Literature mining discerns latent disease-gene relationships.

MOTIVATION: Dysregulation of a gene's function, either due to mutations or impairments in regulatory networks, often triggers pathological states in the affected tissue. Comprehensive mapping of these apparent gene-pathology relationships is an ever-daunting task, primarily due to genetic pleiotropy and lack of suitable computational approaches. With the advent of high throughput genomics platforms and community scale initiatives such as the Human Cell Landscape project, researchers have been able to create gene expression portraits of healthy tissues resolved at the level of single cells. However, a similar wealth of knowledge is currently not at our finger-tip when it comes to diseases. This is because the genetic manifestation of a disease is often quite diverse and is confounded by several clinical and demographic covariates. RESULTS: To circumvent this, we mined ∼18 million PubMed abstracts published till May 2019 and automatically selected ∼4.5 million of them that describe roles of particular genes in disease pathogenesis. Further, we fine-tuned the pretrained bidirectional encoder representations from transformers (BERT) for language modeling from the domain of natural language processing to learn vector representation of entities such as genes, diseases, tissues, cell-types, etc., in a way such that their relationship is preserved in a vector space. The repurposed BERT predicted disease-gene associations that are not cited in the training data, thereby highlighting the feasibility of in silico synthesis of hypotheses linking different biological entities such as genes and conditions. AVAILABILITY AND IMPLEMENTATION: PathoBERT pretrained model: https://github.com/Priyadarshini-Rai/Pathomap-Model. BioSentVec-based abstract classification model: https://github.com/Priyadarshini-Rai/Pathomap-Model. Pathomap R package: https://github.com/Priyadarshini-Rai/Pathomap.

Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis.

BACKGROUND: Invasive Aspergillosis (IA) is a life-threatening fungal disease with significant mortality rates. Timely diagnosis and treatment greatly enhance patient outcomes. This study aimed to explore the association between patient age and the development of IA, as well as the potential implications for risk stratification strategies. METHODS: We searched National Center for Biotechnology Information (NCBI) databases for publications until October 2023 containing age characteristics of patients with and without IA. A random-effects model with the application of inverse-variance weighting was used to pool reported estimates from each study, and meta-regression and subgroup analyses were utilized to assess sources of heterogeneity. RESULTS: A systematic review was conducted, resulting in the inclusion of 55 retrospective observational studies with a total of 13,983 patients. Meta-analysis revealed that, on average, patients with IA were approximately two and a half years older (95% Confidence Interval [CI] 1.84-3.31 years; I2 = 26.1%) than those without the disease (p < 0.0001). No significant moderators could explain the observed heterogeneity in age difference. However, subgroup analysis revealed that age differences were more pronounced within particular patient groups compared to others. For example, patients with and without IA who had primary severe lung infections exhibited a greater difference in mean age than other patient cohorts. CONCLUSIONS: Further research, such as individual patient data meta-analysis, is necessary to better understand the potential relationship between increasing age and the likelihood of IA. Improved risk stratification strategies based on patient age could potentially enhance the early detection and treatment of IA, ultimately improving patient outcomes.

Promising ferroelectric and piezoelectric response of Cr-doped ZnO nanofiller-incorporated PVDF flexible and laminated nanocomposite system.

Cr3+-doped ZnO (CZ) nanoparticles are prepared using hydrothermal and co-precipitation techniques. The desired crystallographic phase of the nanoparticles is confirmed using X-ray diffraction study. Rod-shaped and spherical morphologies of CZ nanoparticles prepared using hydrothermal and co-precipitation techniques were confirmed through FESEM observation. Each type of nanoparticle was taken separately in PVDF to understand the characteristic properties, such as dielectric, piezoelectric, and ferroelectric properties of the resultant CZ-PVDF nanocomposite films. All the nanocomposite films comprising rod-shaped or spherical CZ nanoparticles show butterfly loops with a low leakage current density of 10-5 A m-2 at a maximum electric field of 100 kV m-2 under J-E measurement. These findings suggest that the polarization property of CZ-PVDF nanocomposite films can be obtained at a high external electric field without causing electric breakdown in the samples. Dielectric permittivity as a function of temperature increases with an increase in the loading percentage of both rod-shaped or spherical CZ nanofillers in PVDF. Polarization response also improves with an increase in the loading percentage of CZ nanofillers in PVDF. In particular, the rod-shaped CZ nanofillers in PVDF with a higher loading percentage (CZHP2) result in a maximum polarization of (10 ± 0.29) × 10-4 µC cm-2, remanent polarization of (2 ± 0.04) × 10-4 µC cm-2, and coercive field of (10 ± 0.1) kV cm-1 at a maximum electric field of 50 kV cm-1. The CZHP2 nanocomposite film has a piezoelectric coefficient (d33) of (25 ± 0.24) pC N-1 and a power density of 1278.90 W m-3. These results indicate that the nanocomposite films have potential application in piezoelectric energy harvesters, offering a possible solution to the energy issue faced by modern society.

