Pesquisa | BVS Violência e Saúde

1.

Glutamine-rich regions of the disordered CREB transactivation domain mediate dynamic intra- and intermolecular interactions.

Martinez-Yamout, Maria A; Nasir, Irem; Shnitkind, Sergey; Ellis, Jamie P; Berlow, Rebecca B; Kroon, Gerard; Deniz, Ashok A; Dyson, H Jane; Wright, Peter E.

Proc Natl Acad Sci U S A ; 120(47): e2313835120, 2023 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-37971402

2.

Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins.

Berlow, Rebecca B; Dyson, H Jane; Wright, Peter E.

Proc Natl Acad Sci U S A ; 119(3)2022 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-35012986

3.

Hypersensitive termination of the hypoxic response by a disordered protein switch.

Berlow, Rebecca B; Dyson, H Jane; Wright, Peter E.

Nature ; 543(7645): 447-451, 2017 03 16.

Artigo em Inglês | MEDLINE | ID: mdl-28273070

4.

An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization.

Usui-Ouchi, Ayumi; Aguilar, Edith; Murinello, Salome; Prins, Mitchell; Gantner, Marin L; Wright, Peter E; Berlow, Rebecca B; Friedlander, Martin.

Proc Natl Acad Sci U S A ; 117(45): 28297-28306, 2020 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-33106407

5.

Deletion of Tgfß signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.

Usui-Ouchi, Ayumi; Eade, Kevin; Giles, Sarah; Ideguchi, Yoichiro; Ouchi, Yasuo; Aguilar, Edith; Wei, Guoqin; Marra, Kyle V; Berlow, Rebecca B; Friedlander, Martin.

Glia ; 70(9): 1762-1776, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35611927

6.

Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein.

Berlow, Rebecca B; Martinez-Yamout, Maria A; Dyson, H Jane; Wright, Peter E.

Biochemistry ; 58(10): 1354-1362, 2019 03 12.

Artigo em Inglês | MEDLINE | ID: mdl-30775911

7.

Tight complexes from disordered proteins.

Berlow, Rebecca B; Wright, Peter E.

Nature ; 555(7694): 37-38, 2018 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-32094871

8.

Tight complexes from disordered proteins.

Berlow, Rebecca B; Wright, Peter E.

Nature ; 555(7694): 37-38, 2018 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29493600

9.

Multivalency emerges as a common feature of intrinsically disordered protein interactions.

Sipko, Emily L; Chappell, Garrett F; Berlow, Rebecca B.

Curr Opin Struct Biol ; 84: 102742, 2024 02.

Artigo em Inglês | MEDLINE | ID: mdl-38096754

10.

A Dual Regulatory Role for the Disordered C-Terminus of Protein Kinase Cα.

Berlow, Rebecca B.

Biophys J ; 114(7): 1513-1514, 2018 04 10.

Artigo em Inglês | MEDLINE | ID: mdl-29642021

11.

Redox-dependent structure and dynamics of macrophage migration inhibitory factor reveal sites of latent allostery.

Skeens, Erin; Gadzuk-Shea, Meagan; Shah, Dilip; Bhandari, Vineet; Schweppe, Devin K; Berlow, Rebecca B; Lisi, George P.

Structure ; 30(6): 840-850.e6, 2022 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-35381187

12.

The molecular basis of allostery in a facilitated dissociation process.

Appling, Francis D; Berlow, Rebecca B; Stanfield, Robyn L; Dyson, H Jane; Wright, Peter E.

Structure ; 29(12): 1327-1338.e5, 2021 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-34520739

13.

Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease.

Eade, Kevin; Gantner, Marin L; Hostyk, Joseph A; Nagasaki, Takayuki; Giles, Sarah; Fallon, Regis; Harkins-Perry, Sarah; Baldini, Michelle; Lim, Esther W; Scheppke, Lea; Dorrell, Michael I; Cai, Carolyn; Baugh, Evan H; Wolock, Charles J; Wallace, Martina; Berlow, Rebecca B; Goldstein, David B; Metallo, Christian M; Friedlander, Martin; Allikmets, Rando.

Nat Metab ; 3(3): 366-377, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33758422

14.

Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.

Wang, Yan; Berlow, Rebecca B; Loria, J Patrick.

Biochemistry ; 48(21): 4548-56, 2009 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-19348462

15.

Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation.

Berlow, Rebecca B; Dyson, H Jane; Wright, Peter E.

J Mol Biol ; 430(16): 2309-2320, 2018 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-29634920

16.

Functional advantages of dynamic protein disorder.

Berlow, Rebecca B; Dyson, H Jane; Wright, Peter E.

FEBS Lett ; 589(19 Pt A): 2433-40, 2015 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-26073260

17.

Substrate-dependent millisecond domain motions in DNA polymerase ß.

Berlow, Rebecca B; Swain, Monalisa; Dalal, Shibani; Sweasy, Joann B; Loria, J Patrick.

J Mol Biol ; 419(3-4): 171-82, 2012 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-22446382

18.

Characterization of enzyme motions by solution NMR relaxation dispersion.

Loria, J Patrick; Berlow, Rebecca B; Watt, Eric D.

Acc Chem Res ; 41(2): 214-21, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18281945

19.

Value of a hydrogen bond in triosephosphate isomerase loop motion.

Berlow, Rebecca B; Igumenova, Tatyana I; Loria, J Patrick.

Biochemistry ; 46(20): 6001-10, 2007 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-17455914

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Glutamine-rich regions of the disordered CREB transactivation domain mediate dynamic intra- and intermolecular interactions.

Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins.

Hypersensitive termination of the hypoxic response by a disordered protein switch.

An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization.

Deletion of Tgfß signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.

Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein.

Tight complexes from disordered proteins.

Tight complexes from disordered proteins.

Multivalency emerges as a common feature of intrinsically disordered protein interactions.

A Dual Regulatory Role for the Disordered C-Terminus of Protein Kinase Cα.

Redox-dependent structure and dynamics of macrophage migration inhibitory factor reveal sites of latent allostery.

The molecular basis of allostery in a facilitated dissociation process.

Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease.

Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.

Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation.

Functional advantages of dynamic protein disorder.

Substrate-dependent millisecond domain motions in DNA polymerase ß.

Characterization of enzyme motions by solution NMR relaxation dispersion.

Value of a hydrogen bond in triosephosphate isomerase loop motion.