Pesquisa | BVS Violência e Saúde

1.

Transcription factor protein interactomes reveal genetic determinants in heart disease.

Gonzalez-Teran, Barbara; Pittman, Maureen; Felix, Franco; Thomas, Reuben; Richmond-Buccola, Desmond; Hüttenhain, Ruth; Choudhary, Krishna; Moroni, Elisabetta; Costa, Mauro W; Huang, Yu; Padmanabhan, Arun; Alexanian, Michael; Lee, Clara Youngna; Maven, Bonnie E J; Samse-Knapp, Kaitlen; Morton, Sarah U; McGregor, Michael; Gifford, Casey A; Seidman, J G; Seidman, Christine E; Gelb, Bruce D; Colombo, Giorgio; Conklin, Bruce R; Black, Brian L; Bruneau, Benoit G; Krogan, Nevan J; Pollard, Katherine S; Srivastava, Deepak.

Cell ; 185(5): 794-814.e30, 2022 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-35182466

2.

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Sachdev, Aradhana; Gill, Kamaljot; Sckaff, Maria; Birk, Alisha M; Aladesuyi Arogundade, Olubankole; Brown, Katherine A; Chouhan, Runvir S; Issagholian-Lewin, Patrick Oliver; Patel, Esha; Watry, Hannah L; Bernardi, Mylinh T; Keough, Kathleen C; Tsai, Yu-Chih; Smith, Alec Simon Tulloch; Conklin, Bruce R; Clelland, Claire Dudley.

Proc Natl Acad Sci U S A ; 121(17): e2307814121, 2024 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-38621131

3.

Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.

Zhu, Lili; Choudhary, Krishna; Gonzalez-Teran, Barbara; Ang, Yen-Sin; Thomas, Reuben; Stone, Nicole R; Liu, Lei; Zhou, Ping; Zhu, Chenchen; Ruan, Hongmei; Huang, Yu; Jin, Shibo; Pelonero, Angelo; Koback, Frances; Padmanabhan, Arun; Sadagopan, Nandhini; Hsu, Austin; Costa, Mauro W; Gifford, Casey A; van Bemmel, Joke G; Hüttenhain, Ruth; Vedantham, Vasanth; Conklin, Bruce R; Black, Brian L; Bruneau, Benoit G; Steinmetz, Lars; Krogan, Nevan J; Pollard, Katherine S; Srivastava, Deepak.

Circulation ; 146(10): 770-787, 2022 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-35938400

4.

Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.

Iwagawa, Toshiro; Masumoto, Hiroki; Tabuchi, Hitoshi; Tani, Kenzaburo; Conklin, Bruce R; Watanabe, Sumiko.

J Gene Med ; 25(2): e3464, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36413603

5.

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.

Eskildsen, Tilde V; Ayoubi, Sohrab; Thomassen, Mads; Burton, Mark; Mandegar, Mohammed A; Conklin, Bruce R; Jensen, Charlotte H; Andersen, Ditte C; Sheikh, Søren P.

Dev Biol ; 445(1): 1-7, 2019 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-30389344

6.

On the road to a gene drive in mammals.

Conklin, Bruce R.

Nature ; 566(7742): 43-45, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30710124

7.

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.

Ribeiro, Alexandre J S; Schwab, Olivier; Mandegar, Mohammad A; Ang, Yen-Sin; Conklin, Bruce R; Srivastava, Deepak; Pruitt, Beth L.

Circ Res ; 120(10): 1572-1583, 2017 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-28400398

8.

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Hayashi, Yohei; Hsiao, Edward C; Sami, Salma; Lancero, Mariselle; Schlieve, Christopher R; Nguyen, Trieu; Yano, Koyori; Nagahashi, Ayako; Ikeya, Makoto; Matsumoto, Yoshihisa; Nishimura, Ken; Fukuda, Aya; Hisatake, Koji; Tomoda, Kiichiro; Asaka, Isao; Toguchida, Junya; Conklin, Bruce R; Yamanaka, Shinya.

Proc Natl Acad Sci U S A ; 113(46): 13057-13062, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27794120

9.

Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.

Hoang, Plansky; Huebsch, Nathaniel; Bang, Shin Hyuk; Siemons, Brian A; Conklin, Bruce R; Healy, Kevin E; Ma, Zhen; Jacquir, Sabir.

