RESUMO
Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1::PLAG1, RAD51B::PLAG1, and TRIM13::PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HG::PLAG1 fusion detected by RNA next-generation sequencing.
Assuntos
Proteínas de Ligação a DNA , Leiomiossarcoma , Neoplasias Retais , Humanos , Leiomiossarcoma/genética , Leiomiossarcoma/patologia , Neoplasias Retais/genética , Neoplasias Retais/patologia , Proteínas de Ligação a DNA/genética , Feminino , MicroRNAs/genética , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/genéticaRESUMO
Verrucous carcinoma (VC) is an uncommon, low-grade variant of squamous cell carcinoma. Its benign histologic appearance and indolent course may lead to a delayed diagnosis. We report a rare case of an inverted verrucous carcinoma of the buttock presenting as a slow-growing subcutaneous lesion with a draining sinus and no exophytic component, clinically mimicking abscess and gossypiboma, with magnetic resonance imaging (MRI) and pathologic correlation. Biopsy of the lesional base is mandatory for accurate diagnosis. An enhancement pattern with a convoluted undulating appearance in a subcutaneous lesion displayed on MRI should raise a consideration of inverted VC in the differential diagnosis.
Assuntos
Abscesso/patologia , Nádegas/patologia , Carcinoma Verrucoso/patologia , Corpos Estranhos/patologia , Imageamento por Ressonância Magnética/métodos , Neoplasias de Tecidos Moles/patologia , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Estatística como AssuntoRESUMO
Inflammatory bowel disease (IBD) and microscopic colitis (MC) are two distinct subgroups within the larger group of colitides. MC could manifest as collagenous colitis (CC) or lymphocytic colitis (LC). The co-occurrence of MC in patients with IBD is rare, with few cases reported. No concurrent case of MC and ulcerative colitis (UC) each presenting with distinct clinical manifestations was found in the literature review. We report a case of a 76-year-old male presenting with concurrent CC and UC. The patient's initial flare of UC was characterized by episodes of bloody diarrhea while his flare of CC was evidenced by watery diarrhea.