RESUMO
An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma.
Assuntos
Herpes Simples/complicações , Lesões Pré-Cancerosas , Neoplasias do Colo do Útero/etiologia , Animais , Colo do Útero/patologia , Modelos Animais de Doenças , Feminino , Herpes Simples/patologia , Hiperplasia , Metaplasia , Ratos , Doenças do Colo do Útero/complicações , Doenças do Colo do Útero/patologia , Displasia do Colo do Útero/etiologia , Neoplasias do Colo do Útero/patologia , Doenças Vaginais/complicações , Doenças Vaginais/patologiaAssuntos
Herpes Genital/complicações , Doenças do Colo do Útero/complicações , Neoplasias do Colo do Útero/etiologia , Animais , Azatioprina/efeitos adversos , Colo do Útero/lesões , Dietilestilbestrol/efeitos adversos , Dietilestilbestrol/análogos & derivados , Feminino , Masculino , Ratos , Ratos Endogâmicos , Reserpina/efeitos adversos , Displasia do Colo do Útero/induzido quimicamente , Displasia do Colo do Útero/etiologia , Neoplasias do Colo do Útero/induzido quimicamenteRESUMO
Gastric biopsies were obtained from 125 subjects to compare detection of Helicobacter pylori by culture, a rapid urease test and histopathologic examination using haematoxylin-eosin, Gram, Giemsa, Warthin-Starry silver and acridine orange stains. Helicobacter pylori was isolated from 39 specimens. Acridine orange and Giemsa were the most sensitive stains, detecting 85% and 79% of positive specimens respectively. All stains showed high specificity (97-100%). The sensitivity and specificity of the rapid urease test was 62% and 100% respectively. These stains or the rapid urease test may be useful for rapid detection of Helicobacter pylori in gastric biopsies.
Assuntos
Bactérias Anaeróbias Gram-Negativas/isolamento & purificação , Antro Pilórico/microbiologia , Coloração e Rotulagem , Urease/metabolismo , Biópsia , Distribuição de Qui-Quadrado , Bactérias Anaeróbias Gram-Negativas/enzimologia , Humanos , Valor Preditivo dos TestesRESUMO
Endometriosis is a common disorder, affecting women in the child-bearing years. While urologic involvement is rare, the bladder is more often affected than the ureter. The authors describe the case of a 30-year-old woman who had unilateral ureteral obstruction secondary to an isolated periureteral retroperitoneal area of endometriosis. The theories of histogenesis are discussed. Current treatment consists of surgery or hormonal manipulation or a combination of the two.
Assuntos
Endometriose/complicações , Neoplasias Retroperitoneais/complicações , Obstrução Ureteral/etiologia , Adulto , Difosfonatos , Endometriose/diagnóstico por imagem , Endometriose/cirurgia , Feminino , Humanos , Hidronefrose/complicações , Hidronefrose/etiologia , Cintilografia , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/cirurgia , Tecnécio , Medronato de Tecnécio Tc 99m , Ultrassonografia , Obstrução Ureteral/diagnóstico por imagem , Obstrução Ureteral/cirurgiaRESUMO
Thirty-two young women who desired sexual reassignment were treated with large doses of androgen for a period of 1 year or more, followed by total hysterectomy. Histological examination revealed marked atrophy of cervical epithelium which could mimic dysplasia, and variable degrees of endometrial atrophy. The ovaries showed occasional corpora lutea indicating that even in the face of long term androgen therapy, ovulation may occur.
Assuntos
Androgênios/uso terapêutico , Genitália Feminina/patologia , Transexualidade/patologia , Adulto , Atrofia , Carcinoma de Células Escamosas/patologia , Colo do Útero/efeitos dos fármacos , Colo do Útero/patologia , Endométrio/efeitos dos fármacos , Endométrio/patologia , Feminino , Genitália Feminina/efeitos dos fármacos , Humanos , Pessoa de Meia-Idade , Mucosa/efeitos dos fármacos , Mucosa/patologia , Ovário/efeitos dos fármacos , Ovário/patologia , Coloração e Rotulagem , Neoplasias do Colo do Útero/patologiaRESUMO
We describe a patient who developed fatal bronchiolitis obliterans following gold therapy and review the relationship between rheumatoid arthritis and bronchiolitis.
Assuntos
Bronquite/induzido quimicamente , Tiomalato Sódico de Ouro/efeitos adversos , Idoso , Artrite Reumatoide/tratamento farmacológico , Brônquios/patologia , Bronquite/patologia , Humanos , Masculino , Testes de Função RespiratóriaRESUMO
To determine the prevalence of Campylobacter pylori colonization in the healthy population we studied 54 asymptomatic volunteers and 65 patients referred because of gastrointestinal symptoms. All subjects underwent gastroscopy and gastric biopsy. C. pylori was isolated from 6 volunteers (11%) and 36 patients (55%). Histologic evidence of inflammation was present in 98% of the culture-positive subjects. Linear regression analysis revealed that the prevalence of C. pylori colonization increased with age. There was no difference in the isolation rate between the two groups when adjusted for age. Four of the six culture-positive volunteers underwent repeat endoscopy and gastric biopsy 1 year later; despite remaining asymptomatic, all still had positive culture results and histologic evidence of gastritis. We conclude that the prevalence of C. pylori-associated gastritis among symptomatic patients increases with age and that the organism may be present in the gastrointestinal tract for prolonged periods without symptoms or evidence of disease progression.