Health care policy. U.S. priorities-HIV prevention.

One of the scientific anomalies of the AIDS epidemic is the large difference in infection rates across populations. Given limited resources and segregated epidemics, prevention funding should be directed to population segments with high HIV prevalence and incidence. However, recent surveys of U.S. populations indicate that the allocation of prevention dollars is not consistent with the distribution of HIV in the population.

Prevalence of AIDS-related risk factors and condom use in the United States.

A national probability survey of human immunodeficiency virus (HIV)-related risk factors among the general heterosexual population, the National AIDS (acquired immunodeficiency syndrome) Behavioral Surveys, has obtained data from 10,630 respondents. Data are presented on the prevalence of HIV-related risks in the general heterosexual population, on the distribution of the three largest risk groups across social strata, and on the prevalence and distribution of condom use among heterosexuals reporting a risk factor. Between 15 and 31 percent of heterosexuals nationally and 20 and 41 percent in cities with a high prevalence of AIDS reported an HIV risk factor. Condom use was relatively low. Only 17 percent of those with multiple sexual partners, 12.6 percent of those with risky sexual partners, and 10.8 percent of untested transfusion recipients used condoms all the time. Overall, the results suggest that current HIV prevention programs have, to a very limited extent, reached those heterosexuals with multiple sexual partners but have failed to reach many other groups of the heterosexual population at risk for HIV. New public health strategies may be needed for these specific risk groups.

Bridging barriers to clinic-based HIV testing with new technology: translating self-implemented testing for African American youth.

Numerous barriers to clinic-based HIV testing exist (e.g., stigmatization) for African American youth. These barriers may be addressed by new technology, specifically HIV self-implemented testing (SIT). We conducted a series of formative phase 3 translation studies (49 face-to-face interviews, 9 focus groups, 1 advisory panel review) among low-income African American youth (15-19 years) and providers of adolescent services in two US cities to identify potential translation difficulties of the OraQuick SIT. Based on content analysis, we found that providers and African American youth viewed SITs positively compared to clinic-based testing. Data suggest that SITs may reduce social stigma and privacy concerns and increase convenience and normalization of HIV testing. Challenges with SIT implementation include difficulties accessing confirmatory testing, coping with adverse outcomes, and instructional materials that may be inappropriate for low socioeconomic status (SES) persons. Study results underscore the need for translation studies to identify specific comprehension and implementation problems African American youth may have with oral SITs.

Coping with death anxiety: help-seeking and social support among gay men with various HIV diagnoses.

UNLABELLED: OBJECTIVE, DESIGN AND PARTICIPANTS: We examined sources of help-seeking related to worries or concerns about death and dying and the effects of social support on death anxiety in a longitudinal sample of gay men (n = 52). RESULTS: Friends and primary sexual partners were the most frequent sources sought in dealing with death concerns for all groups of respondents (HIV-negative, HIV-positive asymptomatic, and HIV-positive symptomatic). Men experiencing HIV symptoms were more likely than HIV-negative and asymptomatic men to use formal sources of support (medical, psychological). Although HIV-positive symptomatic men did not differ from HIV-negative men in terms of help-seeking from family sources, they were significantly more likely to seek the help of family members than HIV-positive asymptomatic men. All three HIV groups showed significantly different mean levels of death anxiety, with HIV-negative men reporting the lowest level and HIV-positive symptomatic men the highest. Among HIV-negative men, only mental health sources of support (psychologists and clergy) were significantly related to death anxiety, measured 1 year later (beta = -0.35). These sources of support were also associated with death anxiety among HIV-positive asymptomatic men, but in the opposite direction (beta = 0.26). Contrary to expectations, men experiencing HIV symptoms benefited most from family support (beta = -0.31), although peer (beta = -0.19) and medical (beta = -0.28) support sources were also prominent. CONCLUSIONS: Thus, while earlier research found peers to be the most common and effective source of support among gay men, this study suggests that obtaining support from family may become particularly important as one approaches death. The effectiveness of social support in reducing death anxiety appears to vary over the course of the disease from asymptomatic to symptomatic. HIV-symptomatic men obtain support from a wide range of helpers, including medical and peer supports and family.

Behavioral factors in the spread of HIV infection.

