Evaluation of the impact of weak end feedback on the SBS threshold in high-power narrow-linewidth fiber amplifiers.

In this work, we quantitatively investigate the SBS threshold in high-power narrow-linewidth fiber amplifiers seeded with phase-modulated single-frequency lasers in presence of weak end feedback. The impacts of the end feedback and spectral linewidths on the SBS threshold are demonstrated in detail through comparative experiments and numerical simulations, respectively. In the experiment, we have pointed out a practical method to estimate the end reflectivity in high-power fiber amplifiers. Based on this estimation, the SBS threshold characters of the high-power narrow-linewidth fiber amplifiers with different end reflectivity and seed linewidths are investigated. By reducing the end reflectivity, a 2.85 times SBS threshold enhancement has been achieved at the most susceptible linewidth (16.8 GHz). Furthermore, we propose a spectral evolution model to investigate the SBS threshold in high-power narrow-linewidth fiber amplifiers, which is even capable for calculating SBS thresholds of the systems with tens of GHz linewidth while weak end reflection is considered. The simulation results demonstrate that end reflection will obviously affect the SBS threshold when the linewidth of the seed laser is broadened beyond 5 GHz, especially for the spectral linewidth of seed lasers nearing the Brillouin frequency shift. Besides, when the end reflectivity is set to be stronger than -65 dB, the SBS threshold performs a tendency to decline and then rise with the growth of seed linewidth. The experiment and simulation results provide a new optimization sight for the SBS effect suppression in high-power narrow-linewidth fiber amplifiers.

5†kW power-level 1050†nm narrow-linewidth fiber amplifier enabled by biconical-tapered active fiber.

Effective wavelength extension is vital in the applications of high-power narrow-linewidth fiber lasers. In this work, we demonstrate a 5-kW power-level narrow-linewidth fiber amplifier at 1050 nm utilizing a homemade biconical-tapered Yb-doped fiber (BT-YDF). Up to ∼4.96 kW fiber laser is achieved with a 3 dB linewidth of ∼0.54 nm and a beam quality factor of Mx 2 = 1.46, My 2 = 1.6. The experimental comparisons reveal that BT-YDF has the advantages of improving a stimulated Raman scattering threshold and balancing transverse mode instability suppression in the fiber amplifier. This work could provide a good reference for extending the operating wavelength of high-power fiber amplifiers.

Confined-doped fiber enabled kilowatt-level all-fiber laser with 1.28†GHz linewidth.

In this manuscript, a narrow linewidth fiber amplifier based on confined-doped fiber is established, and the power scaling and beam quality maintaining capabilities of this amplifier are investigated. Benefitted from the large mode area of the confined-doped fiber and precisely controlling the Yb-doped region in the fiber core, the stimulated Brillouin scattering (SBS) and transverse mode instability (TMI) effects are effectively balanced. As a result, a 1007 W signal laser with just 1.28 GHz linewidth is obtained by combining the advantages of confined-doped fiber, near-rectangular spectral injection, and 915 nm pump manner. As far as we know, this result is the first beyond kilowatt-level demonstration of all-fiber lasers with GHz-level linewidth, which could provide a well reference for simultaneously controlling spectral linewidth, suppressing the SBS and TMI effects in high-power, narrow-linewidth fiber lasers.

All-fiberized linearly polarized superfluorescent fiber source with 5 kW power output.

A superfluorescent fiber source (SFS) is a special fiber source that commonly possesses high temporal stability and a wide spectral linewidth. In this work, an all-fiberized linearly polarized SFS with, to our knowledge, record output power and near-diffraction-limited beam quality is presented. Up to 5.03 kW SFS is achieved at a pump power of 6.18 kW with a corresponding conversion efficiency of ∼81.1%. At maximum output power, the signal-to-noise ratio to background spectral noise is over 50 dB, the polarization extinction ratio is ∼17d B, and the beam quality factor is M x 2=1.49, M y 2=1.44. Further comparisons confirm the power scalability of fiber amplifiers employing SFSs as seed lasers. Overall, this work could provide a good reference for potential exploration of high-power fiber laser systems.

Threshold of transverse mode instability considering four-wave mixing.

In this work, the influence of four-wave mixing (FWM) effects on the transverse mode instability (TMI) is incorporated into the TMI model based on stimulated thermal Rayleigh scattering. The model is capable of analyzing the gain characteristics of different high-power fiber amplifiers, based on which the physical mechanism and functioning boundary of FWM are theoretically investigated. Consequently, a new TMI threshold formula is defined to resolve the inconsistencies in the previous TMI models. It is revealed that it is extremely necessary to consider the influence of FWM on TMI in ultra-large mode field laser systems.

