[The value of serum tissue polypeptide specific antigen TPS concentration in therapeutic monitoring of patients with epithelial malignant ovarian neoplasms]. / Wartosc oznaczania stezenia specyficznego polipeptydowego antygenu TPS w surowicy w monitorowaniu leczenia chorych na nablonkowe zlosliwe nowotwory jajnika.

DESIGN: The aim of this study was compare the concentrations TPS and CA 125 in serum 37 patients with ovarian carcinoma in order to evaluate the usefulness of markers in monitoring therapy. MATERIAL AND METHODS: The concentrations of TPS and CA 125 were determined prior to surgery, 1 week after surgery, prior chemotherapy, after 3 and 6 course chemotherapy next every 3 months for the first year and every 6 month for the next 2 years. RESULTS: The concentration of TPS decreased above cutoff values in all patients with remission after 3 course chemotherapy, CA 125 after 6 course chemotherapy. In patients with remission the increase of TPS preceded 3 to 12 months, of CA 125 1 to 3 month the reoccurence of the disease. In of patients with progressive disease the TPS levels decreased during therapy and next rise. CONCLUSIONS: The current observations demonstrate that serial measurements of TPS appear to be useful for the evaluation of therapy and monitoring of patients.

[Seasonal changes in donor's sperm motility: CASA parameters]. / Wyniki komputerowej oceny seminologicznej w grupie dawców nasienia--zmiany sezonowe parametrów CASA.

Computer assisted semen analysis was employed to find out whether there are some changes in movement parameters between autumn-winter and spring-summer time. 473 sperm specimens obtained from 12 sperm donors were analyzed. Statistically significant percentage of motile spermatozoa was higher during spring-summer time.

Significance of some tumor markers in differential diagnosis of ovarian tumor.

The levels of CA-125, CA 72-4 and CEA were evaluated in serum of patients with various histological types and clinical stages of ovarian carcinoma and of benign ovarian tumor. An increased CA-125 was found in 8% patients with benign ovarian tumor. The antigens CA 72-4 and CEA exhibit values below the cut-off limit. CA-125 value was significantly elevated in patients with serous and CA 72-4 with ovarian mucinous carcinoma. An increase of CA-125 was found in 81% of patients with serous, 60% with endometrioid and 30% with ovarian mucinous carcinoma. An increase of CA 72-4 was found in 76% of patients with mucinous, 54% with serous and 45% with ovarian endometrioid carcinoma. Insignificant rise of CEA value was found in 8% of patients with serous, 10% with endometrioid and 15% with ovarian mucinous carcinoma. The frequency of increased concentration of antigens level showed a trend to significant increase and a correlation with the clinical stage of disease. The observations allow to conclude that the determination of CA 72-4 in the serum may be useful in differentiation diagnostics of benign and malignant ovarian tumors. The combined determination of CA-125 and CA 72-4 is useful in differentiation of histological types of ovarian tumors and their clinical stage.