PIP: Evidence that behavioral factors affect the spread of HIV infection, both direct and by implication from high-risk behavior in general, and a model for further research and intervention are reviewed. Measurement of prevalence of high-risk behaviors over time is essential to see whether risk is increasing or decreasing in populations. There is good evidence that AIDS education programs have controlled HIV spread among homosexual and bisexual men in San Francisco, judging by both HIV seroprevalence and that of gonococcal proctitis. These educational interventions virtually saturated the area. Other populations have failed to respond to AIDS education, particularly teens, young adults, poor, non-white, less educated, and people from other areas. 39% of AIDS cases in the U.S. are from minority groups; 50% are Black and 24% are Hispanic. Currently homosexual men living outside a gay community, those without social ties and bisexual men are still showing increasing HIV infections, while homosexual men in open, active communities have decreasing rates. Other risk-behaviors associated with HIV infection include use of drugs, alcohol, tobacco, and having sex outside of "relationships." Conditions correlated with safe behaviors included knowing of one's positive HIV status, possessing skills of safe sex, perceiving one's risk accurately, and having peer support. Peer support is extremely influential, and includes general social support, peer expectations and support for behavior change, and capability to seek help when needed. A detailed AIDS risk reduction model is proposed and described.^ieng

How many HIV infections cross the bisexual bridge? An estimate from the United States.

OBJECTIVE: Most heterosexual women with AIDS have been infected by male sex partners who acquired HIV via injecting drug use or sex with men. The contribution of bisexuality to heterosexual HIV however, has been poorly quantified. In this paper, we estimate the number of HIV infections that spread from the homosexual community to women who have sex with bisexual men. METHODS: We developed an HIV transmission model and assigned values to the model's parameters using data from a probability survey of US cities with a high risk of HIV. RESULTS: We estimated that these are about 400 HIV infections transmitted annually from HIV-infected bisexual men in high-risk cities to their female sex partners; two-thirds of these infections are transmitted to main female partners and one-third to casual partners. Uncertainties in the value of model parameters lead to variation in expected HIV infections mostly within the range 200 to 600, and for one parameter up to nearly 800. CONCLUSION: We conclude that transmission via bisexuality is a relatively minor component of the estimated 40,000 annual HIV infections in the USA.

The efficacy of brief group counseling in HIV risk reduction among homosexual Asian and Pacific Islander men.

OBJECTIVES: The incidence of AIDS is increasing at a higher rate among homosexual Asian and Pacific Islanders (API) than white homosexual men in the United States. The number of homosexual API men engaging in unsafe sex is increasing at an alarming rate. HIV risk reduction is urgently needed in this population. SUBJECTS AND METHODS: We developed and evaluated culturally appropriate brief group counseling with 329 self-identified homosexual API recruited in San Francisco between 1992 and 1994. Participants were randomized into a single, 3-h skills training group or a wait-list control group. The intervention consisted of four components: (1) development of positive self-identity and social support, (2) safer sex education, (3) eroticizing safer sex, and (4) negotiating safer sex. Data were collected at baseline and 3 months after the intervention. RESULTS: Significant reductions in number of sexual partners were observed among all treatment subjects, regardless of ethnicity (P = 0.003). Treatment decreased the number of partners reported at 3-month follow-up by 46% [95% confidence interval (CI), 28-77]. Chinese and Filipino men further benefited from the intervention: treatment subjects from these two ethnic groups reduced unprotected anal intercourse at follow-up by more than half when compared to their counterparts (odds ratio = 0.41; 95% CI, 0.19-0.89; P = 0.024). CONCLUSIONS: We demonstrated the efficacy of brief group counseling in reducing HIV risk among homosexual API. Cities with significant API populations should adopt culturally tailored skills training as part of HIV prevention strategies for this group of homosexual men.

Many people who seek anonymous HIV-antibody testing would avoid it under other circumstances.

Decreases in high-risk behavior have been observed when people have sought anonymous or confidential HIV-antibody testing accompanied by counseling. HIV-antibody testing also benefits those who are tested, since people who find that they are seropositive can receive closer medical follow-up, and, in certain cases, medical treatment. However, debates continue about appropriate testing policy. This study concerns the conditions under which people who are currently seeking anonymous testing at an alternative test site would be willing to obtain testing. On self-administered questionnaires all sexual orientation/gender groups expressed reluctance to obtain testing if anonymity were not assured. Bisexual men were especially concerned about seeking testing if there was mandatory reporting. Believing that one was infected with HIV was slightly associated with a decreased inclination to obtain testing under non-anonymous circumstances.

Hormonal changes and sexual function in aging men.

