[Benefits and limitations of using a portable ultrasound scanner (bladderscan) in pelvic radiotherapy. Narrative review of the literature]. / Bénéfices et limites de l'utilisation d'un échographe portable (bladderscan) dans le cadre des radiothérapies du pelvis. Revue narrative de littérature.

PURPOSE: The reproducibility of bladder filling influences the target volume position for pelvis radiotherapy. The objective of this study was to summarize the current knowledge on the use of portable echograph systems named Bladderscan (BS) in this context. MATERIAL AND METHODS: Review of the PubMed and Google Scholar publication databases was performed between September 2020 and April 2021. Results of this research were filtered in accordance to a set of eligibility criterias and are presented in this article. RESULTS: Keyword search yielded a total of 2407 publications, which filtered down to 10 relevant articles in accordance to the eligibility criterias. These publications described the viability of the BS measures as well as their clinical and organizational repercussions. CONCLUSION: According to multiple studies, BS allows to measure the bladder volume before each radiotherapy session. The use of BS decreases the amount of Cone Beam Computer Tomography potentially rejected due to non-conformed bladder filling, and improve the throughput of patients.

Improvement of estradiol esters monitoring in bovine hair by dansylation and liquid chromatography/tandem mass spectrometry analysis in multiple reaction monitoring and precursor ion scan modes.

RATIONALE: The control of forbidden anabolic practices in cattle in the European Union has become challenging since endogenous compounds such as estradiol derivatives can potentially be used as growth promoters. Due to the great difficulty in establishing a reference threshold value for endogenous steroids, the direct detection of steroid esters in hair is an efficient strategy for the detection of 'natural' steroid abuse in cattle. METHODS: The present study aimed to develop and validate according to the current European standards a specific liquid chromatography/tandem mass spectrometry (LC/MS/MS) analytical strategy to monitor estrogen esters in bovine hair. The analysis was performed by positive ion electrospray ionisation (ESI+) after dansylation. Two acquisition modes were then assessed: single reaction monitoring and precursor ion scanning. RESULTS: The results showed that the introduction of a dansylation step strongly improves the sensitivity of the detection of estradiol-17-esters by LC/(ESI+)-MS/MS. The CCα values are in the range 1-10 ng g(-1) after optimisation, except for estradiol decanoate for which the derivatisation is not efficient. In addition, this LC/MS/MS approach makes it possible to carry out a precursor ion scan to screen for the presence of these estradiol 17-esters in hair samples. CONCLUSIONS: Based on the specific product ions, i.e. m/z 255 in native conditions or m/z 171 after dansylation, this strategy has the advantage of detecting any (un)known estradiol ester and of giving access to the [M + H](+) ion of the suspected ester through only a single analysis.