Detalhe da pesquisa
1.
Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm.
Lab Invest
; 103(6): 100127, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889541
2.
Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease.
Neurobiol Dis
; 174: 105862, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36113749
3.
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
EMBO Rep
; 21(10): e50197, 2020 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32761777
4.
Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain.
Alzheimers Dement
; 2022 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920592
5.
Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.
Brain
; 143(6): 1905-1919, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32504082
6.
An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
J Biol Chem
; 292(37): 15277-15286, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760828
7.
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model.
Hum Mol Genet
; 24(21): 6198-212, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26276810
8.
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
EMBO Rep
; 16(9): 1114-30, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162776
9.
A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration.
Acta Neuropathol
; 130(1): 145-57, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25917047
10.
Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.
Acta Neuropathol
; 130(4): 559-73, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350237
11.
Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.
Acta Neuropathol
; 128(4): 505-24, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25173361
12.
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
J Neurochem
; 126(6): 781-91, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23742080
13.
Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion.
Acta Neuropathol
; 125(2): 289-302, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23053135
14.
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS.
Acta Neuropathol
; 126(6): 829-44, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24129584
15.
Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies.
Acta Neuropathol Commun
; 11(1): 109, 2023 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37415197
16.
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Cell Rep
; 42(8): 112822, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37471224
17.
Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models.
Biomedicines
; 11(10)2023 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37893236
18.
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Acta Neuropathol
; 123(6): 807-23, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539017
19.
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Proc Natl Acad Sci U S A
; 106(18): 7607-12, 2009 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19383787
20.
Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model.
Front Cell Dev Biol
; 10: 863089, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35386195