[Total hip arthroplasty after hip arthrodesis performed for septic arthritis]. / Désarthrodèse-prothèse de hanche pour séquelle d'arthrite septique: apropos d'une série de 17 cas à 6 ans de recul.

PURPOSE OF THE STUDY: Revision total hip arthroplasty (THA) after hip arthrodesis is an uncommon and challenging operation. The task would appear to be even more difficult if the arthrodesis was performed because of septic arthritis due to the theoretical risk of recurrent infection. We report our fifteen-year experience. MATERIAL AND METHODS: This retrospective study concerned 17 procedures performed in 17 patients (11 women, 6 men) between 1988 and 2003 on 5 right and 12 left hips. All of the patients had arthrodesis for sepsis: eight subsequent to tuberculosis and nine subsequent to septic arthritis (Staphylococcus aureus). We examined the impact of the initial arthrodesis (surgical technique, position, leg length) on neighboring joints and indications for de-fusion. Mean age was 53 years (range 32-74) and on average, the patients had a fixed hip for 36 years (range 7-59). Mean follow-up was six years (range 11 months to 15 years). Revision surgery was performed via a posterolateral approach for 12 hips (nine trochanterotomies) and via an anterolateral approach for five hips for implantation of nine cemented implants, six press fit implants, and two hybrid implants (cemented cup and press fit stem). Clinical assessment at last follow-up noted pain, walking capacity and joint motion. Leg length discrepancy was measured and complications were noted. RESULTS: The position of the original arthrodesis was considered satisfactory (flexion 20 degrees , adduction 0-10 degrees , external rotation 0-20 degrees ) for eight hips; leg length discrepancy was 4 cm (2-8 cm). Neighboring joints involved concerned the lumbar spine in 15 patients, the ipsilateral knee in ten patients, the contralateral knee in eight and the contralateral hip in six. The decision to remove the arthrodesis was based on functional needs related to lumbar pain (n=6), the homolateral knee (n=10, limping and leg length discrepancy), or an operation on the ipsilateral knee. After surgery, 14 hips (83%) were free of pain with improvement of the lumbar pain and pain of the homolateral knee. Six patients walked without support but 16 still had a limp. Flexion was 78 degrees . Leg length discrepancy was 2.5 cm on average and seven patients had balanced limbs. The postoperative period was uneventful for 14 of 17 patients (one paresia of the common fibular nerve, one femoral phlebitis, one early infection). Six late complications were noted: nonunion of the greater trochanter (n=2), recurrent ankylosis (n=1) and loosening (n=3). DISCUSSION AND CONCLUSION: An earlier history of infection does not appear to be a contraindication for implantation of a total hip arthroplasty after hip arthrodesis. Despite the long recovery period and the modest gain in joint motion, 80% of patients were satisfied after having had a blocked hip for 36 years on average.

[Total hip arthroplasty in patients with chronic renal failure transplant or dialysis]. / Arthroplastie totale de hanche chez l'insuffisant rénal chronique greffé ou dialysé.

