Pesquisa | BVS Violência e Saúde

1.

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

Mukhamedova, Maryam; Wrapp, Daniel; Shen, Chen-Hsiang; Gilman, Morgan S A; Ruckwardt, Tracy J; Schramm, Chaim A; Ault, Larissa; Chang, Lauren; Derrien-Colemyn, Alexandrine; Lucas, Sarah A M; Ransier, Amy; Darko, Samuel; Phung, Emily; Wang, Lingshu; Zhang, Yi; Rush, Scott A; Madan, Bharat; Stewart-Jones, Guillaume B E; Costner, Pamela J; Holman, LaSonji A; Hickman, Somia P; Berkowitz, Nina M; Doria-Rose, Nicole A; Morabito, Kaitlyn M; DeKosky, Brandon J; Gaudinski, Martin R; Chen, Grace L; Crank, Michelle C; Misasi, John; Sullivan, Nancy J; Douek, Daniel C; Kwong, Peter D; Graham, Barney S; McLellan, Jason S; Mascola, John R.

Immunity ; 54(4): 769-780.e6, 2021 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-33823129

2.

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.

Andrews, Sarah F; Chambers, Michael J; Schramm, Chaim A; Plyler, Jason; Raab, Julie E; Kanekiyo, Masaru; Gillespie, Rebecca A; Ransier, Amy; Darko, Sam; Hu, Jianfei; Chen, Xuejun; Yassine, Hadi M; Boyington, Jeffrey C; Crank, Michelle C; Chen, Grace L; Coates, Emily; Mascola, John R; Douek, Daniel C; Graham, Barney S; Ledgerwood, Julie E; McDermott, Adrian B.

Immunity ; 51(2): 398-410.e5, 2019 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-31350180

3.

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults.

Wilson, Eleanor; Goswami, Jaya; Baqui, Abdullah H; Doreski, Pablo A; Perez-Marc, Gonzalo; Zaman, Khalequ; Monroy, Jorge; Duncan, Christopher J A; Ujiie, Mugen; Rämet, Mika; Pérez-Breva, Lina; Falsey, Ann R; Walsh, Edward E; Dhar, Rakesh; Wilson, Lauren; Du, Jiejun; Ghaswalla, Parinaz; Kapoor, Archana; Lan, Lan; Mehta, Shraddha; Mithani, Runa; Panozzo, Catherine A; Simorellis, Alana K; Kuter, Barbara J; Schödel, Florian; Huang, Wenmei; Reuter, Caroline; Slobod, Karen; Stoszek, Sonia K; Shaw, Christine A; Miller, Jacqueline M; Das, Rituparna; Chen, Grace L.

N Engl J Med ; 389(24): 2233-2244, 2023 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-38091530

4.

Safety, Tolerability and Immunogenicity of a mRNA-based RSV Vaccine in Healthy Young Adults in a Phase 1 Clinical Trial.

Shaw, Christine A; Mithani, Runa; Kapoor, Archana; Dhar, Rakesh; Wilson, Lauren; El Asmar, Laila; Schnyder-Ghamloush, Sabine; Schaefers, Kristi; August, Allison; Stoszek, Sonia K; Chen, Grace L.

J Infect Dis ; 2024 Jan 31.

Artigo em Inglês | MEDLINE | ID: mdl-38298125

5.

Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase I Clinical Trial in Healthy Older Adults.

Shaw, Christine A; Essink, Brandon; Harper, Charles; Mithani, Runa; Kapoor, Archana; Dhar, Rakesh; Wilson, Lauren; Guo, Ruiting; Panozzo, Catherine A; Wilson, Eleanor; Simorellis, Alana K; Reuter, Caroline; Stoszek, Sonia K; Chen, Grace L; Das, Rituparna; Goswami, Jaya.

J Infect Dis ; 2024 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-38385566

6.

A Monoclonal Antibody for Malaria Prevention.

Gaudinski, Martin R; Berkowitz, Nina M; Idris, Azza H; Coates, Emily E; Holman, LaSonji A; Mendoza, Floreliz; Gordon, Ingelise J; Plummer, Sarah H; Trofymenko, Olga; Hu, Zonghui; Campos Chagas, Andrezza; O'Connell, Sarah; Basappa, Manjula; Douek, Naomi; Narpala, Sandeep R; Barry, Christopher R; Widge, Alicia T; Hicks, Renunda; Awan, Seemal F; Wu, Richard L; Hickman, Somia; Wycuff, Diane; Stein, Judy A; Case, Christopher; Evans, Brian P; Carlton, Kevin; Gall, Jason G; Vazquez, Sandra; Flach, Britta; Chen, Grace L; Francica, Joseph R; Flynn, Barbara J; Kisalu, Neville K; Capparelli, Edmund V; McDermott, Adrian; Mascola, John R; Ledgerwood, Julie E; Seder, Robert A.

N Engl J Med ; 385(9): 803-814, 2021 08 26.

