Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
Structural insight into allosteric modulation of protease-activated receptor 2.
Nature
; 545(7652): 112-115, 2017 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445455
3.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891333
4.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351971
5.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
Bioorg Med Chem Lett
; 29(20): 126611, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31447084
6.
Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound ß1-Adrenergic Receptor.
Mol Pharmacol
; 88(6): 1024-34, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385885
7.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245037
8.
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Nat Commun
; 12(1): 5475, 2021 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531380
9.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883008
10.
Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors.
J Med Chem
; 63(3): 905-927, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31577440
11.
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
J Immunother Cancer
; 8(2)2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32727810
12.
Targeting adenosine A2A receptor antagonism for treatment of cancer.
Expert Opin Drug Discov
; 13(11): 997-1003, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30336706
13.
Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals.
Sci Rep
; 8(1): 41, 2018 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311713
14.
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
SLAS Discov
; 23(5): 429-436, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316408
15.
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Nat Commun
; 12(1): 7265, 2021 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34880229
16.
Structure-based and fragment-based GPCR drug discovery.
ChemMedChem
; 9(2): 256-75, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24353016
17.
Sequenced reactions with samarium(II) iodide. Sequential intramolecular Reformatsky/nucleophilic acyl substitution reactions for the synthesis of medium-sized carbocycles.
J Org Chem
; 67(10): 3459-63, 2002 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12003559