PURPOSE OF THE STUDY: Total hip arthroplasty (THA) is generally proposed for renal transplant patients with invalidating hip disease. For patients on chronic dialysis, the few published series report a higher rate of complications. These patients are considered more vulnerable. We report the results of a retrospective mid-term analysis of 28 renal failure patients (37 hips) with THA comparing renal transplant recipients with chronic dialysis patients. MATERIAL AND METHODS: THA was performed on 37 hips in 28 patients with renal failure between January 1993 and 2004. Treatment for the renal disease was transplantation or chronic dialysis. Mean patient age at the time of the arthroplasty was 56 years. Nine patients had bilateral THA. At review, four patients had died and none were lost to follow-up. Mean time between transplantation and hip arthroplasty was 9.9 years. Among the fourteen dialysis patients (21 hips), five had had a renal transplant. Mean time from onset of dialysis to arthroplasty was 12.3 years. At mean postoperative follow-up of six years (range 24 months to 12 years), 24 patients were living. Thirty-five hips had no surgical history. Aseptic osteonecrosis was the dominant etiology (75% of operative indications in the graft group and 52% in the dialysis group). The preoperative Postel-Merle-d'Aubigné score was 7.6 in the dialysis group and 10.3 in the graft group. Most of the cups were not cemented (n=31, 84%), as were most of the stems (n=29, 78%). All survivors were reviewed. The PMA score was determined. RESULTS: Early postoperative complications in the dialysis patients were: deep vein thrombosis (n=3), pulmonary embolism (n=4), operative site hematoma (n=2) and immediate septic complication with prompt revision and preservation of the implants (n=1). For the graft group, complications were: early dislocation (n=2), lung disease (n=3). Four patients, all in the dialysis group, died. At review, the mean PMA score was 14.2 in the dialysis patients and 15.7 in the graft patients. There were no radiological signs of loosening, nor of polyethylene wear, and no ectopic ossifications could be identified. There were no late infections. DISCUSSION: In renal transplant recipients, total hip arthroplasty is a reliable treatment for hip disease, providing good mid-term results and a morbidity close to that observed in the general population. Conversely, dialysis patients have a greater perioperative morbidity. Use of non-cemented implants is not associated with a higher rate of loosening than with cemented implants. It can be recalled that this type of surgery must be performed within the framework of careful pluridisciplinary patient management.

[Aspergillar prosthetic hip infection with false aneurysm of the common femoral artery and cup migration into the pelvis]. / Infection aspergillaire et faux anévrisme mycotique fémoral au cours d'un descellement de prothèse totale de hanche avec migration intra-pelvienne de l'implant acétabulaire.

We report a case of Aspergillus fumigatus infection of a total hip arthroplasty. This rare infection was demonstrated at surgical revision of a loosened prosthesis with migration of the cup into the pelvis associated with a false aneurysm of the femoral artery. A vascular time was required before the orthopedic revision. This case illustrates the importance of the preoperative work-up in the event of cup migration. The double approach was required in our patient to control and repair the vascular structures. The difficult treatment of Aspergillus fumigatus is also discussed.

[Total hip arthroplasty after treatment of acetabular fracture]. / Arthroplastie de hanche pour séquelle de fracture de l'acétabulum.

PURPOSE OF THE STUDY: The aim of this retrospective analysis was to examine complications and technical difficulties observed during implantation of total hip arthroplasty (THA) after treatment of an acetabular fracture. MATERIAL AND METHODS: Forty patients (thirty men and ten women), mean age 50 years, were included in the study. The acetabular fracture had been treated surgically in 23 and orthpedically in 17. Mean time from initial trauma to implantation of the THA was eleven years. Hydroxyapatite-coated cups were inserted without cement in 32 patients. Cemented cups in eight (with two Kerboull cross, one Muller ring, and five simple polyethylene). Five femoral stems were cemented. Preoperative planning was designed to restore the center of the initial hip rotation to avoid excessive cup medialisation. Acetabular defects found intra-operatively were significantly greater in the group of patients treated orthopedically than in those treated surgically (p = 0.02). Autografts were thus used more frequently in the former (65%). RESULTS: One patient presented an intraoperative complication. The postoperative complications included phlebitis (n = 1), infection (n = 1), fibular nerve paralysis (n = 2), dislocation (n = 4), and heterotopic ossification (n = 7). The rate of postoperative complications was significantly higher in the group of patients treated surgically (52.2% versus 17.6%, p < 0.02). At last follow-up, mean 52 months, the mean Postel-Merle-d'Aubigne function score was 16.7. The rate of acetabular revision was 15% with four cemented cups being replaced at more than ten years due to aseptic loosening. Two press-fit cups were replaced early for infection in one patient and disassembly in another. DISCUSSION: Despite the high rate of complications, the mid-term results were good, encouraging us to continue this procedure as the first intention treatment using either a press fit cup with or without an autograft, or a cemented cup with a metal ring (Kerboull or Burch-Schneider).

[Desmoplastic fibroma or bone desmoid tumor: two cases]. / Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.

Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958. It accounts for 0.1 to 0.3% of all benign bone tumors. To date, about 150 cases involving the locomotor system have been reported. Histology is required for certain diagnosis of desmoplastic fibroma. The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma. We report two new cases of desmoplastic fibroma of the locomotor system. The observations illustrate the radiological diagnosis. MRI was used to search for local extension in bone or soft tissues. Biopsy is necessary to confirm the diagnosis. The histological presentation may be difficult to recognized and distinguish from low grade fibrosarcoma. After treatment, the rate of local recurrence is high in the event of partial resection. Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.

Serotonin-stimulated phospholipase A2 and collagenase activation in chondrocytes from human osteoarthritic articular cartilage.

We have previously described several receptors on the chondrocyte membrane. In an attempt to further characterize the coupling mechanisms of serotoninergic receptors, here we examined the involvement of serotonin in the phospholipase A2 activity. Serotonin dose-dependently stimulated phospholipase A2. This activation enhanced collagenase type II activity and had no effect on proteoglycanase activity.

Relationship between rearfoot and forefoot orientation and ground reaction forces during running.

In this study, footprint and ground reaction forces (GRF) were simultaneously recorded from 32 male subjects running barefoot. Angle between the rearfoot and the forefoot in static (alpha S) and in running (alpha R) conditions, and orientation of both, rearfoot (alpha rf) and forefoot (alpha ff) with the direction of running (DOR), were measured and correlated to selected GRF parameters. The dynamic rearfoot/forefoot angle (alpha R) was correlated, positively with arch deformation (r = 0.58, P < 0.001), vertical Fz loading peak (r = 0.60, P < 0.001), mediolateral, and anteroposterior force rates (r = 0.47 and 0.48, P < 0.01), and negatively with stance time (r = -0.41, P < 0.05) and total course of the force application point path (r = -0.71, P < 0.001). Both a medial and a lateral rotation were observed on footprint between the rearfoot and the forefoot in the horizontal plane. A medially rotated forefoot ("closed foot") was associated to a rigid and inverted foot, whereas a laterally rotated forefoot ("open foot") was associated to a flexible and everted foot.

Synovial lipoma arborescens of the hip.

Lipoma arborescens is a rare intra-articular tumor usually found in the knee joint. The reported lesion involved the inferomedial recess of the right hip synovium, in a 29-year-old male. The clinical findings were nonspecific. Both arthrography and computerized tomography (CT) of the hip disclosed the tumor which, on CT examination, showed an inhomogeneous low density, due to its fat content. The final diagnosis was given by histological examination of the resected mass. No recurrence was observed after one year. The long-term prognosis probably depends more on the underlying disorder of the joint than on the lipoma itself.

[Developments in the treatment of osteosarcoma since 1979. Report of the statistics at the Centre Léon-Bérard]. / [Evolution du traitement de l'ostéosarcome depuis 1979. A propos de la statistique du Centre Léon-Bérard.

Seventy-two patients with a localized osteosarcoma were treated between September 1979 and December 1987 by neoadjuvant chemotherapy, local surgery and post-operative chemotherapy. Chemotherapy regimens varied throughout the years but always comprised high dose methotrexate with leucovorin rescue and adriamycin pre-operatively for children under the age of 15, and ifosfamid and cis platinum in adults. Post-operative chemotherapy for bad responders (greater than 10% of residual malignant cells), was at first an association of adriamycin and cis platinum, and later of holoxan and cis platinum. Surgery changed from amputation to local conservative surgery (graft or prosthesis) which is now the most frequent surgery--61% of the patients are alive and disease-free at 5 years. Good responders to pre-operative chemotherapy have a much better prognosis (81% at 5 years) than bad responders (45%). There is no significant difference according to age or pre-operative chemotherapy regimen.

Modeling the moving skeleton of walking subjects.

The proposed study consists in moving several bones such as pelvis, femur and tibia in conditions as similar as possible to those obtained in a walking subject, to evidence the functioning of this hip and knee joints. The analysis is performed during the stance phase when the joints are loaded. This study is the first phase of a research consisting in: (i) the visualization of the motion of joints in both normal and pathologic subjects; and (ii) the calculation in real time of articular loading caused by muscular forces when sustaining both the external and inertial loads. This research will provide the kinematic and dynamic boundary conditions applied to both a knee and a hip prosthesis of the patient in movement.

