Detalhe da pesquisa
1.
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
Mol Cell
; 69(5): 729-743.e7, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29499131
2.
Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.
Proc Natl Acad Sci U S A
; 119(42): e2209044119, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36227917
3.
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Mol Cell
; 57(5): 873-886, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25684204
4.
Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer.
Nat Chem Biol
; 16(11): 1218-1226, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32807965
5.
Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc Natl Acad Sci U S A
; 115(5): E886-E895, 2018 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339518
6.
Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices.
Nat Chem Biol
; 12(10): 845-52, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27547919
7.
BH3-triggered structural reorganization drives the activation of proapoptotic BAX.
Mol Cell
; 40(3): 481-92, 2010 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21070973
8.
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Proc Natl Acad Sci U S A
; 112(6): 1761-6, 2015 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25624485
9.
Direct activation of full-length proapoptotic BAK.
Proc Natl Acad Sci U S A
; 110(11): E986-95, 2013 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23404709
10.
Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.
Anal Chem
; 87(19): 9855-63, 2015 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26308379
11.
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
Nat Chem Biol
; 9(10): 643-50, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23974116
12.
BAX activation is initiated at a novel interaction site.
Nature
; 455(7216): 1076-81, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18948948
13.
A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential.
Nat Commun
; 15(1): 274, 2024 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177138
14.
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
Proc Natl Acad Sci U S A
; 107(32): 14093-8, 2010 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660316
15.
Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.
Nat Commun
; 13(1): 3669, 2022 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35760926
16.
Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation".
ACS Chem Biol
; 17(4): 804-809, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35319882
17.
Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange.
J Am Soc Mass Spectrom
; 32(3): 753-761, 2021 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33534566
18.
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.
Cell Rep
; 37(8): 110037, 2021 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34818536
19.
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
J Cell Biol
; 220(1)2021 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33284322
20.
A redox switch regulates the structure and function of anti-apoptotic BFL-1.
Nat Struct Mol Biol
; 27(9): 781-789, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661419