Detalhe da pesquisa
1.
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Nat Chem Biol
; 14(3): 311-316, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29377001
2.
Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.
Nature
; 485(7399): 465-70, 2012 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22622570
3.
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Nature
; 476(7360): 341-5, 2011 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21685886
4.
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.
Proc Natl Acad Sci U S A
; 111(11): 3955-60, 2014 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24516150
5.
RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.
J Hepatol
; 64(4): 899-907, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658687
6.
Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice.
Gut
; 64(9): 1444-53, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25416068
7.
Treatment of erythropoietin deficiency in mice with systemically administered siRNA.
Blood
; 120(9): 1916-22, 2012 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22611156
8.
Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.
Angew Chem Int Ed Engl
; 53(52): 14397-401, 2014 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25354018
9.
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors.
Proc Natl Acad Sci U S A
; 107(34): 15199-204, 2010 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20699217
10.
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Proc Natl Acad Sci U S A
; 105(38): 14533-8, 2008 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18779591
11.
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.
Mol Ther Methods Clin Dev
; 18: 62-72, 2020 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32577433
12.
In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.
Mol Ther Nucleic Acids
; 19: 252-266, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855834
13.
Liquid-crystal organization of liver tissue.
Elife
; 82019 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31204997
14.
JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?
World J Gastroenterol
; 13(48): 6478-91, 2007 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18161917
15.
Identification of cell cycle-targeting microRNAs through genome-wide screens.
Cell Cycle
; 16(23): 2241-2248, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29099267
16.
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.
Nat Biotechnol
; 35(12): 1179-1187, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29131148
17.
Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.
Dev Cell
; 42(6): 616-625.e8, 2017 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28890072
18.
Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.
Cancer Cell
; 31(4): 576-590.e8, 2017 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28399412
19.
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.
Nat Biotechnol
; 34(3): 328-33, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26829318
20.
Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis.
Mol Cell Endocrinol
; 401: 173-88, 2015 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25524456