A cross-sectional study on 220 men, aged 41-93 yr, was conducted to determine whether age-related changes in circulating pituitary and gonadal hormone levels are related to quantitatively assessed changes in sexuality over this age span. The conclusion of most previous studies, that total and free plasma testosterone (T) levels decline with advancing age as gonadotropins increase, was corroborated. These changes were found to roughly parallel a decline in sexual function affecting the level of sexual activity, libido, and potency measures. PRL and estradiol did not change with age, and the age-related decline in free T was greater than that in total T. Decreases in free T and increases in LH manifested significant, but small, correlations with sexual hypofunction. Behavioral variables were also clearly related to LH and to the ratio of free T to LH and estradiol. The data also suggested that aging and hormonal changes were more strongly related to sexual activity and nocturnal erections that to libido (enjoyment, drive, and thoughts). Partial correlation procedures demonstrated that diseases and drugs were not responsible for the hormone-behavior relationships. Declining androgen levels, reduced sexual activity, and decreased sexual interest thus appear to be related sequelae of the aging process in men. Hormonal factors do not completely account for age-related changes in sexuality, although the full explanation of these changes must include a consideration of hormonal factors.

Methodological problems in AIDS behavioral research: influences on measurement error and participation bias in studies of sexual behavior.

An unprecedented number of human sexuality studies have been initiated in response to the acquired immune deficiency syndrome (AIDS) epidemic. Unfortunately, methodological developments in the field of sex research have been slow in meeting the demands of AIDS investigations focusing on the diverse populations at risk for infection with the human immunodeficiency virus (e.g., adolescents, gay men, intravenous-drug users, ethnic minorities, elderly transfusees). In this article, we review and integrate current literature on measurement error and participation bias in sex research, with an emphasis on collecting sexual information in the context of AIDS. The relevance of these findings for AIDS-related sex research is discussed, and recommendations are made to guide future investigations.

Predictors of follow-through on plans to be tested for HIV.

INTRODUCTION: Fewer than 40% of people in the United States with HIV risk factors have been tested. However, almost 40% of untested individuals with HIV risk factors in high AIDS prevalence cities stated in the 1991 National AIDS Behavioral Surveys (NABS) that they (1) "planned to be tested" or (2) "would get tested if no one could find out." METHODS: We used longitudinal data from the 1991 and 1992 NABS (n = 5,543), which are nationally representative telephone surveys. We assessed whether untested individuals were tested one year later, and we used logistic regressions to address two research questions: What are the predictors of testing among untested individuals? What are the predictors of testing among untested individuals who "planned to be tested" or "would get tested if no one could find out?" RESULTS: We found that 30% of individuals who "planned to be tested," 16% of individuals who "would get tested if no one could find out," and 11% of persons with no intentions to be tested had been tested one year later (P < .001). In regression analyses, risk factors and higher education were key predictors of testing. CONCLUSIONS: It is encouraging that 30% of individuals who plan to be tested did get tested within one year. Further research, however, needs to examine testing barriers for the 70% of individuals who do not follow through on testing plans. The results provide important information for targeting testing programs, developing effective public policies, and addressing the debate over issues such as name reporting and the availability of home HIV tests.

Who plans to be tested for HIV or would get tested if no one could find out the results?

We analyzed the characteristics of individuals at risk for HIV who have not been tested but who (1) planned to be tested, or (2) would get tested "if no one other than you (the respondent) could find out your results." Data were from the 1991 National AIDS Behavioral Surveys, a probability sample of the U.S. population. Logistic regression was used to analyze the correlates of testing behavior among the 41% of individuals in high-prevalence cities who had HIV risk factors (n = 3,175). Of this group, 7% planned to be tested and 30% would get tested "if no one other than you could find out the results." Minorities and individuals with less education and without insurance were more likely to plan to be tested (versus previously tested), and individuals with less education and lower incomes were more likely to be willing to be tested "if no one other than you could find out the results" (versus previously tested). We conclude that a variety of options to increase testing rates should be explored, including accessible testing services, policies and procedures to increase perceptions of testing privacy, and home testing.

Relationship of sexual mixing across age and ethnic groups to herpes simplex virus-2 among unmarried heterosexual adults with multiple sexual partners.

Sexual mixing is important to understanding how sexually transmitted diseases (STDs) spread in the general population, and, identifying people who mix across social groups aids HIV-STD prevention. The authors examined (a) the extent to which people have sexual partners from other sexual networks (disassortative mixing) in a probability sample of unmarried heterosexual adults reporting multiple sexual partners (N = 545) and (b) the relationship between mixing and Herpes Simplex Virus-2 (HSV-2). After demographic variables and number of lifetime sexual partners were controlled for, heavy mixers were significantly more likely to be HSV-2 positive. Degree of mixing down produced the most powerful relationship to HSV-2. Age, education, ethnicity, and a history of incarceration or IV drug use were found to distinguish between light and heavy mixers, although differences between ethnic and age mixing were observed. The results have implications for understanding HIV-STD transmission and for directing interventions toward population segments at high risk for transmitting HIV-STDs.