A systematic computational study of acridine derivatives through conceptual density functional theory.

A detailed computational analysis of acridine derivatives viz. acridone, 9-amino acridine hydrochloride hydrate, proflavin, acridine orange and acridine yellow is done in terms of conceptual density functional theory (CDFT). CDFT-based global descriptors-ionization potential, electron affinity, HOMO-LUMO gap, hardness, softness, electronegativity and electrophilicity index of acridine derivatives for ground state as well as excited state are estimated with the help of different hybrid functionals B3LYP/6-31G (d, p), B3LYP/6-311G (d, p), B3LYP/DGDZVP and B3LYP/LANL2DZ. Acridine derivatives show higher values of ionization potential and electron affinity in excited state as compared to ground state, indicating that these compounds are willing to accept electrons in excited state rather than donating electron. Acridone shows the maximum HOMO-LUMO energy gap in ground and excited state which implies that one-way electron transfer is most feasible with this compound. Our computed results emphasize the pronounced electron acceptor behaviour of the acridine derivatives in the excited state which has already been experimentally verified. It is observed that the trend in the computed values of the descriptors is not much improved on refinement of the basis set.

Spectrally multiplexed Hong-Ou-Mandel interference with weak coherent states.

We explore the suitability of a virtually imaged phased array as a spectral-to-spatial mode-mapper (SSMM) for applications in quantum communication such as a quantum repeater. To this end, we demonstrate spectrally resolved Hong-Ou-Mandel (HOM) interference with weak coherent states (WCSs). Spectral sidebands are generated on a common optical carrier, and WCSs are prepared in each spectral mode and sent to a beam splitter followed by two SSMMs and two single-photon detectors, allowing us to measure spectrally resolved HOM interference. We show that the so-called HOM dip can be observed in the coincidence detection pattern of matching spectral modes with visibilities as high as 45% (maximum 50% for WCSs). For unmatched modes, the visibility drops significantly, as expected. Due to the similarity between HOM interference and a linear-optics Bell-state measurement (BSM), this simple optical arrangement figures as a candidate for the implementation of a spectrally resolved BSM. Finally, we simulate the secret key generation rate using current and state-of-the-art parameters in a measurement-device-independent quantum key distribution scenario and explore the trade-off between rate and complexity of a spectrally multiplexed quantum communication link.

The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation.

Histone H3 and its variants regulate gene expression but the latter are absent in most ascomycetous fungi. Here, we report the identification of a variant histone H3, which we have designated H3VCTG because of its exclusive presence in the CTG clade of ascomycetes, including Candida albicans, a human pathogen. C. albicans grows both as single yeast cells and hyphal filaments in the planktonic mode of growth. It also forms a three-dimensional biofilm structure in the host as well as on human catheter materials under suitable conditions. H3VCTG null (hht1/hht1) cells of C. albicans are viable but produce more robust biofilms than wild-type cells in both in vitro and in vivo conditions. Indeed, a comparative transcriptome analysis of planktonic and biofilm cells reveals that the biofilm circuitry is significantly altered in H3VCTG null cells. H3VCTG binds more efficiently to the promoters of many biofilm-related genes in the planktonic cells than during biofilm growth, whereas the binding of the core canonical histone H3 on the corresponding promoters largely remains unchanged. Furthermore, biofilm defects associated with master regulators, namely, biofilm and cell wall regulator 1 (Bcr1), transposon enhancement control 1 (Tec1), and non-dityrosine 80 (Ndt80), are significantly rescued in cells lacking H3VCTG. The occupancy of the transcription factor Bcr1 at its cognate promoter binding sites was found to be enhanced in the absence of H3VCTG in the planktonic form of growth resulting in enhanced transcription of biofilm-specific genes. Further, we demonstrate that co-occurrence of valine and serine at the 31st and 32nd positions in H3VCTG, respectively, is essential for its function. Taken together, we show that even in a unicellular organism, differential gene expression patterns are modulated by the relative occupancy of the specific histone H3 type at the chromatin level.

