[Comparison of spectrophotometric and colorimetric methods in determination of clavulanic acid]. / Porównawcze oznaczanie kwasu klawulanowego metoda hydroksyloaminowa i spektrofotometryczna.

The spectrophotometric method for determination of clavulanic acid and amoxycillin after NaOH hydrolysis was elaborated.

[Determination of moxalactam, aztreonam and imipenem by the perchloric hydroxylamine method]. / Oznaczanie moksalaktamu, aztreonamu i imipenemu metoda hydroksyloaminowo-nadchloranowa.

The reaction of perchloric hydroxylamine was adopted for determination of new beta-lactam antibiotics within monobactam, carbapenem and oxazepam groups. Complexes formed in colour reaction are stable over 2 hours in the case of aztreonam and imipenem, and over 1 hour for moxalactam, statistical analysis proved that both hydroxylamine-perchloric and spectrophotometric methods can be used alternatively.

Spectrophotometric and chromatographic determinations of kanamycin A in pharmaceutical preparations.

Acid hydrolysis of kanamycin A gives 5-aminomethylfurfural which can be determined quantitatively colorimetricaly by the colour complex with orcinol and FeCl3. This method gives results which correlate with the results of microbiological assay. Kanamycin B, tobramycin kasugamycin did not produce this colour reaction.