A test of the AIDS risk reduction model: psychosocial correlates of condom use in the AMEN cohort survey.

We examined the AIDS Risk Reduction Model (J. Catania, S. Kegeles, & T. Coates) in a sample of unmarried heterosexual adults with an HIV risk factor (n = 716). Labeling one's sexual behavior as risky was associated with having a history of sexually transmitted diseases, particularly genital herpes, and fewer stereotypic health beliefs. For people with secondary sexual partners, greater condom commitment was related to increased labeling, supportive condom norms, and greater enjoyment, and high levels of condom use were related to greater condom commitment, supportive norms, greater enjoyment, and health protective sexual communication. For people with primary partners, greater condom commitment was correlated with increased supportive condom norms, greater enjoyment, and having genital herpes, and high levels of condom use were correlated with greater condom commitment, greater enjoyment, and health protective sexual communication.

Multiple sexual partners and their psychosocial correlates: the population-based AIDS in multiethnic neighborhoods (AMEN) study.

In this study we examined multiple partners in a household probability sample of heterosexuals. Thirty-seven percent reported 2 or more partners in the past year, and 6% reported 5 or more partners. Significant interactions among gender, ethnicity, and relationship status revealed complex relations. African American men without a primary partner were the most likely to have multiple partners; ethnic minority women with primary partners were the least likely. Psychosocial factors associated with multiple partners were examined with the AIDS Risk Reduction Model (ARRM). Situational factors influenced how ARRM variables related to multiple partners. Perceived risk, commitment to monogamy, and communication were all important correlates. Prevention efforts must focus on increasing awareness of the risks of heterosexual transmission of HIV for people in dating relationships and on strengthening sexual communication skills with new partners.

Changes in condom use among homosexual men in San Francisco.

Employed data from two longitudinal surveys of gay men in San Francisco (a) to examine for cohort (Study 1) and attrition (Studies 1 and 2) bias effects on reported changes in condom use by gay men and (b) to investigate predictors of condom use (Study 2). Substantial increases in condom use were observed, and these changes were unrelated to attrition and cohort bias. In terms of predictors of condom use, men who always used condoms had higher levels of social support from informal sources of help, had more positive expectations that condoms would have positive interpersonal and personal consequences, and were more likely to be HIV positive than men who used condoms occasionally or never. The results are discussed in terms of their implications for HIV-prevention research.

PIP: 2 research studies of changes in condom use among homosexual males in San Francisco for the period 1984-88 are discussed. The 1st study examined attrition and cohort bias effects on self-reported condom use in a longitudinal cohort and multiple sample investigation. An initial baseline sample of 500 self-identified gay men was sampled and interviewed by telephone as the longitudinal cohort, with 3 cross-sectional samples later surveyed for comparison. The frequency of receptive or insertive anal intercourse with and without condoms with primary and secondary sex partners was queried for the 30-day period prior to the survey in both studies. This 1st study found a 4-fold increase in condom use over the period 1984-87 to be neither effected by repeated assessments of the longitudinal cohort, nor respondent attrition. As determinants of condom use in this population for the period 1984-88, the 2nd study examined the influence of formal and informal social support for sex behavior change, being in a mutually monogamous sexual relationships, knowing the primary partner's HIV-antibody status, knowing one's antibody status, and the expected consequences of condom use on one's self-worth, sexual pleasure, health, and perceptions of one's sex partner. Research was based on AIDS Behavioral Research Project data obtained through recruitment in bathhouses and gay bars. 529 predominantly white, while collar, college-educated men of mean age 39 years remained in the study through 1988. While condom use increased by almost 4-fold, these men have been slower to change condom use behavior than respondents in the 1st study. Informal support and knowing one's HIV status are strong predictors of condom use 1 year later. Men always using condoms were found to have more social support from informal sources, more positive expectations of condoms, positive interpersonal and personal consequences, and were more likely to be HIV-positive than occasional or non-users. Programs best suited to effect condom use changes will focus on social support, sexual pleasure, self-worth, and relationship issues. Attention should also be placed upon the erotic/pleasure dimension of using condoms, changing community norms, and factors influencing HIV-negative people to take precautions against HIV infection. Methodological limitations are discussed regarding result reliability and validity, with further research encouraged.

Alcohol use, drug use and alcohol-related problems among men who have sex with men: the Urban Men's Health Study.