Polarizability: a promising descriptor to study chemical-biological interactions.

Recently, we have defined atomic polarizability, a Conceptual Density Functional Theory (CDFT)-based reactivity descriptor, through an empirical method. Though the method is empirical, it is competent enough to meet the criteria of periodic descriptors and exhibit relativistic effect. Since the atomic data are very accurate, we have applied them to determine molecular polarizability. Molecular polarizability is an electronic parameter and has an impact on chemical-biological interactions. Thus, it plays a pivotal role in explaining such interactions through Structure Activity Relationships (SAR). In the present work, we have explored the application of polarizability in the real field through investigation of chemical-biological interactions in terms of molecular polarizability. A Quantitative Structure-Activity Relationship (QSAR) model is constructed to account for electronic effects owing to polarizability in ligand-substrate interactions. The study involves the prediction of various biological activities in terms of minimum block concentration, relative biological response, inhibitory growth concentration or binding affinity. Superior results are presented for the predicted and observed activities which support the accuracy of the proposed polarizability-QSAR model. Further, the results are considered from a biological viewpoint in order to understand the mechanism of interactions. The study is performed to explore the efficacy of the computational model based on newly proposed polarizability and not to establish the finest QSAR. For future studies, it is suggested that the descriptor polarizability should be contrasted with the use of other drug-like descriptors.

Cross-SEAN: A cross-stitch semi-supervised neural attention model for COVID-19 fake news detection.

As the COVID-19 pandemic sweeps across the world, it has been accompanied by a tsunami of fake news and misinformation on social media. At the time when reliable information is vital for public health and safety, COVID-19 related fake news has been spreading even faster than the facts. During times such as the COVID-19 pandemic, fake news can not only cause intellectual confusion but can also place people's lives at risk. This calls for an immediate need to contain the spread of such misinformation on social media. We introduce CTF, a large-scale COVID-19 Twitter dataset with labelled genuine and fake tweets. Additionally, we propose Cross-SEAN, a cross-stitch based semi-supervised end-to-end neural attention model which leverages the large amount of unlabelled data. Cross-SEAN partially generalises to emerging fake news as it learns from relevant external knowledge. We compare Cross-SEAN with seven state-of-the-art fake news detection methods. We observe that it achieves 0.95 F1 Score on CTF, outperforming the best baseline by 9%. We also develop Chrome-SEAN, a Cross-SEAN based chrome extension for real-time detection of fake tweets.

Divagations about the periodic table: Boolean hypercube and quantum similarity connections.

In this study, several simple aspects associated with the periodic table (PT) of the elements are commented. First, the connection of the PT with the structure of a seven-dimensional Boolean hypercube leads afterward to discuss the nature of those PT elements bearing prime atomic numbers. Second, the use of quantum similarity (QS) to obtain an alternative insight on the PT element relations will be also developed. The foundation of the second part starts admitting that any element of the PT can be attached to a schematic electronic density function, constructed with a single Gaussian function: a Gaussian atomic density function, allowing to consider the PT elements as a set of quantum objects, and permits a straightforward construction of a QS matrix. Such QS scheme can be applied to the whole PT or to any subset of it. Manipulation of the QS matrices attached to any quantum object set allows the evaluation of statistical-like values, acting as coordinates to numerically or graphically represent the chosen PT atomic element sets. © 2019 Wiley Periodicals, Inc.

Time-dependent properties of run-and-tumble particles. II. Current fluctuations.

