Recurrent intracerebral hemorrhage.

Between 1984 and 1994, of the 375 patients admitted to our department for intracerebral hemorrhage (ICH), 24 (6.4%) had a recurrent ICH. There were 15 women and nine men and the mean age of the patients was 64.7 +/- 9.4 years (range 49-81) at the first bleeding episode and 68.7 +/- 7.5 years (range 57-83) at the second. The mean interval between the two bleeding episodes was 47.5 +/- 30.5 months (range 3 months to 14.8 years). Nine patients presented with more than one recurrence of ICH. Seventy-one percent of the patients were hypertensive. The site of the first hemorrhage was lobar in 17 patients, ganglionic (putamen, thalamus, or caudate nucleus) in six patients, and subdural in one. The recurrent hemorrhage occurred at a different location from the previous ICH. The most common pattern of recurrence was "lobar-lobar" (14 patients) and more rarely "ganglionic-ganglionic" (five patients), which was always observed in hypertensive patients. The outcome after the recurrent hemorrhage was usually poor, with severe cognitive impairment. By comparison with 81 patients followed up to 24 months (47.9 +/- 22.2 months) with isolated ICH without recurrence, only lobar hematoma and a younger age were risk factors for recurrences whereas sex and previous hypertension were not. The mechanisms of recurrence of ICH were multiple (hypertension, cerebral amyloid angiopathy). Control of blood pressure after the first hemorrhage may prevent ICH recurrences.

Usefulness of a quantitative analysis of the recovery phase patterns of the ST-segment depression in the diagnosis of coronary artery disease.

PURPOSE: To assess the diagnostic value of the recovery phase patterns of the ST-segment depression in patients referred for chest pain. PATIENTS AND METHODS: Continuous plots of ST-segment depression against heart rate during exercise and recovery were constructed within a population of 160 consecutive symptomatic patients who all had undergone catheterization (80 with > or = 1 stenosis > or = 50%). We used a new quantitative method of measurement allowing all kinds of rate recovery loops (even the so-called "intermediate" loops) to be considered for analysis. The measurements of the heart rate (HR)-adjusted ST-segment depression were performed at 20 and 60 ms from the J point, providing two different values of a quantified recovery loop index (RLI): RLI 20 and RLI 60. RESULTS: Both RLI showed a higher specificity (0.81 +/- 0.04 and 0.74 +/- 0.05, respectively) than did the standard criterion (0.65 +/- 0.10), but the difference was significant regarding RLI 20 only (P = 0.011). As to the sensitivity, no significant differences were found among all of the criteria (0.74 +/- 0.05, 0.80 +/- 0.04, 0.76 +/- 0.05, respectively). The timing of measurements of the RLI within the repolarization phase did not affect their overall accuracy (0.77 +/- 0.03 for both RLI). The values of the receiver-operating characteristic (ROC) curve areas were significantly greater for both RLI (0.83 +/- 0.06 and 0.84 +/- 0.06 respectively) than for the standard criterion (0.75 +/- 0.07; P < 0.02). Finally, both RLI allowed to differentiate accurately the study subjects according to the number of diseased vessels, whereas the standard criterion could only distinguish between CAD patients and subjects with normal angiograms. CONCLUSION: The quantitative analysis of the rate recovery phase patterns appears to be useful for the diagnosis of coronary heart disease and the assessment of its severity in symptomatic patients.

[Echocardiographic assessment of the left ventricular fractional shortening/end-systolic stress relation in untreated hypertensive patients]. / Mesure échocardiographique de la relation fraction de raccourcissement/contrainte télésystolique du ventricule gauche chez l'hypertendu non traité.

UNLABELLED: The present study was designed to assess the left ventricular (LV) function by the fractional shortening (FS)/end-systolic stress (ESS) relation in untreated hypertensive patients. METHODS: Two patient groups were examined: group 1 was made up of 50 patients with essential mild hypertension (44 +/- 14 years) and group 2 consisted of 16 normotensives (35 +/- 12 years). LV mass, endocardial FS, mid-wall FS and meridional ESS were measured according to the classic formulas, as well as the 24-hour ambulatory blood pressure (ABP). FS/ESS relation was analysed in hypertensive patients by 2 different ways: 1 degree graphically, with the 95% confidence interval of the normal FS/ESS relation as a reference: 2 degrees statistically, by comparing the observed FS values with those FS value expected from ESS, using equations derived from normal subjects (McMemar chi 2 test, or binomial rule). RESULTS: The graphic examination allowed for the identification of a depressed, normal or increased LV function in, respectively, 7, 31 and 12 patients, using the endocardial FS/ESS relation, against 30, 18 and 2 patients, using the mid-wall FS/ESS relation. Likewise, the statistical analysis of the differences between the observed FS values and the expected FS values showed 13 discrepancies, all of them being related to an overestimation of the LV function, an assessed by the endocardial FS/ESS relation (p < 0.01). Such a trend turned out to be more significant in patients with an increased ABP (n = 31; p < 0.05) than in "white coat" hypertensives (n = 9; p < 0.08): in contrast, it was of the same extent in patients with an increased LV mass (n = 17; p < 0.05) as in those with a normal LV mass (n = 33; p < 0.05). CONCLUSIONS: 1/After adjustment for ESS, mid-wall FS (a direct measure of myocardial fiber shortening) was more often decreased than endocardial FS (reflecting chamber dynamics). 2/Mid-wall FS was also found to be a better tool for assessing LV function in patients with normal LV mass, and, to a lesser extent, in "white coat" hypertensives.