Biotechnol Bioeng ; 115(8): 1958-1970, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-29663322

10.

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.

Hayashi, Yohei; Caboni, Laura; Das, Debanu; Yumoto, Fumiaki; Clayton, Thomas; Deller, Marc C; Nguyen, Phuong; Farr, Carol L; Chiu, Hsiu-Ju; Miller, Mitchell D; Elsliger, Marc-André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Tomoda, Kiichiro; Conklin, Bruce R; Wilson, Ian A; Yamanaka, Shinya; Fletterick, Robert J.

Proc Natl Acad Sci U S A ; 112(15): 4666-71, 2015 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-25825768

11.

Gαi/o-coupled receptor signaling restricts pancreatic ß-cell expansion.

Berger, Miles; Scheel, David W; Macias, Hector; Miyatsuka, Takeshi; Kim, Hail; Hoang, Phuong; Ku, Greg M; Honig, Gerard; Liou, Angela; Tang, Yunshuo; Regard, Jean B; Sharifnia, Panid; Yu, Lisa; Wang, Juehu; Coughlin, Shaun R; Conklin, Bruce R; Deneris, Evan S; Tecott, Laurence H; German, Michael S.

Proc Natl Acad Sci U S A ; 112(9): 2888-93, 2015 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-25695968

12.

Isolation of single-base genome-edited human iPS cells without antibiotic selection.

Miyaoka, Yuichiro; Chan, Amanda H; Judge, Luke M; Yoo, Jennie; Huang, Miller; Nguyen, Trieu D; Lizarraga, Paweena P; So, Po-Lin; Conklin, Bruce R.

Nat Methods ; 11(3): 291-3, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24509632

13.

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.

Park, Jason S; Rhau, Benjamin; Hermann, Aynur; McNally, Krista A; Zhou, Carmen; Gong, Delquin; Weiner, Orion D; Conklin, Bruce R; Onuffer, James; Lim, Wendell A.

Proc Natl Acad Sci U S A ; 111(16): 5896-901, 2014 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-24711398

14.

Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.

Wattanachanya, Lalita; Wang, Liping; Millard, Susan M; Lu, Wei-Dar; O'Carroll, Dylan; Hsiao, Edward C; Conklin, Bruce R; Nissenson, Robert A.

Exp Cell Res ; 333(2): 289-302, 2015 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-25704759

15.

The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.

Taglieri, Domenico M; Johnson, Keven R; Burmeister, Brian T; Monasky, Michelle M; Spindler, Matthew J; DeSantiago, Jaime; Banach, Kathrin; Conklin, Bruce R; Carnegie, Graeme K.

J Mol Cell Cardiol ; 66: 27-40, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24161911

16.

WikiPathways: building research communities on biological pathways.

Kelder, Thomas; van Iersel, Martijn P; Hanspers, Kristina; Kutmon, Martina; Conklin, Bruce R; Evelo, Chris T; Pico, Alexander R.

Nucleic Acids Res ; 40(Database issue): D1301-7, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22096230

17.

Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat.

Perez-Bermejo, Juan A; Reisman, Samuel J; Ma, Joyce; Carrison-Stone, Dana; Cerrito, Chris; Ribeiro, Alexandre J S; Conklin, Bruce R; Yu, Kristina.

Stem Cell Reports ; 19(3): 426-433, 2024 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-38335963

18.

Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.

Chu, Simon N; Soupene, Eric; Wienert, Beeke; Yin, Han; Sharma, Devesh; McCreary, Travis; Jia, Kun; Homma, Shota; Hampton, Jessica P; Gardner, James M; Conklin, Bruce R; MacKenzie, Tippi C; Porteus, Matthew H; Cromer, M Kyle.

bioRxiv ; 2024 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-38766216

19.

GO-Elite: a flexible solution for pathway and ontology over-representation.

Zambon, Alexander C; Gaj, Stan; Ho, Isaac; Hanspers, Kristina; Vranizan, Karen; Evelo, Chris T; Conklin, Bruce R; Pico, Alexander R; Salomonis, Nathan.

Bioinformatics ; 28(16): 2209-10, 2012 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-22743224

20.

Finding the right questions: exploratory pathway analysis to enhance biological discovery in large datasets.

Kelder, Thomas; Conklin, Bruce R; Evelo, Chris T; Pico, Alexander R.

PLoS Biol ; 8(8)2010 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-20824171

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