We investigate steady-state current fluctuations in two models of hardcore run-and-tumble particles (RTPs) on a periodic one-dimensional lattice of L sites, for arbitrary tumbling rate γ=τ_{p}^{-1} and density ρ; model I consists of standard hardcore RTPs, while model II is an analytically tractable variant of model I, called a long-ranged lattice gas (LLG). We show that, in the limit of L large, the fluctuation of cumulative current Q_{i}(T,L) across the ith bond in a time interval T≫1/D grows first subdiffusively and then diffusively (linearly) with T: 〈Q_{i}^{2}〉∼T^{α} with α=1/2 for 1/D≪T≪L^{2}/D and α=1 for T≫L^{2}/D, where D(ρ,γ) is the collective- or bulk-diffusion coefficient; at small times T≪1/D, exponent α depends on the details. Remarkably, regardless of the model details, the scaled bond-current fluctuations D〈Q_{i}^{2}(T,L)〉/2χL≡W(y) as a function of scaled variable y=DT/L^{2} collapse onto a universal scaling curve W(y), where χ(ρ,γ) is the collective particle mobility. In the limit of small density and tumbling rate, ρ,γ→0, with ψ=ρ/γ fixed, there exists a scaling law: The scaled mobility γ^{a}χ(ρ,γ)/χ^{(0)}≡H(ψ) as a function of ψ collapses onto a scaling curve H(ψ), where a=1 and 2 in models I and II, respectively, and χ^{(0)} is the mobility in the limiting case of a symmetric simple exclusion process; notably, the scaling function H(ψ) is model dependent. For model II (LLG), we calculate exactly, within a truncation scheme, both the scaling functions, W(y) and H(ψ). We also calculate spatial correlation functions for the current and compare our theory with simulation results of model I; for both models, the correlation functions decay exponentially, with correlation length ξ∼τ_{p}^{1/2} diverging with persistence time τ_{p}≫1. Overall, our theory is in excellent agreement with simulations and complements the prior findings [T. Chakraborty and P. Pradhan, Phys. Rev. E 109, 024124 (2024)1539-375510.1103/PhysRevE.109.024124].

Time-dependent properties of run-and-tumble particles: Density relaxation.

We characterize collective diffusion of hardcore run-and-tumble particles (RTPs) by explicitly calculating the bulk-diffusion coefficient D(ρ,γ) for arbitrary density ρ and tumbling rate γ, in systems on a d-dimensional periodic lattice. We study two minimal models of RTPs: Model I is the standard version of hardcore RTPs introduced in [Phys. Rev. E 89, 012706 (2014)10.1103/PhysRevE.89.012706], whereas model II is a long-ranged lattice gas (LLG) with hardcore exclusion, an analytically tractable variant of model I. We calculate the bulk-diffusion coefficient analytically for model II and numerically for model I through an efficient Monte Carlo algorithm; notably, both models have qualitatively similar features. In the strong-persistence limit γ→0 (i.e., dimensionless ratio r_{0}γ/v→0), with v and r_{0} being the self-propulsion speed and particle diameter, respectively, the fascinating interplay between persistence and interaction is quantified in terms of two length scales: (i) persistence length l_{p}=v/γ and (ii) a "mean free path," being a measure of the average empty stretch or gap size in the hopping direction. We find that the bulk-diffusion coefficient varies as a power law in a wide range of density: D∝ρ^{-α}, with exponent α gradually crossing over from α=2 at high densities to α=0 at low densities. As a result, the density relaxation is governed by a nonlinear diffusion equation with anomalous spatiotemporal scaling. In the thermodynamic limit, we show that the bulk-diffusion coefficient-for ρ,γ→0 with ρ/γ fixed-has a scaling form D(ρ,γ)=D^{(0)}F(ρav/γ), where a∼r_{0}^{d-1} is particle cross section and D^{(0)} is proportional to the diffusion coefficient of noninteracting particles; the scaling function F(ψ) is calculated analytically for model II (LLG) and numerically for model I. Our arguments are independent of dimensions and microscopic details.

Artificial intelligence predicts normal summer monsoon rainfall for India in 2023.

