Detalhe da pesquisa
1.
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms.
EMBO J
; 41(12): e110632, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578785
2.
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
Nucleic Acids Res
; 51(8): 3888-3902, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999602
3.
Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks.
Int J Mol Sci
; 24(15)2023 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569485
4.
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.
Genome Res
; 27(7): 1238-1249, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28385713
5.
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.
Bioorg Med Chem Lett
; 27(20): 4687-4693, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28919339
6.
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.
PLoS Genet
; 9(10): e1003832, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24098144
7.
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.
Proc Natl Acad Sci U S A
; 109(8): 2925-30, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22323612
8.
Etoposide quinone is a covalent poison of human topoisomerase IIß.
Biochemistry
; 53(19): 3229-36, 2014 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24766193
9.
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.
Chem Res Toxicol
; 26(4): 622-8, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23514406
10.
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase.
ACS Infect Dis
; 9(3): 706-715, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802491
11.
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
Blood
; 115(2): 326-30, 2010 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19884644
12.
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
J Med Chem
; 65(9): 6903-6925, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500229
13.
Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids.
ACS Cent Sci
; 7(8): 1327-1337, 2021 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34471677
14.
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
Blood
; 112(8): 3383-90, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18650449
15.
First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA.
Inorg Chem
; 49(23): 10750-2, 2010 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20973588
16.
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over ß.
J Med Chem
; 63(21): 12873-12886, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33079544
17.
Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination.
Cell Rep
; 29(2): 422-436.e5, 2019 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31597101
18.
Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA.
Cell Chem Biol
; 26(4): 502-511.e3, 2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30713098
19.
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.
PLoS One
; 5(4): e10186, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20419121