Successful birth after intrafallopian transfer of microhatched embryos.

OBJECTIVE: To present a successful transfer of microhatched embryos to the fallopian tubes via microlaparoscopy. DESIGN: Case report. SETTING: Private practice affiliated with a medical university. PATIENT: A 40-year-old woman with primary infertility, mildly elevated baseline FSH levels, and a history of poor ovarian response to ovulation induction. Her husband had severe oligoospermia after vasectomy reversal. INTERVENTION(S): Late luteal leuprolide acetate to pituitary down-regulation followed by pure FSH, 300 IU, and hMG, 300 IU, daily for ovulation induction. Transvaginal oocyte retrieval, intracytoplasmic sperm injection, assisted embryo hatching, microlaparoscopic intrafallopian ET. MAIN OUTCOME MEASURE(S): Amniocentesis at the 14th week of gestation revealed a normal karyotype (46,XX), birth of a normal female infant (3700 g). RESULT(S): Establishment of a single, viable intrauterine gestation followed by a vaginal delivery at term. CONCLUSION(S): This case shows the possibility of using assisted-hatched embryos for laparoscopic intrafallopian tube transfer.

Heart murmur in pediatrics: innocent or pathologic?

In a sample of 256 children referred to the São Paulo Hospital for consultation because of heart murmurs the incidence of innocent murmur was 41%. A clinical history and physical examination was performed in every child. The diagnosis was confirmed without the use of laboratory tests in only 5.5% of the cases: 32% of the children were submitted to chest x-ray and electrocardiogram; an echocardiogram had to be performed in 61% of the children and in 1.1% the catheterism was necessary to make the diagnosis. In the great majority of children with high suspicion of innocent murmur a good history and physical examination will suffice to confirm the diagnosis. If heart disease is suspected, laboratory tests should be performed for further evaluation. Any physician should be able to distinguish between pathologic and innocent murmurs based on their clinic features. The authors present a short review about the subject.