[Perforation of the cervical esophagus and hypopharynx complicating surgery by an anterior approach to the cervical spine]. / Les perforations de l'oesophage cervical et de l'hypopharynx compliquant la chirurgie par voie antérieure du rachis cervical.

Difficult diagnostic and therapeutic problems are raised by perforations of the cervical oesophagus or hypopharynx in patients undergoing surgery to the cervical spine via an anterior approach. Based on their experience of three recent cases, the authors review the diagnostic approach, based on clinical examination and diatrizoate sodium oesophageal series, and propose conservative treatment consisting of surgical drainage with or without suture of the perforation and without removal of the osteosynthesis material, appropriate antibiotic therapy and hypercaloric enteral nutrition via nasogastric tube. The prevention of this complication is based on correct use of surgical retractors.

[Total hip arthroplasty. Risk factors and prevention of iatrogenic vascular complications]. / Arthroplasties totales de hanche. Facteurs de risque et prévention descomplications vasculaires iatrogènes.

Vascular injuries during orthopaedic hip surgery are rare. However, they must always be feared because they threaten life and limb. We present 11 vascular injuries observed over a 12-year period. Seven women and 4 men, treated by elective surgery, presented 14 vascular injuries (6 arterial, 5 venous and 3 prosthetic vascular graft). Four injuries occurred during revision procedures. They were all operated as an emergency for ischaemic syndrome (6 cases) and/or haemorrhage (7 cases). Four patients (37%) died and 4 developed sequelae, various directly attributable to the vascular injury. In the light of these cases, we tried to determine the various mechanisms of the injury and the orthopedic and vascular risk factors. Preoperative detection and well defined therapeutic rules are very important for the prevention of these severe vascular accidents.

[Total hip prosthesis in coxarthrosis following congenital hip dislocation (65 hips reviewed at 5 years)]. / Prothèses totales de hanche dans la coxarthrose sur luxation congénitale (65 hanches revues à 5 ans).

In 45 patients, 65 hips with CDH were given a THR after 5 years or more, with an average follow up of 8.5 years. The results and the technical problems are discussed. Of those 65 hips, there were 46 anterior dislocations, 15 intermediate dislocations and 4 cases of posterior dislocation. The mean shortening was 58.3 mm. In all cases, the authors performed a total arthroplasty on the original acetabulum, after lowering and reconstruction of the acetabulum by grafts taken from the femoral head. There are some immediate postoperative complications: 12 thromboembolic complications, hematomas and 2 cases of paralysis of the peroneal nerve. There was loosening in 8 patients (12%), with 3 infections. The functional results were good in 85% and poor in 7.5%. Nevertheless, the limp was maintained in 49 patients. There was residual low back pain in 7 patients. In 14% a second operation on the homolateral knee was performed after an average time of 2 years. The technical problems are discussed: the cup should be placed in the original acetabulum and in evaluating the lowering of the acetabulum, the condition of the lumbar spine should be considered. Posterior luxation is discussed as well; the authors recommend prudence in the indication for THR operations with lowering of the acetabulum shell.

[Extra-abdominal desmoid tumors. Therapeutic indications. Apropos of 28 cases]. / Tumeurs desmoïdes extra-abdominales. Indications thérapeutiques. A propos de 28 cas.

Between 1965 and 1989, 46 desmoid tumors were observed in the hospitals of Lyon. Twenty-eight patients with an extra-abdominal tumor, with a follow-up of at least 6 months were observed. In this group, there were 12 males and 16 females with an average of 26.7 years. Surgical treatment was performed in 26 cases (in one case no treatment was given and in another case isolated chemotherapy was given). In 21 cases (80%) a recurrence of the tumor was seen after the first excision, incomplete in 6 cases. The highest rate of recurrence was seen in the neck, the girdles and the lower limbs; at the end of our review, 9 patients still had a tumor. No primary amputation were performed but two late amputations, one of which was major, were necessary. One tumor evolved into a sarcoma and in another case, lung metastases were seen. Associated radiotherapy was given in 9 cases with resolution in 55%. Tamoxifen was used in 5 cases with stabilization of the tumor. The risk of recurrence was higher in males (p = 0.0147). Age less than 30 years, and incomplete removal of the tumor were the other predictive factors for recurrence (the difference was not significant).

