Administration of the Mitochondrial Permeability Transition Pore Inhibitor, TRO40303, prior to Primary Percutaneous Coronary Intervention, Does Not Affect the Levels of Pro-Inflammatory Cytokines or Acute-Phase Proteins.

OBJECTIVES: In the MITOCARE study, reperfusion injury was not prevented after administration of the mitochondrial permeability transition pore (mPTP) opening inhibitor, TRO40303, in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The effects of TRO40303 on pro-inflammatory cytokines and acute-phase proteins were assessed. METHODS: STEMI patients (n = 163, mean age 62 years) with chest pain within 6 h before admission for pPCI were randomized to intravenous bolus of TRO40303 (n = 83) or placebo (n = 80) prior to reperfusion. We tested whether the groups differed in levels of IL-1ß, IL-6, IL-10, TNF, and high-sensitive C-reactive protein at various time points (0, 12, and 72 h) after PCI. Further, potential differences between groups in the change of biomarker levels between 0 and 72 h, 0 and 12 h, and 12 and 72 h were tested. RESULTS: There were no statistically significant differences between the two groups, neither in levels of pro-inflammatory cytokines nor in levels of acute-phase proteins, and there were no statistically significant differences in the change of biomarker levels between the groups considering the time intervals from 0 to 72 h, from 0 to 12 h, and from 12 to 72 h. CONCLUSION: The administration of the mPTP, TRO40303, prior to reperfusion does not alter the pharmacokinetics of pro-inflammatory cytokines or acute-phase proteins during the first 72 h after PCI.

Association of Training and Game Loads to Injury Risk in Junior Male Elite Ice Hockey Players: A Prospective Cohort Study.

Background: Training and game loads are potential risk factors of injury in junior elite ice hockey, but the association of training and game loads to injuries is unknown. Purpose: To investigate the association of chronic training and game loads to injury risk in junior male elite ice hockey players. Study Design: Cohort study; Level of evidence, 2. Methods: In this prospective cohort study, we monitored all health problems among 159 male junior ice hockey players (mean age, 16 years; range, 15-19 years) at sports-specific high schools during the 2018-2019 school year. Players reported their health problems every week using the Oslo Sports Trauma Research Center Overuse Questionnaire on Health Problems (OSTRC-H2). The number of training sessions and games was reported for 33 weeks. We calculated the previous 2-week difference in training/game loads as well as the cumulative training/game loads of the previous 2, 3, 4, and 6 weeks and explored potential associations between training/game loads and injury risk using mixed-effects logistic regression. Results: The players reported 133 acute injuries, 75 overuse injuries, and 162 illnesses in total, and an average of 8.8 (SD ±3.9) training sessions and 0.9 (SD ± 1.1) games per week. We found no association between the difference of the two previous weeks or the previous 2- 3- and 4-week cumulative, training or game load and acute injuries, nor the difference of the two previous weeks, or the previous 4- and 6-week cumulative, training or game load and overuse injuries (OR, ∼1.0; P > .05 in all models). Conclusion: In the current study of junior elite ice hockey players, there was no evidence of an association between cumulative exposure to training/game loads and injury risk.

An Examination of Training Load, Match Activities, and Health Problems in Norwegian Youth Elite Handball Players Over One Competitive Season.

Talent development is integral to the policy and organizational practice of competitive sport, but has also been associated with excessive amounts of training and competition, and athlete injuries and illnesses. The lack of available prospective data on the training and match activities of youth athletes and their health problems is therefore of concern. The aim of this study was two-fold: (a) to examine the amount and frequency of training load, match activities, injury and illness incidence, and prevalence among Norwegian youth elite handball players over the course of the 2018-2019 competitive season; and (b) to explore whether the injury rates are related to the sex or competition level of players, or their membership of the youth international team. We recruited 205 handball players (64% female, 36% male), aged 15-18 years (17.2 years ± 0.9) from five different sport school programs in southeast Norway. Data were collected daily from September 2018 to May 2019, during the competitive handball season. The variables included types of athlete activities, the number of activities, the rating of perceived exertion (RPE), and the duration of training and matches. Injury and illness data were collected weekly using the Oslo Sports Trauma Research Center (OSTRC) questionnaire. The mean number of matches per week per player was 0.9 ± 1.29; the number of weekly training events was 6.1 ± 4.4; and the mean weekly session RPE was 986 ± 1 412 arbitrary units. The players reported a total of 472 injuries, and the mean number of injuries per player was 2.3 ± 2.9. The results demonstrated a 53% weekly injury prevalence, of which 38% were categorized as substantial injuries. Male players and players who participated at the highest level of senior competition and/or the youth international team reported significantly lower weekly incidences of health problems, compared to other players. Our findings showed that players enrolled in sport school programs are exposed to high training and competition loads, and that both general and substantial health problems are common. The potential implications for talent development and future research are discussed.