Pesquisa | BVS Violência e Saúde

1.

Circadian tumor infiltration and function of CD8⁺ T cells dictate immunotherapy efficacy.

Wang, Chen; Zeng, Qun; Gül, Zeynep Melis; Wang, Sisi; Pick, Robert; Cheng, Phil; Bill, Ruben; Wu, Yan; Naulaerts, Stefan; Barnoud, Coline; Hsueh, Pei-Chun; Moller, Sofie Hedlund; Cenerenti, Mara; Sun, Mengzhu; Su, Ziyang; Jemelin, Stéphane; Petrenko, Volodymyr; Dibner, Charna; Hugues, Stéphanie; Jandus, Camilla; Li, Zhongwu; Michielin, Olivier; Ho, Ping-Chih; Garg, Abhishek D; Simonetta, Federico; Pittet, Mikaël J; Scheiermann, Christoph.

Cell ; 187(11): 2690-2702.e17, 2024 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-38723627

2.

A neutrophil response linked to tumor control in immunotherapy.

Gungabeesoon, Jeremy; Gort-Freitas, Nicolas A; Kiss, Máté; Bolli, Evangelia; Messemaker, Marius; Siwicki, Marie; Hicham, Mehdi; Bill, Ruben; Koch, Peter; Cianciaruso, Chiara; Duval, Florent; Pfirschke, Christina; Mazzola, Michael; Peters, Solange; Homicsko, Krisztian; Garris, Christopher; Weissleder, Ralph; Klein, Allon M; Pittet, Mikael J.

Cell ; 186(7): 1448-1464.e20, 2023 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-37001504

3.

Dendritic cells direct circadian anti-tumour immune responses.

Wang, Chen; Barnoud, Coline; Cenerenti, Mara; Sun, Mengzhu; Caffa, Irene; Kizil, Burak; Bill, Ruben; Liu, Yuanlong; Pick, Robert; Garnier, Laure; Gkountidi, Olga A; Ince, Louise M; Holtkamp, Stephan; Fournier, Nadine; Michielin, Olivier; Speiser, Daniel E; Hugues, Stéphanie; Nencioni, Alessio; Pittet, Mikaël J; Jandus, Camilla; Scheiermann, Christoph.

Nature ; 614(7946): 136-143, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36470303

4.

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy.

Kashyap, Abhishek S; Schmittnaegel, Martina; Rigamonti, Nicolò; Pais-Ferreira, Daniela; Mueller, Philipp; Buchi, Melanie; Ooi, Chia-Huey; Kreuzaler, Matthias; Hirschmann, Petra; Guichard, Alan; Rieder, Natascha; Bill, Ruben; Herting, Frank; Kienast, Yvonne; Dirnhofer, Stefan; Klein, Christian; Hoves, Sabine; Ries, Carola H; Corse, Emily; De Palma, Michele; Zippelius, Alfred.

Proc Natl Acad Sci U S A ; 117(1): 541-551, 2020 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-31889004

5.

A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models.

Lüönd, Fabiana; Bill, Ruben; Vettiger, Andrea; Oller, Heide; Pelczar, Pawel; Christofori, Gerhard.

J Mammary Gland Biol Neoplasia ; 24(1): 39-45, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30209717

6.

[Immunotherapies - Overview, mode of action and clinical implications]. / Immuntherapie Übersicht, Wirkmechanismen, Anwendung.

Bill, Ruben; Schardt, Julian.

Ther Umsch ; 76(4): 187-194, 2019 Sep.

Artigo em Alemão | MEDLINE | ID: mdl-31498037

7.

VEGF receptor-2-specific signaling mediated by VEGF-E induces hemangioma-like lesions in normal and in malignant tissue.

Fagiani, Ernesta; Lorentz, Pascal; Bill, Ruben; Pavotbawan, Kirusigan; Kopfstein, Lucie; Christofori, Gerhard.

Angiogenesis ; 19(3): 339-58, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27038485

8.

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models.

Fagiani, Ernesta; Bill, Ruben; Pisarsky, Laura; Ivanek, Robert; Rüegg, Curzio; Christofori, Gerhard.

Angiogenesis ; 18(3): 327-45, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-26021306

9.

Favorable response to mammalian target of rapamycin inhibition in a young patient with unresectable fibrolamellar carcinoma of the liver.

Bill, Ruben; Montani, Matteo; Blum, Benedikt; Dufour, Jean-François; Escher, Robert; Bühlmann, Michael.

Hepatology ; 68(1): 384-386, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29473972

10.

Assessing PD-L1 Expression in Head and Neck Squamous Cell Carcinoma: Trials and Tribulations.

Bill, Ruben; Faquin, William C; Pai, Sara I.

Head Neck Pathol ; 17(4): 969-975, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37930471

11.

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity.

Fernandez-Rodriguez, Laura; Cianciaruso, Chiara; Bill, Ruben; Trefny, Marcel P; Klar, Richard; Kirchhammer, Nicole; Buchi, Mélanie; Festag, Julia; Michel, Sven; Kohler, Rainer H; Jones, Elham; Maaske, Andre; Vom Berg, Johannes; Kobold, Sebastian; Kashyap, Abhishek S; Jaschinski, Frank; Dixon, Karen O; Pittet, Mikael J; Zippelius, Alfred.