Artigo em Inglês | MEDLINE | ID: mdl-34379916

7.

The Impact of COVID-19, Mental Health Distress, and School-Based Sociocultural Protective Factors among Elementary-Aged Children and their Caregivers.

Goodwin, Aijah K B; Roberson, Anthony J; Watson, Ar'Reon; Chen, Grace L; Long, Anna C J.

Sch Psychol Int ; 44(2): 154-171, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38603375

8.

Limited Flavivirus Cross-Reactive Antibody Responses Elicited by a Zika Virus Deoxyribonucleic Acid Vaccine Candidate in Humans.

Burgomaster, Katherine E; Foreman, Bryant M; Aleshnick, Maya A; Larman, Bridget C; Gordon, David N; Maciejewski, Sonia; Morabito, Kaitlyn M; Ledgerwood, Julie E; Gaudinski, Martin R; Chen, Grace L; Mascola, John R; Debbink, Kari; Dowd, Kimberly A; Graham, Barney S; Pierson, Theodore C.

J Infect Dis ; 224(9): 1550-1555, 2021 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-33961055

9.

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study.

Gaudinski, Martin R; Coates, Emily E; Novik, Laura; Widge, Alicia; Houser, Katherine V; Burch, Eugeania; Holman, LaSonji A; Gordon, Ingelise J; Chen, Grace L; Carter, Cristina; Nason, Martha; Sitar, Sandra; Yamshchikov, Galina; Berkowitz, Nina; Andrews, Charla; Vazquez, Sandra; Laurencot, Carolyn; Misasi, John; Arnold, Frank; Carlton, Kevin; Lawlor, Heather; Gall, Jason; Bailer, Robert T; McDermott, Adrian; Capparelli, Edmund; Koup, Richard A; Mascola, John R; Graham, Barney S; Sullivan, Nancy J; Ledgerwood, Julie E.

Lancet ; 393(10174): 889-898, 2019 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-30686586

10.

Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial.

Chen, Grace L; Coates, Emily E; Plummer, Sarah H; Carter, Cristina A; Berkowitz, Nina; Conan-Cibotti, Michelle; Cox, Josephine H; Beck, Allison; O'Callahan, Mark; Andrews, Charla; Gordon, Ingelise J; Larkin, Brenda; Lampley, Rebecca; Kaltovich, Florence; Gall, Jason; Carlton, Kevin; Mendy, Jason; Haney, Doug; May, Jeanine; Bray, Amy; Bailer, Robert T; Dowd, Kimberly A; Brockett, Brittanie; Gordon, David; Koup, Richard A; Schwartz, Richard; Mascola, John R; Graham, Barney S; Pierson, Theodore C; Donastorg, Yeycy; Rosario, Nicolas; Pape, Jean William; Hoen, Bruno; Cabié, André; Diaz, Clemente; Ledgerwood, Julie E.

JAMA ; 323(14): 1369-1377, 2020 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-32286643

11.

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials.

Gaudinski, Martin R; Houser, Katherine V; Morabito, Kaitlyn M; Hu, Zonghui; Yamshchikov, Galina; Rothwell, Ro Shauna; Berkowitz, Nina; Mendoza, Floreliz; Saunders, Jamie G; Novik, Laura; Hendel, Cynthia S; Holman, LaSonji A; Gordon, Ingelise J; Cox, Josephine H; Edupuganti, Srilatha; McArthur, Monica A; Rouphael, Nadine G; Lyke, Kirsten E; Cummings, Ginny E; Sitar, Sandra; Bailer, Robert T; Foreman, Bryant M; Burgomaster, Katherine; Pelc, Rebecca S; Gordon, David N; DeMaso, Christina R; Dowd, Kimberly A; Laurencot, Carolyn; Schwartz, Richard M; Mascola, John R; Graham, Barney S; Pierson, Theodore C; Ledgerwood, Julie E; Chen, Grace L.

Lancet ; 391(10120): 552-562, 2018 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-29217376

12.

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

Gaudinski, Martin R; Coates, Emily E; Houser, Katherine V; Chen, Grace L; Yamshchikov, Galina; Saunders, Jamie G; Holman, LaSonji A; Gordon, Ingelise; Plummer, Sarah; Hendel, Cynthia S; Conan-Cibotti, Michelle; Lorenzo, Margarita Gomez; Sitar, Sandra; Carlton, Kevin; Laurencot, Carolyn; Bailer, Robert T; Narpala, Sandeep; McDermott, Adrian B; Namboodiri, Aryan M; Pandey, Janardan P; Schwartz, Richard M; Hu, Zonghui; Koup, Richard A; Capparelli, Edmund; Graham, Barney S; Mascola, John R; Ledgerwood, Julie E.

PLoS Med ; 15(1): e1002493, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-29364886

13.

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines.

