Detalhe da pesquisa
1.
5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.
Bioorg Med Chem
; 56: 116632, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35078032
2.
Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
Biochemistry
; 60(8): 607-620, 2021 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33586948
3.
Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Biochemistry
; 60(48): 3714-3727, 2021 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34788017
4.
Synthesis of phosphonate derivatives of 2'-deoxy-2'-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides.
Tetrahedron
; 89: 132159, 2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33879930
5.
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew Chem Int Ed Engl
; 60(18): 10172-10178, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33616279
6.
Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866875
7.
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg Med Chem Lett
; 27(8): 1840-1847, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28274633
8.
Corrigendum to "5'-Phosphonate modified oligoadenylates as potent activators of human RNase L" [Bioorg. Med. Chem. 56 (2022) 116632].
Bioorg Med Chem
; 58: 116654, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153131
9.
Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.
Antimicrob Agents Chemother
; 60(1): 316-22, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503655
10.
Purine analogs as phosphatidylinositol 4-kinase IIIß inhibitors.
Bioorg Med Chem Lett
; 26(11): 2706-12, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27090557
11.
Discovery of ß-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
Bioorg Med Chem Lett
; 25(12): 2484-7, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978965
12.
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.
Kidney Int
; 86(2): 350-7, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646860
13.
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
Antimicrob Agents Chemother
; 58(3): 1546-55, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366736
14.
Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.
Antimicrob Agents Chemother
; 58(4): 1943-51, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24419340
15.
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Antimicrob Agents Chemother
; 58(4): 1930-42, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24419349
16.
Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction.
Org Lett
; 26(4): 819-823, 2024 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38236576
17.
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure
; 32(4): 433-439.e4, 2024 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325369
18.
Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.
Antimicrob Agents Chemother
; 57(10): 4982-9, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23896476
19.
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
ACS Infect Dis
; 9(1): 23-32, 2023 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36472628
20.
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Eur J Med Chem
; 259: 115685, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37567057