Inaccuracy in the All Indian Summer Monsoon Rainfall (AISMR) forecast has major repercussions for India's economy and people's daily lives. Improving the accuracy of AISMR forecasts remains a challenge. An attempt is made here to address this problem by taking advantage of recent advances in machine learning techniques. The data-driven models trained with historical AISMR data, the Niño3.4 index, and categorical Indian Ocean Dipole values outperform the traditional physical models, and the best-performing model predicts that the 2023 AISMR will be roughly 790 mm, which is typical of a normal monsoon year.

Fabrication of rare earth-doped ZnO-PVDF flexible nanocomposite films for ferroelectric response and their application in piezo-responsive bending sensors.

The present study covers the fabrication of flexible piezoelectric nanogenerators and their application towards sustainable power generation. The rod-like structure of erbium-doped ZnO (EZ) nanoparticles prepared by the hydrothermal synthesis route was successfully incorporated inside the polyvinylidene fluoride (PVDF) matrix using the solution casting method. Solution casting is an easy and cost-effective method for fabricating laminated, thin, flexible and lightweight EZ-PVDF nanocomposite films. The formation of the desired crystallographic phase of EZ-PVDF nanocomposite films and the presence of rod-like EZ nanoparticles inside the PVDF matrix were confirmed using X-ray diffraction and FESEM. The enhancement of the ß-phase fraction of the EZ-PVDF nanocomposite films as compared to bare PVDF was estimated using FTIR spectroscopy. The presence of a ferroelectric phase in the EZ-PVDF nanocomposite films was found due to the formation of a large area of interfaces between the EZ nanoparticles and the PVDF matrix. The maximum polarizations of 0.00696 µC cm-2 and 0.00683 µC cm-2 for two samples (EZP1 and EZP2, respectively) were observed at an electric field of 1.25 kV cm-1. The piezoelectric voltages were observed at relatively low frequencies for both nanocomposite films. The maximum piezoelectric voltages of 18.9 V and 15.5 V were observed at a 1 Hz frequency for EZP1 and EZP2, respectively. The output piezoelectric current of 16.88 mA and the maximum power density of 7773.68 W m-3 for EZP1 ensure its potential as an efficient piezoelectric nanogenerator with greater efficiency than those reported previously in published articles. The change in the piezoelectric voltage response of the nanocomposite films as a function of mechanical movement of human external body parts renders them the most suitable candidate for human-machine interfacing (HMI) applications, such as bending sensors and human motion sensors.

Exploring the Efficacy of Large Language Models in Summarizing Mental Health Counseling Sessions: Benchmark Study.

BACKGROUND: Comprehensive session summaries enable effective continuity in mental health counseling, facilitating informed therapy planning. However, manual summarization presents a significant challenge, diverting experts' attention from the core counseling process. Leveraging advances in automatic summarization to streamline the summarization process addresses this issue because this enables mental health professionals to access concise summaries of lengthy therapy sessions, thereby increasing their efficiency. However, existing approaches often overlook the nuanced intricacies inherent in counseling interactions. OBJECTIVE: This study evaluates the effectiveness of state-of-the-art large language models (LLMs) in selectively summarizing various components of therapy sessions through aspect-based summarization, aiming to benchmark their performance. METHODS: We first created Mental Health Counseling-Component-Guided Dialogue Summaries, a benchmarking data set that consists of 191 counseling sessions with summaries focused on 3 distinct counseling components (also known as counseling aspects). Next, we assessed the capabilities of 11 state-of-the-art LLMs in addressing the task of counseling-component-guided summarization. The generated summaries were evaluated quantitatively using standard summarization metrics and verified qualitatively by mental health professionals. RESULTS: Our findings demonstrated the superior performance of task-specific LLMs such as MentalLlama, Mistral, and MentalBART evaluated using standard quantitative metrics such as Recall-Oriented Understudy for Gisting Evaluation (ROUGE)-1, ROUGE-2, ROUGE-L, and Bidirectional Encoder Representations from Transformers Score across all aspects of the counseling components. Furthermore, expert evaluation revealed that Mistral superseded both MentalLlama and MentalBART across 6 parameters: affective attitude, burden, ethicality, coherence, opportunity costs, and perceived effectiveness. However, these models exhibit a common weakness in terms of room for improvement in the opportunity costs and perceived effectiveness metrics. CONCLUSIONS: While LLMs fine-tuned specifically on mental health domain data display better performance based on automatic evaluation scores, expert assessments indicate that these models are not yet reliable for clinical application. Further refinement and validation are necessary before their implementation in practice.