[Arthrodesis of the ankle under arthroscopy. Apropos of 10 cases reviewed after a year]. / L'arthrodèse de cheville sous arthroscopie. A propos de 10 cas revus à plus de 1 an.

PURPOSE OF THE STUDY: The technique, results and indications for arthroscopic ankle fusion are detailed and compared with open technics. MATERIAL AND METHODS: 10 arthroscopic ankle fusions were performed between 1991 and 1993. This procedure was used in 4 cases of rheumatoid arthritis, 5 cases of osteoarthritis and 1 case of joint destruction consecutive to hemophilia. All patients were followed until fusion with an average follow-up of 12 months. The quality and position of the fusion were analyzed clinically and on radiograms. RESULTS: 9 patients obtained fusion in a neutral position and were able to walk with normal shoes. The average time to fusion was 14.5 weeks (8 to 40). 1 case failed and required reoperation after 15 months. No local complications were observed. DISCUSSION: Arthroscopic ankle fusion is a safe procedure with good results in cases with relatively little deformities. Its main interest lies in the low rate of complications. The technique does not increase the rate of fusion when compared to open technics. CONCLUSION: Arthroscopic fusion is recommended in cases with little to moderate deformities in the presence of poor wound healing factors.

[Associated homolateral fractures of the neck and shaft of the femur]. / Fractures associées homolatérales du col et de la diaphyse fémorale

The authors have reviewed 25 cases of associated fractures of neck and shaft of the same femur. Some were treated conservatively, others were operated on. They conclude that the best treatment should be surgical on both foci. They recommend nailing of the shaft, the nail being introduced in the anterior aspect of the greater trochanter, and screwing of the neck, the screws being located behind the nail. In cases of low diaphyseal fractures plating was used. However a high rate of non-unions was noted in such cases.

[Total hip prosthesis after high femoral osteotomy]. / Prothèses totales de hanche après ostéotomie fémorale haute.

This study reviews a series of 75 total hip prosthesis (THP) after high femoral osteotomy operated on between 1968 and 1986. The mean delay between osteotomy and THP was 14 years. 53 prosthesis were available for long term follow-up with a mean follow up of 7 years. It was included in the category of total hip prosthesis operations considered as difficult. The lateral view is indispensable to plan the operation. Valgus intertrochanteric osteotomies and moderate internal translations posed no problems. Trochanteric osteotomy did not have to be systematic; it's inconveniences were not neglectible. It was reserved for isolated varizations for it modifies the axis of entry of the stem. The reamer was used in cases of narrowing of the femoral canal; notably after significant medializations. Derotation osteotomy was the last resort when it was impossible to position the stem secondary to a subtrochanteric osteotomy or significant angulation in the sagittal plane. An intertrochanteric osteotomy, when correctly realised, posed few problems during placement of a total hip prosthesis and licits a continued use in young subjects. Results of THP after intertrochanteric osteotomy compared well with primary THP, with 77.5 per cent good results and 15 per cent loosening. In addition to problems posed by etiologies (congenital dislocations), subtrochanteric osteotomies rendered cementing extremely difficult, even impossible. At long term, only 14.5 per cent of the results were good and the loosening rate was 45 per cent. Fortunately subtrochanteric osteotomies are practically abandoned.

[Recent fractures of the humeral diaphysis. Apropos of a continuous series of 200 cases, of which 107 were treated with a hanging cast alone. (Arterial intra-osseous vascularization of the humerus)]. / Fractures récentes de la diaphyse humérale. A propos d'une série continue de 200 observations dont 107 traitées uniquement par le plâtre pendant (Etude de la vascularisation artérielle intra-osseuse de l'humérus)

