Detalhe da pesquisa
1.
Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids.
Bioorg Med Chem
; 32: 116011, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33461145
2.
Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis.
Cytokine
; 135: 155219, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738771
3.
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Photochem Photobiol Sci
; 19(9): 1145-1151, 2020 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32821888
4.
Dietary palmitate cooperates with Src kinase to promote prostate tumor progression.
Prostate
; 79(8): 896-908, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30900312
5.
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.
Bioorg Med Chem
; 26(23-24): 6067-6075, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30448190
6.
Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.
J Lipid Res
; 58(7): 1439-1452, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28490444
7.
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Prostaglandins Other Lipid Mediat
; 130: 47-56, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28377281
8.
Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.
J Lipid Res
; 57(11): 2028-2039, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623848
9.
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.
J Biol Chem
; 290(21): 13157-67, 2015 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25839235
10.
Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.
Int J Cancer
; 139(6): 1372-8, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136745
11.
Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide.
Int J Clin Oncol
; 20(3): 438-46, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25080062
12.
Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.
BMC Cancer
; 14: 24, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24422988
13.
Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.
Photochem Photobiol Sci
; 13(11): 1621-7, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266739
14.
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bioorg Med Chem
; 22(24): 6933-44, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456083
15.
2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.
J Proteome Res
; 12(10): 4366-75, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23987666
16.
Ceramide channels: influence of molecular structure on channel formation in membranes.
Biochim Biophys Acta
; 1818(5): 1291-301, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365970
17.
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.
J Pharmacol Exp Ther
; 344(1): 167-78, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086228
18.
Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.
Biochem J
; 445(1): 81-91, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22494048
19.
Does atrioventricular reentry tachycardia (AVRT) or atrioventricular nodal reentry tachycardia (AVNRT) in children affect their cognitive and emotional development?
Pediatr Cardiol
; 34(4): 893-7, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23129107
20.
Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation.
J Biol Chem
; 286(41): 36053-36062, 2011 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21856749