Kim, Lindsay; Rha, Brian; Abramson, Jon S; Anderson, Larry J; Byington, Carrie L; Chen, Grace L; DeVincenzo, John; Edwards, Kathryn M; Englund, Janet A; Falsey, Ann R; Griffin, Marie R; Karron, Ruth A; Martin, Karen G; Meissner, H Cody; Munoz, Flor M; Pavia, Andrew T; Piedra, Pedro A; Schaffner, William; Simões, Eric A F; Singleton, Rosalyn; Talbot, H Keipp; Walsh, Edward E; Zucker, Jane R; Gerber, Susan I.

Clin Infect Dis ; 65(6): 1020-1025, 2017 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-28903503

14.

Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.

Chen, Grace L; Lamirande, Elaine W; Cheng, Xing; Torres-Velez, Fernando; Orandle, Marlene; Jin, Hong; Kemble, George; Subbarao, Kanta.

J Virol ; 88(5): 2867-76, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24371061

15.

Chikungunya Virus-Like Particle Vaccine-Reply.

Chen, Grace L.

JAMA ; 324(10): 1008-1009, 2020 09 08.

Artigo em Inglês | MEDLINE | ID: mdl-32897343

16.

Seasonal influenza infection and live vaccine prime for a response to the 2009 pandemic H1N1 vaccine.

Chen, Grace L; Lau, Yuk-Fai; Lamirande, Elaine W; McCall, Amber W; Subbarao, Kanta.

Proc Natl Acad Sci U S A ; 108(3): 1140-5, 2011 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-21199945

17.

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.

Yang, Yuhe R; Han, Julianna; Perrett, Hailee R; Richey, Sara T; Rodriguez, Alesandra J; Jackson, Abigail M; Gillespie, Rebecca A; O'Connell, Sarah; Raab, Julie E; Cominsky, Lauren Y; Chopde, Ankita; Kanekiyo, Masaru; Houser, Katherine V; Chen, Grace L; McDermott, Adrian B; Andrews, Sarah F; Ward, Andrew B.

Cell Rep ; 43(5): 114171, 2024 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-38717904

18.

Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS.

Awan, Seemal F; Pegu, Amarendra; Strom, Larisa; Carter, Cristina A; Hendel, Cynthia S; Holman, LaSonji A; Costner, Pamela J; Trofymenko, Olga; Dyer, Renunda; Gordon, Ingelise J; Rothwell, Ro Shauna S; Hickman, Somia P; Conan-Cibotti, Michelle; Doria-Rose, Nicole A; Lin, Bob C; O'Connell, Sarah; Narpala, Sandeep R; Almasri, Cassandra G; Liu, Cuiping; Ko, Sungyoul; Kwon, Young D; Namboodiri, Aryan M; Pandey, Janardan P; Arnold, Frank J; Carlton, Kevin; Gall, Jason G; Kwong, Peter D; Capparelli, Edmund V; Bailer, Robert T; McDermott, Adrian B; Chen, Grace L; Koup, Richard A; Mascola, John R; Coates, Emily E; Ledgerwood, Julie E; Gaudinski, Martin R.

JCI Insight ; 9(7)2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38587079

19.

Chikungunya virus virus-like particle vaccine is well tolerated and immunogenic in chikungunya seropositive individuals.

McCarty, James M; Bedell, Lisa; Mendy, Jason; Coates, Emily E; Chen, Grace L; Ledgerwood, Julie E; Tredo, Sarah Royalty; Warfield, Kelly L; Richardson, Jason S.

Vaccine ; 41(42): 6146-6149, 2023 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-37690874

20.

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.

Yang, Yuhe R; Han, Julianna; Perrett, Hailee R; Richey, Sara T; Jackson, Abigail M; Rodriguez, Alesandra J; Gillespie, Rebecca A; O'Connell, Sarah; Raab, Julie E; Cominsky, Lauren Y; Chopde, Ankita; Kanekiyo, Masaru; Houser, Katherine V; Chen, Grace L; McDermott, Adrian B; Andrews, Sarah F; Ward, Andrew B.

bioRxiv ; 2023 Aug 24.

Artigo em Inglês | MEDLINE | ID: mdl-37781590

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Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults.

Safety, Tolerability and Immunogenicity of a mRNA-based RSV Vaccine in Healthy Young Adults in a Phase 1 Clinical Trial.

Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase I Clinical Trial in Healthy Older Adults.

A Monoclonal Antibody for Malaria Prevention.

The Impact of COVID-19, Mental Health Distress, and School-Based Sociocultural Protective Factors among Elementary-Aged Children and their Caregivers.

Limited Flavivirus Cross-Reactive Antibody Responses Elicited by a Zika Virus Deoxyribonucleic Acid Vaccine Candidate in Humans.

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study.

Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial.

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials.

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines.

Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.

Chikungunya Virus-Like Particle Vaccine-Reply.

Seasonal influenza infection and live vaccine prime for a response to the 2009 pandemic H1N1 vaccine.

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.

Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS.

Chikungunya virus virus-like particle vaccine is well tolerated and immunogenic in chikungunya seropositive individuals.

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.