J Immunother Cancer ; 11(5)2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37208130

12.

CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers.

Bill, Ruben; Wirapati, Pratyaksha; Messemaker, Marius; Roh, Whijae; Zitti, Beatrice; Duval, Florent; Kiss, Máté; Park, Jong Chul; Saal, Talia M; Hoelzl, Jan; Tarussio, David; Benedetti, Fabrizio; Tissot, Stéphanie; Kandalaft, Lana; Varrone, Marco; Ciriello, Giovanni; McKee, Thomas A; Monnier, Yan; Mermod, Maxime; Blaum, Emily M; Gushterova, Irena; Gonye, Anna L K; Hacohen, Nir; Getz, Gad; Mempel, Thorsten R; Klein, Allon M; Weissleder, Ralph; Faquin, William C; Sadow, Peter M; Lin, Derrick; Pai, Sara I; Sade-Feldman, Moshe; Pittet, Mikael J.

Science ; 381(6657): 515-524, 2023 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-37535729

13.

Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.

Bill, Ruben; Deschler, Daniel G; Pittet, Mikael J; Pai, Sara I; Sadow, Peter M; Park, Jong Chul.

Cancer Rep (Hoboken) ; 5(3): e1491, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-34231337

14.

Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNÎ³-Secreting Lymphocytes and IL12-Producing Dendritic Cells.

Pfirschke, Christina; Zilionis, Rapolas; Engblom, Camilla; Messemaker, Marius; Zou, Angela E; Rickelt, Steffen; Gort-Freitas, Nicolas A; Lin, Yunkang; Bill, Ruben; Siwicki, Marie; Gungabeesoon, Jeremy; Sprachman, Melissa M; Marquard, Angela N; Rodell, Christopher B; Cuccarese, Michael F; Quintana, Jeremy; Ahmed, Maaz S; Kohler, Rainer H; Savova, Virginia; Weissleder, Ralph; Klein, Allon M; Pittet, Mikael J.

Cancer Immunol Res ; 10(1): 40-55, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34795032

15.

Tumor-infiltrating dendritic cell states are conserved across solid human cancers.

Gerhard, Genevieve M; Bill, Ruben; Messemaker, Marius; Klein, Allon M; Pittet, Mikael J.

J Exp Med ; 218(1)2021 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-33601412

16.

Distinct contributions of partial and full EMT to breast cancer malignancy.

Lüönd, Fabiana; Sugiyama, Nami; Bill, Ruben; Bornes, Laura; Hager, Carolina; Tang, Fengyuan; Santacroce, Natascha; Beisel, Christian; Ivanek, Robert; Bürglin, Thomas; Tiede, Stefanie; van Rheenen, Jacco; Christofori, Gerhard.

Dev Cell ; 56(23): 3203-3221.e11, 2021 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-34847378

17.

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.

Siwicki, Marie; Gort-Freitas, Nicolas A; Messemaker, Marius; Bill, Ruben; Gungabeesoon, Jeremy; Engblom, Camilla; Zilionis, Rapolas; Garris, Christopher; Gerhard, Genevieve M; Kohl, Anna; Lin, Yunkang; Zou, Angela E; Cianciaruso, Chiara; Bolli, Evangelia; Pfirschke, Christina; Lin, Yi-Jang; Piot, Cecile; Mindur, John E; Talele, Nilesh; Kohler, Rainer H; Iwamoto, Yoshiko; Mino-Kenudson, Mari; Pai, Sara I; deVito, Claudio; Koessler, Thibaud; Merkler, Doron; Coukos, Alexander; Wicky, Alexandre; Fraga, Montserrat; Sempoux, Christine; Jain, Rakesh K; Dietrich, Pierre-Yves; Michielin, Olivier; Weissleder, Ralph; Klein, Allon M; Pittet, Mikael J.

Sci Immunol ; 6(61)2021 07 02.

Artigo em Inglês | MEDLINE | ID: mdl-34215680

18.

The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer.

Tiede, Stefanie; Meyer-Schaller, Nathalie; Kalathur, Ravi Kiran Reddy; Ivanek, Robert; Fagiani, Ernesta; Schmassmann, Philip; Stillhard, Patrick; Häfliger, Simon; Kraut, Norbert; Schweifer, Norbert; Waizenegger, Irene C; Bill, Ruben; Christofori, Gerhard.

Oncogenesis ; 7(9): 73, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30237500

19.

Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism.

Wiedmer, Tabea; Blank, Annika; Pantasis, Sophia; Normand, Lea; Bill, Ruben; Krebs, Philippe; Tschan, Mario P; Marinoni, Ilaria; Perren, Aurel.

Mol Cancer Ther ; 16(11): 2502-2515, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-28729403

20.

The Rip1Tag2 Transgenic Mouse Model.

Bill, Ruben; Christofori, Gerhard.

Methods Mol Biol ; 1464: 151-161, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27858364

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