The effort-doors task: Examining the temporal dynamics of effort-based reward processing using ERPs.

Aberrant reward processing is a cardinal feature of various forms of psychopathology. However, recent research indicates that aberrant reward processing may manifest at temporally distinct substages and involve interdependent subcomponents of reward processing. To improve our understanding of both the temporal dynamics and distinct subcomponents of reward processing, we added an effort manipulation to the "doors" reward-task paradigm, to derive behavioral and event-related potential (ERP) measures of effort-based reward processing. Behavioral measures consisting of reaction time, response rate, and response rate change were used to index effort expenditure, and ERP measures were used to index attention allocated toward effort-completion cues, anticipation of reward, valuation of reward, and attention toward monetary feedback. Reduced response rate and slowing of response were evident during the high effort versus the low effort condition. ERP findings indicated increased attention to signals of high- compared to low-effort completion cues-as well as reduced anticipation of rewards, and reduced attention toward feedback information following high effort expenditure. Participants showing the most response-rate slowing evidenced the greatest reward devaluation following high versus low effort. Findings demonstrate that the addition of an effort expenditure manipulation to the doors reward paradigm produced reliable ERP and behavioral measures of effort-based reward processing, providing opportunities for future researchers to utilize the effort-doors task to parse the temporal dynamics of both anticipatory and consummatory reward processing components.

Effort and Appetitive Responding in Depression: Examining Deficits in Motivational and Consummatory Stages of Reward Processing Using the Effort-Doors Task.

Background: Reward sensitivity is a dimensional construct central to understanding the nature of depression. Psychophysiological research on this construct has primarily focused on the reward positivity, an event-related potential (ERP) that indexes consummatory reward sensitivity. This study extended prior research by focusing on ERPs that index the motivational component of reward. Methods: A novel effort-for-reward task was used to elicit motivational and consummatory ERPs. Groups consisting of 34 participants with depression and 32 participants without depression were compared across a range of reward-related ERPs. Results: Participants with depression exhibited reduced responsivity to effort completion cues following high effort expenditure, reduced anticipation of rewards after low effort expenditure (i.e., the stimulus preceding negativity), and reduced reward positivity following high effort expenditure. ERPs occurring prior to reward receipt accounted for unique variance in depression status and differentiated between subgroups of depressed individuals. Conclusions: Findings support the utility of leveraging multiple ERPs that index separate reward processing deficits to better characterize depression and depressive subtypes.

Boldness moderates cognitive performance under acute threat: Evidence from a task-switching paradigm involving cueing for shock.

Understanding factors that influence behavioral performance in high-pressure contexts is relevant to critical occupations such as first responders, military personnel, and frontline medical workers. A recent study by Yancey et al. (2019) demonstrated an association between boldness, a biobehavioral trait reflecting social dominance and fearlessness, and enhanced task-switching performance during threat of shock relative to a no-shock (safe) condition. This study used a sustained threat manipulation in which cues signaling possible shock were present throughout blocks of multiple task trials. Here, we extended this work by evaluating the relationship between boldness and task-switching performance under acute threat of shock conditions, in which cues signaling possible shock occurred during individual task trials, intermingled with safe trials. Participants (N = 79) completed a task-switching procedure involving acute threat of shock in which unwarned noise probes were presented to elicit blink-startle responses. Boldness was associated with better switching performance under threat versus safe conditions, with high-bold participants who exhibited low startle potentiation during threat showing the best performance. These findings provide additional evidence that dispositional boldness is a meaningful individual difference characteristic related to effective performance in high-pressure situations and have implications for personnel selection and assignment. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A Model-Based Strategy for Interfacing Traits of the DSM-5 AMPD With Neurobiology.

