for students.

Mental Workload and Job Satisfaction in Healthcare Workers: The Moderating Role of Job Control.

Objective: The aim of this study was to investigate the moderating role of job control in relation to mental workload and job satisfaction of healthcare workers. Methods: This cross-sectional study was carried out on 480 nurses, midwives, and administrative workers in four educational hospitals of Ardabil, Iran. Research tools were included demographic information questionnaire, NASA-TLX questionnaire, job description index (JDI) questionnaire and job control inquiry. Results: Compared with administrative workers, mental workload of nurses and midwives was significantly higher and likewise mental workload of nurses was significantly difference compared to midwives (P < 0.001). Nurses and midwives had substantially higher job satisfaction than administrative workers (P < 0.001). Also, nurses and midwives had higher job control than administrative workers (P < 0.001 and P = 0.002, respectively). Based on the designed model, the correlation between mental workload and job satisfaction was negative and significant (r = -0.22); which in the presence of job control, the relationship between the two variables of workload and job satisfaction slightly increased (r = -0.19, P < 0.001). These conditions were the same in the three job groups separately. Conclusion: Mental workload is inversely related to job satisfaction and job control. Job control plays an important role in improving working conditions in healthcare workers.

Analyses and anticipating the future trend of accidents in an electricity distribution company of Iran: A time series analysis.

BACKGROUND: Many work-related fatalities happen every year in electricity distribution companies. This study was conducted to model accidents using the time series analysis and survey descriptive factors of injuries in an electricity distribution company in Tehran, Iran. METHODS: Data related to 2010 to 2017 were collected from the database of the safety department. Time series and trend analysis were used for data analyzing and anticipating the accidents up to 2022. RESULT: Most of the accidents occurred in summer. Workers' negligence was the reason for 75% of deaths. Employment type and type of injuries had a significant relationship (p <  0.05). CONCLUSION: The anticipating model indicated occupational injuries are going to have an increase in the future. A high rate of accidents in summer maybe because of the warm weather or insufficient skills in temporary workers. Temporary workers have no chance to work in a year like permanent workers, therefore acquisition experiences may be less in them. Based on the estimating model, management should pay attention to those sectors of the company where most of the risky activities take place. Also, training programs and using personal protective equipment can help to protect workers in hazardous conditions.

Health, safety, and environmental status of Iranian school: A systematic review.

Schools are considered as a first community, which plays an essential role in developing the child's life skills; thus, it is important to provide safety and health in these places. Accordingly, health, safety, and environmental (HSE) issues in schools are among the important issues that should be considered. Therefore, the purpose of this study was to review the studies conducted on the HSE status of Iranian schools. A systematic search of databases, including Google Scholar, SID, PubMed, IRANDOC, MEDLIB, and Science Direct, was performed using keywords by March 2020. The reference lists of key studies were also scanned to find additional articles that are suitable to include in this study. Twenty-five studies met the inclusion criteria. The results of the studies showed that the surveyed schools had favorable status in terms of HSE indicators, and only 12% of the studies reported poor status. About 88% of schools had favorable or average condition. Some cases, such as lack of safe emergency exit and inadequate ergonomic seats, have been reported, and some differences have been observed in schools in rural and urban areas. The results showed that the health and safety situation in most of the urban schools in Iran is good and relatively favorable. However, there have also been some problems; hence, the implementation of integrated HSE management is imperative to improve the status of schools. Personal health education and safety education are also recommended.

A review of studies on the COVID-19 epidemic crisis disease with a preventive approach.

BACKGROUND: COVID-19 is a highly contagious acute respiratory syndrome and has been declared a pandemic in more than 209 countries worldwide. At the time of writing, no preventive vaccine has been developed and tested in the community. This study was conducted to review studies aimed at preventing the spread of the coronavirus worldwide. METHODS: This study was a review of the evidence-based literature and was conducted by searching databases, including Google Scholar, PubMed, and ScienceDirect, until April 2020. The search was performed based on keywords including "coronavirus", "COVID-19", and "prevention". The list of references in the final studies has also been re-reviewed to find articles that might not have been obtained through the search. The guidelines published by trustworthy organizations such as the World Health Organization and Center for Disease Control have been used in this study. CONCLUSION: So far, no vaccine or definitive treatment for COVID-19 has been invented, and the disease has become a pandemic. Therefore, observation of hand hygiene, disinfection of high-touch surfaces, observation of social distance, and lack of presence in public places are recommended as preventive measures. Moreover, to control the situation and to reduce the incidence of the virus, some of the measures taken by the decision-making bodies and the guidelines of the deterrent institutions to strengthen telecommuting of employees and reduce the presence of people in the community and prevent unnecessary activities, are very important.