Were reviewed 200 fractures of humeral diaphysis, two cases have been excluded because they were incomplete; 175 patients out of 200 have been reexamined a long time after; 23 have not been reexamined but held a sufficient follow up. Most of the transversal fracture were met among young adults (56 per 100 traffic accidents). The intraosseous vascularisation was studied elucidating partly the greatest frequency of pseudarthrosis in the part 1/3 middle-1/3 inferior especially after exaggerated periostal elevation. Among 107 cases treated by hanging cast were noted 4 pseudarthrosis, 12 shoulder's stiffnesses. Traction or external fixation were rarely useful (comminuted fractures, burns). Surgical procedures were rarely necessary because this type of fracture usually united with good result after conservative treatment. The outcomes of 40 osteosynthesis were examined and non-unions were noted. Vascular (4 out of 200) and nervous (29 out of 200) complications were also noted.

[Surgical treatment of acetabular fractures: outcome in a series of 60 consecutive cases]. / Traitement chirurgical des fractures de l'acétabulum: résultats d'une série continue de 60 cas.

PURPOSE OF THE STUDY: The aim of this study was to analyze clinical and radiographic results after surgical treatment of acetabular fractures. MATERIAL AND METHODS: We reviewed 60 consecutive fractures of the acetabulum with loss of joint congruency at mean 5-years follow-up after treatment. There were 49 men and 11 women, mean age 41 years. According to the R.O. grading, the fractures were: 22 class A (33.3%) including 17 type A1, 23 class B (38%) including 10 type B1a2, 14 class C (23.3%) and 1 unclassifiable. Eight of the patients had associated pelvic injury, 40 had hip dislocations and 9 had sciatic nerve injury. Ten femoral head fractures were discovered during the surgical procedure. Three surgical approaches were used: 1) Kocher Langenbeck approach (28 cases), 2) Mears and Rubash triradiate approach (8 cases), 3) extended iliofemoral approach (22 cases), 4) other approaches (2 cases). Anteroposterior and 45 degrees oblique view of the pelvis were obtained for all patients following admission. Computerized tomography scans were performed in all cases. Fracture displacement and congruency of the femoral head with the roof were documented according to the SOFCOT radiographic criteria. The quality of reduction was assessed using the Matta criteria and the Duquennoy and Senegas criteria. Clinical outcome was assessed at follow-up using the Postel-Merle-d'Aubigné score. RESULTS: Anatomic reduction was achieved in 62% of the cases (1 mm or less displacement on all views) and congruency of the femoral head with the roof was excellent in 73% of the cases. Clinical outcome was satisfactory in 80% (excellent or good). Operative complications included significant ectopic bone in 21, and in 2 others sciatic nerve palsy that had resolved at 1 year follow-up. Three patients developed avascular necrosis of the femoral head. DISCUSSION: Clinical outcome depends on the quality of the reduction. Class C and class B fractures with roof injury should thus be treated by large surgical exposure. The triradiate approach increases the incidence of ectopic bone. The higher incidence of ectopic bone in patients treated by osteotomy of the trochanter compared with patients without osteotomy of the trochanter was significant (p<0.05). Avascular necrosis of the femoral head was associated with delayed reduction (66% of the cases). CONCLUSION: Our good clinical results are encouraging; we are pursuing the use of surgical treatment for displaced acetabular fractures. Clinical outcome depends on the use of the appropriate surgical approach.

[Combination of methylmethacrylate (acrylic cement) and antibiotics. Bacteriologic and mechanical study]. / Association méthacrylate de méthyle (ciment acrylique) et antibiotiques. Etude bactériologique et mécanique.

The authors report the results of a study about the association of acrylic cement with antibiotics. Three cements have been tested: Simplex, CMW, Palacos, with 14 different antibiotics. A series of experiments has been carried out in three phases: a macroscopic study of the polymerisation of the mixture; in vitro bacteriological studies; and mechanical studies (trials of resistance to traction, flexion, shock measuring the modulus of elasticity and hardness). In vivo bacteriological testings have been carried out on 10 patients. It has come out from this study that the polymerisation of cement, usually does not destroy antibiotics which remain active and that the mechanical properties of cement are modified in sundry manners. All additions of tested antibiotics modifie mechanical properties by about 25 p. 100 but some additions seem to be preferable. Improvements must still be made and confirmed by this type of research.