The DSM-5 alternative model for personality disorders (AMPD) groups traits into domains based on factor analyses of self-report data. AMPD traits may need to be configured differently to interface with neurobiology. Focusing on biobehavioral risk for externalizing problems in 334 adults, the authors used structural modeling to evaluate how well alternative configurations of AMPD traits, operationalized using the Personality Inventory for DSM-5 (PID-5), interface with neural indicators of externalizing liability. A model specifying two correlated factors defined by traits within the PID-5 Disinhibition domain and brain-response indicators of externalizing proneness exhibited inadequate fit. However, a model using PID-5 traits with better coverage of biobehavioral externalizing liability evidenced good fit. Scores on this PID-5 trait factor, termed "PID-5 Externalizing Proneness," converged well with criterion measures of externalizing proneness and diverged from measures of threat sensitivity. Findings illustrate how AMPD traits can be configured for use in investigations of biobehavioral risk for psychopathology.

Boldness moderates the effects of external threat on performance within a task-switching paradigm.

Set shifting involves the capacity to effectively and efficiently direct mental resources in the service of dynamically changing goal representations. This capacity is important in everyday life and may be vital in situations where processing resources needed for adaptive action may be diverted by cues for external danger or threat (e.g., first responding, military combat, trauma surgery). Although considerable research has investigated performance in set-shifting tasks, little work exists on how the presence of external threats may affect the capacity to flexibly deploy cognitive resources. Even less is known about individual difference factors that might moderate such effects. The current study addressed these gaps in the literature through use of a novel task-switching procedure in which participants (N = 77) performed two tasks in alternation under shock-threat and no-shock ("safe") conditions. Results indicated that behavioral performance was impacted by the presence of threat. However, these effects were moderated by individual differences in threat reactivity as indexed by both self-report and physiological measures. Our findings serve to clarify the impact of explicit threat on set-shifting performance. In addition, they encourage further use of the threat/task-switching paradigm as a laboratory model for studying individual differences in performance under conditions of pressure or peril. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Toward a neurobehavioral trait conceptualization of depression proneness.

The etiology of major depressive disorder is heterogeneous, and differing pathways leading to the development of depression are proposed to account for alternative variants of depressive illness and their distinct comorbidity patterns. The present study was undertaken as a step toward developing a model for conceptualizing and quantifying dispositional proneness to depression, marked by reduced neural sensitivity to rewarding events and more persistent occurrence of depressive symptomatology. Using data for college and community adult participants (N = 201), we sought to quantify variations in depression proneness by combining symptom indicators of persistent depressive conditions (dysthymic disorder, depressive personality) with a brain potential response that has been shown to index sensitivity to pleasurable events-the reward positivity (RewP; Proudfit, 2015). We first extended prior work on the RewP and depression by showing that the magnitude of RewP covaried negatively with symptoms of persistent depressive conditions (dysthymia, depressive personality) but not with current levels of depression. Persistent depressive symptoms and the RewP were then combined to form a composite neuroclinical index of depression proneness. Compared to persistent depressive symptoms alone, this composite dimensional index showed improved specificity of relations with diagnostic criterion measures, that is, similar-level associations with other indicators of depression proneness but significantly lower associations with fear disorder symptomatology. These findings provide evidence that a dimension of depression proneness can be quantified effectively by combining psychological indicators of persistent depression with a neurophysiological index of a core depression-related process (i.e., reward sensitivity).

Blunted Reward Sensitivity and Trait Disinhibition Interact to Predict Substance Use Problems.

Reward deficit models of addiction posit weaknesses in reward sensitivity to be promotive of substance dependence, while the externalizing spectrum model views substance problems as arising in large part from a general disinhibitory liability. The current study sought to integrate these perspectives by testing for separate and interactive associations of disinhibition and reward dysfunction with interview-assessed substance use disorders (SUDs). Community and college adults (N = 199) completed a scale measure of trait disinhibition and performed a gambling-feedback task yielding a neural index of reward sensitivity, the 'Reward Positivity' (RewP). Disinhibition and blunted RewP independently predicted SUDs, and also operated synergistically, such that participants - in particular, men - with high levels of disinhibition together with blunted RewP exhibited especially severe substance problems. Though limited by its cross-sectional design, this work provides new information about the interplay of disinhibition, reward processing, and gender in SUDs and suggests important directions for future research.