[Traumatic coronary dissection caused by deceleration. Report of a case]. / Dissection coronaire traumatique par décélération. A propos d'un cas.

Myocardial infarction is a rare complication of traumatic thoracic deceleration. The authors report the case of anterior myocardial infarction with dissection of the left anterior descending artery in a 16 year old boy who was injured in a motorbike accident without a penetrating thoracic wound. Therefore, the only pathological mechanism was deceleration. The authors review the 12 previously reported cases.

[Pathological laughter after the brainstem infarction]. / Fou rire prodromique d'une occlusion du tronc basilaire.

We report a case of 'fou rire prodromique' heralding a brainstem infarct with favorable prognosis after thrombolysis. Different clinical forms of pathological laughter, the pathophysiological mechanisms and clinico-anatomical correlations of this rare phenomenon are discussed.

[Bilateral medial medullary infarction]. / Infarctus bulbaire médian bilatéral.

We report a case of a 42-year old man with a bilateral medial medullary stroke (MMS) with favorable outcome. First described by Spiller in 1908, the MMS accounts for less than 0,5% of all cerebral infarcts. It may be unilateral or more rarely bilateral, and may often be the consequence of the atherosclerosis. The clinical features of MMS classically associate contralateral hemiparesis and lemniscal hypoesthesia accompanied by ipsilateral lingual palsy and sometimes oculomotor disturbances (upbeat nystagmus). With the advent of magnetic resonance imaging, some restricted or unusual clinical manifestations can be attributed to this localization. The benign form of MMS seems much more common than MMS with poor prognosis.

[Papillary fibroelastoma. A rare etiology of strokes in young patients]. / Fibroélastome papillaire. Une étiologie rare des accidents vasculaires cérébraux du sujet jeune.

BACKGROUND: The papillary fibroelastomas are cardiac lesions, which typically occur on the cardiac valves, but rarely on the endocardium. The incidence of these benign primitive tumors varies from 0.002 to 0.33% and increases with advancing age. METHODS: We report two cases of stroke, one in a 31-year-old man and the other in a 48-year-old woman, both admitted to the same stroke center. RESULTS: The diagnostic studies were normal in these two patients, except for the echocardiography. The first showed an echogenic mass on the mitral valve on transthoracic echocardiography (TTE), confirmed by the transesophageal echocardiography (TEE). The second demonstrated a mass on the sigmoid aortic valve on TEE, but the TTE was normal. For these two patients, a surgical excision was carried out and pathologic examination concluded to a papillary fibroelastoma. After surgery, no recurrence was observed. CONCLUSIONS: The papillary fibroelastomas are usually asymptomatic and easily detected by TEE. However, it can be revealed by stroke, myocardial infarction and lower limbs ischemia. These cardiac tumors should be surgically removed, since their complete excision remains the only means of avoiding a recurrence of embolism.

[Cerebral ischemic disorders in the young subject. Epidemiologic and prognostic data]. / Accidents ischémiques cérébraux du sujet jeune. Données épidémiologiques et pronostiques.

A COMMON EVENT: Cerebral vascular events in young subjects account for 5 to 15% of all such cases admitted to specialized services. The incidence of cerebral vascular events in young subjects varies from 3 to 40 per 100,000 depending on the study period (incomplete explorations in early studies), the study site (industrialized or developing country) and the ethnic background of the population. A HETEROGENEOUS GROUP: Although cerebral vascular events are defined as those occurring in subjects aged 18 to 45 years, the population is nevertheless quite heterogeneous due to rising incidence after 35 years and variable frequency of age-dependent and site-dependent underlying causes. RELATIVELY GOOD PROGNOSIS: Early mortality is relatively low (approximately 5%) and two-thirds of the subjects suffer minor or mild sequellae. However, depression, which is frequent, and the impossibility to return to normal work activities have an important impact on quality of life.

Intracranial hemorrhage and oral anticoagulant treatment.