A computational study of CuCrX2 (X = S, Se, Te) for intermediate band solar cell: Conceptual density functional theory approach.

Transition metals doped semiconductors have been extensively used as a greener alternative to lead-based solar cell materials. In this work, we have investigated the structure, electronic, optical, and thermo-chemical properties of CuCrX2 (X = S, Se, Te) by using the Conceptual Density Functional Theory (CDFT) approach. Different suitable exchange correlations have been used for the process of geometry optimization of systems in the study. Applied exchange correlations namely B3LYP and WB97XD demonstrate that the energy gap shows a decline from the atom S to Se to Te. HOMO-LUMO obtained from level B3LYP/LANL2DZ is in accordance with the stated data. The attained band gap directs that studied materials could be beneficial for further utilization in optoelectronic and photovoltaic devices. A comparative study has been made based on the selected exchange correlations for the analysis of investigated materials, which has not been explored commonly. The study reveals that B3LYP/LANL2DZ could be a better choice for a combination set of level and basis set for studying these types of compounds. CDFT-based global reactivity descriptors are computed and analyzed. The obtained band gap range indicates the desirable nature of CuCrX2 for further exploration in the application of Intermediate Band Solar cells.

Navigating nature's toll: Assessing the ecological impact of the refugee crisis in Cox's Bazar, Bangladesh.

The Rohingya crisis in Myanmar's Rakhine state has resulted in a significant influx of refugees into Cox's Bazar, Bangladesh. However, the ecological impact of this migration has received limited attention in research. This study aimed to address this gap by utilizing remote sensing data and machine learning techniques to model the ecological quality (EQ) of the region before and after the refugee influx. To quantify changes in land use and land cover (LULC), three supervised machine learning classification methods, namely artificial neural networks (ANN), support vector machines (SVM), and random forests (RF), were applied. The most accurate LULC maps obtained from these methods were then used to assess changes in ecosystem service valuation and function resulting from the land use changes. Furthermore, fuzzy logic models were employed to examine the EQ conditions before and after the Rohingya influx. The findings of the study indicate that the increased number of Rohingya refugees has led to a 9.58% decrease in forest area, accompanied by an 8.25% increase in settlement areas. The estimated total ecosystem services value (ESV) in the research area was $67.83 million in 2017 and $67.78 million in 2021, respectively. The ESV for forests experienced a significant decline of 21.97%, equivalent to a decrease of $5.33 million. Additionally, the reduction in forest lands has contributed to a 13.58% decline in raw materials and a 14.57% decline in biodiversity. Furthermore, utilizing a Markovian transition probability model, our analysis reveals that the EQ conditions in the area have deteriorated from "very good" or "good" to "bad" or "very bad" following the Rohingya influx. The findings of this study emphasize the importance of integrating ecological considerations into decision-making processes and developing proactive measures to mitigate the environmental impact of such large-scale migrations.

Node injection for class-specific network poisoning.

Graph Neural Networks (GNNs) are powerful in learning rich network representations that aid the performance of downstream tasks. However, recent studies showed that GNNs are vulnerable to adversarial attacks involving node injection and network perturbation. Among these, node injection attacks are more practical as they do not require manipulation in the existing network and can be performed more realistically. In this paper, we propose a novel problem statement - a class-specific poison attack on graphs in which the attacker aims to misclassify specific nodes in the target class into a different class using node injection. Additionally, nodes are injected in such a way that they camouflage as benign nodes. We propose NICKI, a novel attacking strategy that utilizes an optimization-based approach to sabotage the performance of GNN-based node classifiers. NICKI works in two phases - it first learns the node representation and then generates the features and edges of the injected nodes. Extensive experiments and ablation studies on four benchmark networks show that NICKI is consistently better than four baseline attacking strategies for misclassifying nodes in the target class. We also show that the injected nodes are properly camouflaged as benign, thus making the poisoned graph indistinguishable from its clean version w.r.t various topological properties.

