Detalhe da pesquisa
1.
Antibody-mediated activation of the FGFR1/Klothoß complex corrects metabolic dysfunction and alters food preference in obese humans.
Proc Natl Acad Sci U S A
; 117(46): 28992-29000, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139537
2.
Correction to: Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis.
Pharm Res
; 37(3): 41, 2020 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980965
3.
Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis [corrected].
Pharm Res
; 37(2): 25, 2020 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31907670
4.
Absence of Pharmacokinetic Interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate.
J Pharmacol Exp Ther
; 371(1): 202-207, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371481
5.
In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound.
Mol Pharm
; 15(4): 1607-1617, 2018 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29522347
6.
Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria.
Mol Pharm
; 14(10): 3577-3587, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28834434
7.
Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab.
CPT Pharmacometrics Syst Pharmacol
; 13(4): 544-550, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38343040
8.
Effects of Quinidine or Rifampin Co-administration on the Single-Dose Pharmacokinetics and Safety of Rilzabrutinib (PRN1008) in Healthy Participants.
Clin Pharmacol Drug Dev
; 13(6): 590-600, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38623935
9.
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
Pharmacogenet Genomics
; 23(11): 591-6, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23982262
10.
Genome-wide association study implicates PARD3B-based AIDS restriction.
J Infect Dis
; 203(10): 1491-502, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21502085
11.
Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection.
J Infect Dis
; 202(12): 1836-45, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21083371
12.
Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial.
Nat Med
; 27(11): 1961-1969, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750553
13.
Efficacy, Safety, and Pharmacodynamic Effects of the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.
Arthritis Rheumatol
; 73(10): 1835-1846, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34042314
14.
Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila.
J Neurosci
; 29(11): 3538-50, 2009 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19295159
15.
Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI.
Clin Pharmacol Ther
; 107(1): 269-277, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31376152
16.
Understanding the Effect of Hydroxypropyl-ß-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.
Clin Pharmacol Ther
; 108(6): 1224-1232, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32535897
17.
Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.
CPT Pharmacometrics Syst Pharmacol
; 9(6): 332-341, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32383787
18.
Fenebrutinib versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial (ANDES Study).
Arthritis Rheumatol
; 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32270926
19.
Substrate-dependent effects of human ABCB1 coding polymorphisms.
J Pharmacol Exp Ther
; 325(2): 435-42, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287207
20.
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
J Pharmacol Exp Ther
; 325(3): 859-68, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364470