OBJECTIVE: To detect risk factors for intracranial hemorrhage (ICH) in patients with long-term oral anticoagulant and to identify clinical or radiological data specific of anticoagulant-related ICH. METHODS AND PATIENTS: Three groups of patients were included. Group 1 represents patients who were admitted because of anticoagulant-related ICH between January 1984 and February 1996. All patients underwent CT scan. Clinical data, anticoagulation parameters, location and volume of the ICH, treatment and the 30-days in-hospital mortality were analyzed. Group 2 consisted of patients selected at random among all patients with spontaneous ICH admitted to our department during the same period of time. Patients without ICH, but regularly taking oral anticoagulants constituted group 3. RESULTS: Seventy-nine patients with anticoagulant-related ICH were compared to 127 patients with spontaneous ICH. The volume of supratentorial ICH was greater in group 1 of patients and was correlated with a worse prognosis. Comparison of group 1 with group 3 (212 controls) demonstrated that length of anticoagulation, prothrombin time or excessive anticoagulation, prior cerebral infarct and use of acénocoumarol, but not age or indication of anticoagulant, were significant risk factors for ICH in multivariate analysis. CONCLUSIONS: The results emphasize that anticoagulant-related ICH are not clinically different from spontaneous ICH except for volume of bleeding, and that frequent and careful coagulation monitoring is needed, especially during the first year in order to decrease the risk of ICH.

Functional recovery and social outcome after cerebral infarction in young adults.

This study was designed to assess the return to work, the poststroke depression and the quality of life after a cerebral infarction in young adults and was conducted on 71 consecutive young patients (aged 15-45 years) affected by a cerebral infarct who were hospitalized for the first time and discharged at least 1 year before the study. Data about risk factors, etiology, side and territory of stroke, social characteristics of the patient (age, sex, profession, educational level, family situation), poststroke seizures, recurrent stroke, other vascular events, and deaths were collected. Neurological deficits were graded with the National Institutes of Health (NIH) Stroke Scale. Poststroke depression (PSD) was quantified using the DSM-IIIR criteria and the Montgomery Asberg Depression Rating Scale. Outcomes were rated with the Ranking Scale, the Barthel Index and the Glasgow Outcome Scale. Quality of life was assessed with the Sickness Impact Profile. Follow-up information was obtained by interview and neurological examination. Follow-up information was obtained in 65 patients at a mean of 31.7 +/- 13.0 (range 12-59) months, as 2 patients died and 4 were lost to follow-up and were thus excluded from this study. Poststroke seizures occurred in 7 patients (10.8%) and recurrent strokes in 4 patients (6.2%), but none were fatal. The outcome after stroke among survivors was usually good, since more than two-thirds of the patients (69.8%) reported no problem, 11.1% moderate handicap and one-fifth major handicap. Forty-six patients (73%) returned to work: the time period ranging from several days after stroke to 40 months, with a mean of 8 months. However, adjustments in their occupation were necessary for 12 patients (26.1%). PSD was common, since 48.31% of the patients were classified as depressed. PSD was associated with the localization of the infarct (carotid territory), a severe disability, a bad general outcome, and an absence of return to work. Their opinion about their quality of life was negative among approximately 30% of the patients, especially in emotional and alertness behaviors. social interaction, recreation and pastimes. The general outcome after cerebral infarct in young adults is usually good. However, the risk of a PSD is high, and only half of the patients had returned to their previous work. A remaining psychosocial handicap and depression of sexual activity impaired the quality of life. In multivariate analysis, a low NIH score at admission is a significant predictor for return to work, the absence of PSD, and a good quality of life.

Prevalence and clinical significance of anti-phospholipid antibodies in multiple sclerosis: a study of 89 patients.

The prevalence of serum anti-phospholipid antibodies (aPL) was evaluated in multiple sclerosis (MS) patients to search for a possible association with a distinct form of the disease. Anti-cardiolipin antibodies (Ab) (aCL) and anti-beta 2 glycoprotein I Ab (abeta2GPI) were measured together with antinuclear Ab (ANA), anti-double-stranded DNA Ab (anti-ds DNA) and anti-myelin Ab in 89 patients. Twenty-nine (32.6%) patients had serum aPL, 19xaCL (15 of the IgG and four of the IgM isotype), 14 abeta2GPI (two IgG and 12 IgM) (four of these patients had both Ab). Prevalence of aCL correlated with that of ANA, which were positive in 52 patients (P=0. 005) and with anti-myelin Ab detected in two patients (P=0.046) but not with that of anti-ds DNA (mostly of the IgM class) detected in 28% of case by ELISA. No correlation could be found between aPL and age, sex, duration of the disease from diagnosis, category of MS, clinical course, clinical symptoms, serum IgM levels nor atypical lesions by magnetic resonance imaging. Hence, aCL and abeta2GPI are neither rare in MS nor associated with a specific clinical form of the disease and they cannot be a diagnosis exclusion criteria.