694 W sub-GHz polarization-maintained tapered fiber amplifier based on spectral and pump wavelength optimization.

The comprehensive suppression of the stimulated Brillouin scattering (SBS) and transverse mode instability (TMI) is a critical issue for the power scaling of fiber laser with sub-GHz spectral linewidth. In this manuscript, a narrow linewidth and polarization-maintained (PM) fiber amplifier based on tapered Yb-doped fiber (T-YDF) is established, and the effects of spectral linewidth, spectral shape and pump wavelength on the SBS and/or TMI thresholds are investigated. Up to 694 W polarization-maintained fiber laser with just ∼790 MHz linewidth is obtained by combining the advantages of tapered Yb-doped fiber, near-rectangular spectral injection and 915 nm pump manner. This work could provide a well reference solution for the realization of high-power ultra-narrow linewidth fiber lasers.

Experimental study on the impact of signal bandwidth on the transverse mode instability threshold of fiber amplifiers.

In this work, we conduct a detailed experimental study on the impact of signal bandwidth on the TMI threshold of fiber amplifiers. Both the filtered superfluorescent fiber sources and the phase-modulated single-frequency lasers are employed to construct seed lasers with different 3 dB spectral linewidths ranging from 0.19 nm to 7.97 nm. The TMI threshold of the fiber amplifier employing those seed lasers are estimated through the intensity evolution of the signal laser, and different criteria have been utilized to characterize the spectral linewidth of the seed lasers. Notably, the experimental results reveal that the TMI threshold of fiber amplifiers grows, keeps constant, and further grows as a function of spectral linewidth of seed lasers. Our experimental results could provide a well reference to understand the mechanism of the TMI effect and optimize the TMI effect in high-power fiber amplifiers.

Confined-doped active fiber enabled all-fiber high-power single-frequency laser.

In this paper, we investigate the performances of an in-house fabricated confined-doped active fiber in the applications of all-fiber high-power single-frequency amplifiers. A 210-W single-frequency single-mode fiber laser is obtained directly, which confirms the excellent performance of the confined-doped active fiber for high-power single-mode operation. To further demonstrate the power scalability of the fiber amplifier, the strategy of applying a temperature gradient along the active fiber is investigated numerically and experimentally, and an up to ∼75% enhancement of the stimulated Brillouin scattering (SBS) threshold is achieved. As a result, a 368-W single-frequency fiber laser is obtained with the beam quality factor of Mx2 = 1.19, My2 = 1.26. Overall, the technique of the confined-doped active fiber provides a promising approach to scale the output power of single-frequency single-mode fiber lasers.

3 kW power-level all-fiberized superfluorescent fiber source with linear polarization and near-diffraction-limited beam quality.

In this paper, we demonstrate a high-power linearly polarized all-fiberized superfluorescent fiber source (SFS) with near-diffraction-limited beam quality. The laser system is based on a master oscillator power amplifier configuration, which mainly consists of a polarization-maintained (PM) broadband SFS and multistage PM fiber amplifiers. A linearly polarized fiber laser over 3 kW is obtained at a pump power of about 4.3 kW with the corresponding slope efficiency of 71.9%. The polarization extinction ratio and the beam quality (M2 factor) of the output laser are about 12.7 dB and 1.18, respectively, at the maximum output power. To the best of our knowledge, this is the highest output power of a linearly polarized broadband SFS with near-diffraction-limited beam quality.

532†nm pump induced photo-darkening inhibition and photo-bleaching in high power Yb-doped fiber amplifiers.

A novel method for mitigating photo-darkening and the effective photo-bleaching phenomenon by 532 nm cladding pump in Yb-doped fiber were herein reported. Compared with the pristine fiber, beyond 30% of photo-darkening induced excess loss was suppressed by 532 nm pretreatment. Moreover, the excess loss in the photo-darkened fiber was completely bleached with 532 nm pump. Additionally, the bleached fiber exhibited better photo-darkening resistance. Therefore, for high power application, a 20/400 gamma irradiated fiber was bleached in situ by 532 nm pump and the laser properties were explored. The output power restored to 421W accounting for 82% of the pristine fiber, with the mode instability threshold rising to over 2.6 times and the efficiency increasing from 37% to 63%. The results indicate 532 nm pump has bright prospects for the stable operation of high power fiber lasers.

Mitigation of mode instability in laser oscillators based on deuterium loading.

Ytterbium-doped fiber (YDF) loaded with deuterium is used herein to mitigate mode instability. Experimental results reveal that this method can increase the mode instability threshold in a laser oscillator. Specifically, when the YDF was loaded with deuterium over two- and four-week periods, the mode instability threshold power increased from ∼459 W to ∼533 W (16%) and to ∼622 W (35%), respectively, but the respective laser efficiencies were almost unaffected (71.5% vs. 72.9% and 75.4%). In conclusion, deuterium loading is effective in the mitigation of mode instability. It is envisaged to be applied in the power scaling of high-power fiber lasers.

Confined-doped fiber for effective mode control fabricated by MCVD process.

A confined-doped fiber was fabricated by a modified chemical vapor deposition (MCVD) process based on refractive index matching technology. With theory and experiments, we compared the confined-doped fiber and normal-doped fiber. We found that the confined-doped fiber with a core of 35 µm and 0.07 numerical aperture could achieve single-mode output and improve the beam quality from 2.8 to 1.5 in the fiber laser. Meanwhile, it still possesses high laser efficiency and has good stability of beam quality with the increase in pump power. It suggests that the confined-doped fiber with a MCVD process may be the key material for a high-power fiber laser with excellent beam quality.

