Detalhe da pesquisa
1.
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?
Annu Rev Pharmacol Toxicol
; 60: 529-551, 2020 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31506008
2.
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.
Toxicol Appl Pharmacol
; 459: 116342, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36502871
3.
Molecular Mechanisms Provide a Landscape for Biomarker Selection for Schizophrenia and Schizoaffective Psychosis.
Int J Mol Sci
; 24(20)2023 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37894974
4.
Molecular Mechanism Biomarkers Predict Diagnosis in Schizophrenia and Schizoaffective Psychosis, with Implications for Treatment.
Int J Mol Sci
; 24(21)2023 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37958826
5.
Evolving the Role of Discovery-focused Pathologists and Comparative Scientists in the Pharmaceutical Industry.
Toxicol Pathol
; 47(2): 121-128, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30651043
6.
Ocular tissue distribution and pharmacokinetic study of a small 13kDa domain antibody after intravitreal, subconjuctival and eye drop administration in rabbits.
Exp Eye Res
; 167: 14-17, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074387
7.
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.
Chem Res Toxicol
; 31(11): 1119-1127, 2018 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30350600
8.
Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse.
J Toxicol Pathol
; 29(3 Suppl): 1S-47S, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621537
9.
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes.
Cell Stem Cell
; 31(3): 292-311, 2024 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366587
10.
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging.
Toxicol Sci
; 195(1): 61-70, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462734
11.
The in vivo rat skin photomicronucleus assay: phototoxicity and photogenotoxicity evaluation of six fluoroquinolones.
Mutagenesis
; 27(6): 721-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935223
12.
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.
Stem Cell Reports
; 17(3): 556-568, 2022 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35148844
13.
Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.
Drug Metab Dispos
; 38(1): 143-9, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19797606
14.
Development and characterization of an in vivo skin photomicronucleus assay in rats.
Mutagenesis
; 25(4): 407-16, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20460329
15.
Time course characterization of serum cardiac troponins, heart fatty acid-binding protein, and morphologic findings with isoproterenol-induced myocardial injury in the rat.
Toxicol Pathol
; 38(5): 703-14, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20585145
16.
Improved method for the catheterization of the right ventricle in a rat model of pulmonary artery hypertension.
Interact Cardiovasc Thorac Surg
; 30(4): 535-537, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31965143
17.
Dual-locus DNA metabarcoding reveals southern hairy-nosed wombats (Lasiorhinus latifrons Owen) have a summer diet dominated by toxic invasive plants.
PLoS One
; 15(3): e0229390, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142513
18.
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format.
Stem Cell Reports
; 15(4): 983-998, 2020 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33053362
19.
Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Toxicol Sci
; 176(1): 224-235, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32298455
20.
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Toxicol Sci
; 176(1): 103-123, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32421822