Hatemongers ride on echo chambers to escalate hate speech diffusion.

Recent years have witnessed a swelling rise of hateful and abusive content over online social networks. While detection and moderation of hate speech have been the early go-to countermeasures, the solution requires a deeper exploration of the dynamics of hate generation and propagation. We analyze more than 32 million posts from over 6.8 million users across three popular online social networks to investigate the interrelations between hateful behavior, information dissemination, and polarized organization mediated by echo chambers. We find that hatemongers play a more crucial role in governing the spread of information compared to singled-out hateful content. This observation holds for both the growth of information cascades as well as the conglomeration of hateful actors. Dissection of the core-wise distribution of these networks points towards the fact that hateful users acquire a more well-connected position in the social network and often flock together to build up information cascades. We observe that this cohesion is far from mere organized behavior; instead, in these networks, hatemongers dominate the echo chambers-groups of users actively align themselves to specific ideological positions. The observed dominance of hateful users to inflate information cascades is primarily via user interactions amplified within these echo chambers. We conclude our study with a cautionary note that popularity-based recommendation of content is susceptible to be exploited by hatemongers given their potential to escalate content popularity via echo-chambered interactions.

Spatiotemporal characterization of relative humidity trends and influence of climatic factors in Bangladesh.

The frequency and intensity of climate change and resulting impacts are more prevalent in South Asian countries, particularly in Bangladesh. Relative humidity (RH) is a crucial aspect of climate, and higher RH variability has far-reaching impacts on human health, agriculture, environment, and infrastructure. While temperature and rainfall have gained much research attention, RH studies have received scant attention in the research literature. This study investigated the trends and variability of RH levels in Bangladesh and the influence of other meteorological factors over the past 40 years. Variabilities in the meteorological factors were identified by calculating descriptive statistics. Innovative trend analysis (ITA) and Mann-Kendall test (MK-test) methods were utilized to assess monthly, seasonal, and annual trends. The magnitude of temperature, rainfall, and windspeed influences on RH variability were identified using Pearson's correlation, Spearman rank correlation, and Kendall correlation model. Variability analysis showed higher spatial variations in RH levels across the country, and RH skewed negatively in all stations. Results reveal that daily, monthly, seasonal, and annual trends of RH exhibited positive trends in all stations, with an increasing rate of 0.083-0.53% per year in summer, 0.43-0.68% per year in winter, and 0.58-0.31% per year in the rainy season. Both ITA and MK-test provided consistent results, indicating no discrepancies in trend results. All three models indicate that temperature, rainfall, and windspeed have weak to moderate positive influences on changing RH levels in Bangladesh. The study will contribute to decision-making to improve crop yields, health outcomes, and infrastructure efficiency.

COVID-19 Vulnerability Mapping of Asian Countries.

OBJECTIVE: The objective of this study is to map vulnerability of Asian countries to the COVID-19 pandemic. METHOD: According to the Intergovernmental Panel on Climate Change (IPCC) 2007 framework for natural hazards, vulnerability is a function of exposure, sensitivity, and adaptive capacity. From an extensive literature review, we identified 16 socioeconomic, meteorological, environmental, and health factors that influence coronavirus disease 2019 (COVID-19) cases and deaths. The underlying factors of vulnerability were identified using principal component analysis. RESULTS: Our findings indicate that the percentage of the urban population, obesity rate, air connectivity, and the population aged 65 and over, diabetes prevalence, and PM2.5 levels all contributed significantly to COVID-19 sensitivity. Subsequently, governance effectiveness, human development index (HDI), vaccination rate, and life expectancy at birth, and gross domestic product (GDP) all had a positive effect on adaptive capacity. The estimated vulnerability was corroborated by a Pearson correlation of 0.615 between death per million population and vulnerability. CONCLUSION: This study demonstrates the application of universal indicators for assessing pandemic vulnerability for informed policy interventions such as the COVAX vaccine roll-out priority. Despite data limitations and a lack of spatiotemporal analysis, this study's methodological framework allows for ample data incorporation and replication.