3.96 kW All-Fiberized Linearly Polarized and Narrow Linewidth Fiber Laser with Near-Diffraction-Limited Beam Quality.

In this paper, we realize a 3.96 kW all-fiberized and polarization-maintained (PM) amplifier with narrow linewidth and near-diffraction-limited beam quality. Based on a master oscillator power amplifier (MOPA) configuration seeded with phase-modulated single-frequency laser, a 3.96 kW signal laser is achieved with a 3 dB linewidth of 0.62 nm at the pump power of 5.02 kW. At the maximum output power, the polarization extinction ratio (PER) is ~13.9 dB, and the beam quality (M2 factor) is M2x = 1.31, M2y = 1.41. As far as we know, this is the maximum output power of PM narrow linewidth fiber laser with near-diffraction-limited beam quality and all-fiber format.

Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs.

Photothermal therapy (PTT) was considered as one of the most promising cancer therapies to overcome the severe side effects caused by chemotherapy. Hence, four thiophene analogs were developed to construct novel organic photothermal agents (PTAs) for many biomedical applications in cancer biosensing and photothermal therapies. The efficacy of four compounds was demonstrated by studies of photothermal properties as well as photothermal therapeutic effects. Besides, tumor ablation experiments indicated that HTN2 can effectively suppress tumors in vivo and in vitro as a novel PTA. Hence, PTAs that we designed and synthesized with their advantage of good biocompatibility and facile structural design could be candidates for PTT.

A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity.

Lipid droplets (LDs) are multi-functional organelles with the storage of lipid and participating in a variety of physiological processes, including membrane transport and signal transduction. The dysfunction of LDs has been reported to be associated with multiple diseases such as obesity, diabetes, atherosclerosis, and cancer in research. Herein, we designed and synthesized a family of push-pull bio-probes (LDP1-LDP4) based on thiophene or 3,4-ethylenedioxythiophene, which is also called EDOT. LDP1-LDP4 showed positive solvatochromic effect from toluene to ethanol and the maximum fluorescence wavelength redshifted to 165 nm. It was found that the four probes showed significant increase in fluorescence intensity from PBS to oil. LDP1-LDP4 displayed excellent biocompatibility and good optical properties and had substantially facilitated to track LDs with detecting heterogeneity. LDP4 was also used to expose the difference in the polarity of LDs and cytoplasm.

GSH-Activated Light-Up Near-Infrared Fluorescent Probe with High Affinity to αvß3 Integrin for Precise Early Tumor Identification.

The development of tumor-associated, stimuli-driven, turn-on near-infrared (NIR) fluorophores requires urgent attention because of their potential in selective and precise tumor diagnosis. Herein, we describe a NIR fluorescent probe (CyA-cRGD) comprised of a fluorescence reporting unit (a cyanine dye) linked with a GSH-responsive unit (nitroazo aryl ether group) and a tumor-targeting unit (cRGD). The NIR fluorescence of CyA-cRGD with sensitive and selective response to GSH can act as a direct off-on signal reporter for GSH monitoring. Notably, CyA-cRGD possesses improved biocompatibility compared with CyA, which is highly desirable for in vivo fluorescence tracking of cancer. Confocal fluorescence imaging confirmed the tumor-targeting capability and GSH detection ability of CyA-cRGD in tumor cells, normal cells, and coincubated tumor /normal cells and in the three-dimensional multicellular tumor spheroid. Furthermore, it was validated that CyA-cRGD could detect tumor precisely in GSH and integrin αvß 3 high-expressed tumor-bearing mouse models. Importantly, it was confirmed that CyA-cRGD possessed high efficiency for early-stage tumor imaging in mouse models with tumor cells implanted within 72 h. This method provided significant advances toward more in-depth understanding and exploration of tumor imaging, which may potentially be applied for clinical early tumor diagnosis.

Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy.

Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine. CuS-apoferritin was prepared by a biomimetic synthesis method by using the inside cavity of apoferritin to control the size of CuS nanoparticles. Then, a water-soluble near infrared (NIR) dye (MBA) was bound with CuS-apoferritin, forming a nanocomplex (CuS-apoferritin-MBA) with greatly enhanced photothermal conversion efficiency compared to CuS-apoferritin. The unique optical behavior of CuS-apoferritin-MBA enables fluorescence imaging and photothermal therapy at separated optical wavelengths both, with optimized performances. CuS-apoferritin-MBA was then utilized as a photothermal agent for imaging-guided photothermal therapy in tumor-bearing mouse models. As revealed by in vivo fluorescence imaging, CuS-apoferritin-MBA showed high tumor uptake owing to an enhanced permeability and retention effect and the active targeting of apoferritin. In vivo photothermal therapy experiments indicated that tumors could be ablated by combining CuS-apoferritin-MBA with irradiation of an 808 nm laser. Thus, our work presents a safe, simple photothermal nanocomplex, promising for future clinical translation in cancer treatment.