AIMS: To measure the prevalence and independent associations of heavy and problematic use of alcohol and recreational drugs among a household-based sample of urban MSM (men who have sex with men). DESIGN: Cross-sectional survey. PARTICIPANTS: Men who identified as being gay or bisexual or who reported sex with another man in the prior 5 years were included in this analysis (n = 2172). SETTING: A probability telephone sample of MSM was taken within Zip Codes of four large American cities (Chicago, Los Angeles, New York and San Francisco) estimated to have total concentrations of at least 4% of all households with one resident MSM. MEASUREMENTS: Standard measures of alcohol use, problems associated with alcohol use, and recreational drug use were administered by trained telephone interviewers. FINDINGS: Both recreational drug (52%) and alcohol use (85%) were highly prevalent among urban MSM, while current levels of multiple drug use (18%), three or more alcohol-related problems (12%), frequent drug use (19%) and heavy-frequent alcohol use (8%) were not uncommon. The associations of heavy and/or problematic substance use are complex, with independent multivariate associations found at the levels of demographics, adverse early life circumstances, current mental health status, social and sexual practices and connection to gay male culture. CONCLUSIONS: The complex pattern of associations with heavy and/or problematic substance use among urban MSM suggests that heavy and/or problematic substance use is grounded in multiple levels: the individual, the interpersonal and the socio-cultural.

The prevalence of informal caregiving to persons with AIDS in the United States: caregiver characteristics and their implications.

Based on U.S. national (N = 2673) and central cities (N = 8263) probability samples, this paper: (1) presents estimates of the proportion of the United States population that has provided informal care to persons with AIDS; (2) identifies socio-demographic characteristics of 'typical' AIDS caregivers in the U.S.; and (3) discusses social, economic and health-related implications of informal caregiving to persons with AIDS. Results indicate that 5.0% of all adults age 18-75 living within central cities and 3.2% of the entire adult U.S. population have provided care to a friend, relative or lover with AIDS. Although caregivers are distributed throughout different age and ethnic groups, the majority of caregivers are younger (< 40 years) and white. Males, gay and bisexual men in particular are over-represented among central cities caregivers. Data on the types of caregiving tasks performed show that 64.4% of all caregivers within central cities perform domestic types of caregiving tasks, while 27.7% are involved in personal care of AIDS patients. Caregivers are more likely than non-caregivers to have been tested for HIV, and among the tested, caregivers are more likely to have tested positive. While informal caregiving reduces costs to the formal medical sector, costs to the caregivers themselves should be considered. Physical and emotional stress, as well as reduced opportunity for social and economic development, represent potential outcomes of caregiving. Socio-demographic characteristics of AIDS caregivers, such as their typically young age, suggest that these caregivers may be at particular risk for detrimental consequences.

Help-seeking for AIDS high-risk sexual behavior among gay and bisexual African-American men.

Help-seeking for AIDS high-risk sexual behavior and its association with HIV status were examined among 318 gay and bisexual men in the San Francisco Bay Area who participated in the African American Men's Health Project, a longitudinal survey of gay and bisexual African-American men. A third (36%) of the sample reported seeking help regarding their concerns about HIV high-risk sexual behavior. Peers and professionals were the most widely sought sources of help and the sources perceived to be the most helpful. Men (39%) who had received the HIV antibody test and who were HIV seropositive were more likely to seek help than men who were HIV seronegative or did not know their HIV status (25%). Furthermore, gay men who were HIV seropositive or who knew their serostatus were more likely to seek help from professionals and peers. Explanations for the differences in help-seeking by HIV-seropositive men are discussed with implications for the development of social support for HIV risk reduction among gay and bisexual African-American men.

Cognitive and emotional assessments of perceived risk for HIV among unmarried heterosexuals.

We examined perceived risk of contracting HIV using assessments of likelihood and worry in a probability sample of unmarried heterosexuals. Perceptions of the likelihood of contracting HIV and worry about HIV were only modestly correlated (r = .23), suggesting that they are different constructs. Far more respondents expressed worry (43%) than expressed the belief that they were at risk for HIV (9%). A significant proportion of the sample reported experiences that may have placed them at risk for HIV transmission. Demographic and psychosocial correlates of perceived likelihood and worry were examined in separate multivariate logistic analyses. Misconceptions about HIV transmission, a history of injection-drug-using sexual partners, and less education were associated with higher perceived likelihood of contracting HIV. Misconceptions, having multiple sexual partners in the past year, and a history of sexually transmitted diseases (STDs) were associated with high worry about HIV. Implications of the findings for correcting HIV-related misconceptions are discussed.