Prooxidant modifications in the cryptome of beef jerky, the deleterious post-digestion composition of processed meat snacks.

Snacking has traditionally been associated with consumption of foods rich in fats and carbohydrates. However, new dietary trends switched to consumption of protein-rich foods. This study investigates the impact of food processing on the cryptome of one of the most widely consumed meat snacks, beef jerky. We have performed discovery-driven proteome-wide analyses, which identified a significantly elevated presence of reactive prooxidant post-translational modifications in jerky. We also found that these protein decorations impact an important subset of in-silico predicted DNA binding cryptides. Furthermore, we observed cell-dependent reduction in cell viability after prolonged treatments with endogenous-like jerky digests. Collectively these findings uncover the presence of prooxidant modifications in processed dried beef snacks and associate their presence with cytotoxicity. Thus, the findings reported here can pave the way for future studies aimed to establish appropriate dietary recommendations on snacking trends.

Low-temperature fabrication of Au-Co cluster mixed nanohybrids with high magnetic moment of Co.

In recent years, the synergistic effects of Au-based hybrids have generated enormous scientific interest. The hybrids of Au and Co are expected to exhibit attractive properties. In this paper, we report the successful fabrication of the nanohybrids between bulk-immiscible Au and Co with chain-like structures via a mild solution method. Elemental mapping, XRD and EXAFS data reveal that the as-prepared AuCo nanohybrids might be of cluster mixed configuration. A sequential redox and imperfection-promoted aggregation/diffusion process is proposed to elucidate the formation mechanism of the nanohybrids. The as-prepared products exhibit a temperature-independent saturation magnetization with the magnetic moment of Co as high as ~2.95 µ(B) for each Co atom at 300 K, much higher than the bulk value (~1.7 µ(B) for each Co atom) and approaching the theoretical value of an atomic Co (~3.0 µ(B) for each Co atom).