Detalhe da pesquisa
1.
C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes.
FASEB J
; 35(6): e21656, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34042211
2.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
ACS Chem Biol
; 19(2): 266-279, 2024 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38291964
3.
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
J Med Chem
; 67(5): 3813-3842, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422480
4.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
bioRxiv
; 2024 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405908
5.
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.
ACS Med Chem Lett
; 14(6): 833-840, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312836
6.
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
ACS Chem Biol
; 18(4): 822-836, 2023 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36944371
7.
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily.
Eur J Med Chem
; 254: 115347, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37094449
8.
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.
ACS Pharmacol Transl Sci
; 5(8): 573-602, 2022 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35983274
9.
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Front Cell Dev Biol
; 10: 886537, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35721509
10.
Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
J Med Chem
; 65(2): 1352-1369, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34807584
11.
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
J Med Chem
; 65(2): 1370-1383, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34668706
12.
Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.
STAR Protoc
; 2(4): 100822, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34568844
13.
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
J Med Chem
; 64(12): 8142-8160, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34086472