Pesquisa | BVS Violência e Saúde

1.

Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8⁺ T cells.

Corria-Osorio, Jesus; Carmona, Santiago J; Stefanidis, Evangelos; Andreatta, Massimo; Ortiz-Miranda, Yaquelin; Muller, Tania; Rota, Ioanna A; Crespo, Isaac; Seijo, Bili; Castro, Wilson; Jimenez-Luna, Cristina; Scarpellino, Leonardo; Ronet, Catherine; Spill, Aodrenn; Lanitis, Evripidis; Romero, Pedro; Luther, Sanjiv A; Irving, Melita; Coukos, George.

Nat Immunol ; 24(5): 869-883, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37081150

2.

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8⁺ T cell exhaustion.

Tillé, Laure; Cropp, Daniela; Charmoy, Mélanie; Reichenbach, Patrick; Andreatta, Massimo; Wyss, Tania; Bodley, Gabrielle; Crespo, Isaac; Nassiri, Sina; Lourenco, Joao; Leblond, Marine M; Lopez-Rodriguez, Cristina; Speiser, Daniel E; Coukos, George; Irving, Melita; Carmona, Santiago J; Held, Werner; Verdeil, Grégory.

Nat Immunol ; 24(10): 1645-1653, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37709986

3.

Disturbed mitochondrial dynamics in CD8⁺ TILs reinforce T cell exhaustion.

Yu, Yi-Ru; Imrichova, Hana; Wang, Haiping; Chao, Tung; Xiao, Zhengtao; Gao, Min; Rincon-Restrepo, Marcela; Franco, Fabien; Genolet, Raphael; Cheng, Wan-Chen; Jandus, Camilla; Coukos, George; Jiang, Yi-Fan; Locasale, Jason W; Zippelius, Alfred; Liu, Pu-Ste; Tang, Li; Bock, Christoph; Vannini, Nicola; Ho, Ping-Chih.

Nat Immunol ; 21(12): 1540-1551, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33020660

4.

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.

Racle, Julien; Guillaume, Philippe; Schmidt, Julien; Michaux, Justine; Larabi, Amédé; Lau, Kelvin; Perez, Marta A S; Croce, Giancarlo; Genolet, Raphaël; Coukos, George; Zoete, Vincent; Pojer, Florence; Bassani-Sternberg, Michal; Harari, Alexandre; Gfeller, David.

Immunity ; 56(6): 1359-1375.e13, 2023 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-37023751

5.

Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction.

Müller, Markus; Huber, Florian; Arnaud, Marion; Kraemer, Anne I; Altimiras, Emma Ricart; Michaux, Justine; Taillandier-Coindard, Marie; Chiffelle, Johanna; Murgues, Baptiste; Gehret, Talita; Auger, Aymeric; Stevenson, Brian J; Coukos, George; Harari, Alexandre; Bassani-Sternberg, Michal.

Immunity ; 56(11): 2650-2663.e6, 2023 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-37816353

6.

PGE₂ inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.

Morotti, Matteo; Grimm, Alizee J; Hope, Helen Carrasco; Arnaud, Marion; Desbuisson, Mathieu; Rayroux, Nicolas; Barras, David; Masid, Maria; Murgues, Baptiste; Chap, Bovannak S; Ongaro, Marco; Rota, Ioanna A; Ronet, Catherine; Minasyan, Aspram; Chiffelle, Johanna; Lacher, Sebastian B; Bobisse, Sara; Murgues, Clément; Ghisoni, Eleonora; Ouchen, Khaoula; Bou Mjahed, Ribal; Benedetti, Fabrizio; Abdellaoui, Naoill; Turrini, Riccardo; Gannon, Philippe O; Zaman, Khalil; Mathevet, Patrice; Lelievre, Loic; Crespo, Isaac; Conrad, Marcus; Verdeil, Gregory; Kandalaft, Lana E; Dagher, Julien; Corria-Osorio, Jesus; Doucey, Marie-Agnes; Ho, Ping-Chih; Harari, Alexandre; Vannini, Nicola; Böttcher, Jan P; Dangaj Laniti, Denarda; Coukos, George.

Nature ; 629(8011): 426-434, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38658764

7.

Lighting up the tumor fire with low-dose irradiation.

Herrera, Fernanda G; Romero, Pedro; Coukos, George.

Trends Immunol ; 43(3): 173-179, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35105519

8.

Radiotherapy combination opportunities leveraging immunity for the next oncology practice.

Herrera, Fernanda G; Bourhis, Jean; Coukos, George.

CA Cancer J Clin ; 67(1): 65-85, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27570942

9.

Genetics and anatomy sculpt immune-cell partners of ovarian cancer.

Dangaj Laniti, Denarda; Coukos, George.

Nature ; 612(7941): 634-636, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36517683

10.

Sensitive Immunopeptidomics by Leveraging Available Large-Scale Multi-HLA Spectral Libraries, Data-Independent Acquisition, and MS/MS Prediction.

Pak, HuiSong; Michaux, Justine; Huber, Florian; Chong, Chloe; Stevenson, Brian J; Müller, Markus; Coukos, George; Bassani-Sternberg, Michal.

Mol Cell Proteomics ; 20: 100080, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33845167

11.

Structural dissimilarity from self drives neoepitope escape from immune tolerance.

Devlin, Jason R; Alonso, Jesus A; Ayres, Cory M; Keller, Grant L J; Bobisse, Sara; Vander Kooi, Craig W; Coukos, George; Gfeller, David; Harari, Alexandre; Baker, Brian M.

Nat Chem Biol ; 16(11): 1269-1276, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32807968

12.

Deciphering and reversing tumor immune suppression.

Motz, Greg T; Coukos, George.

Immunity ; 39(1): 61-73, 2013 Jul 25.

Artigo em Inglês | MEDLINE | ID: mdl-23890064

13.

Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands.

Solleder, Marthe; Guillaume, Philippe; Racle, Julien; Michaux, Justine; Pak, Hui-Song; Müller, Markus; Coukos, George; Bassani-Sternberg, Michal; Gfeller, David.

Mol Cell Proteomics ; 19(2): 390-404, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31848261

14.

Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Röhrig, Ute F; Majjigapu, Somi Reddy; Vogel, Pierre; Reynaud, Aline; Pojer, Florence; Dilek, Nahzli; Reichenbach, Patrick; Ascenção, Kelly; Irving, Melita; Coukos, George; Michielin, Olivier; Zoete, Vincent.

J Enzyme Inhib Med Chem ; 37(1): 1773-1811, 2022 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-35758198

15.

The C-terminal extension landscape of naturally presented HLA-I ligands.

Guillaume, Philippe; Picaud, Sarah; Baumgaertner, Petra; Montandon, Nicole; Schmidt, Julien; Speiser, Daniel E; Coukos, George; Bassani-Sternberg, Michal; Filippakopoulos, Panagis; Gfeller, David.

Proc Natl Acad Sci U S A ; 115(20): 5083-5088, 2018 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-29712860

16.

Turning up the heat on non-immunoreactive tumours: opportunities for clinical development.

Ochoa de Olza, María; Navarro Rodrigo, Blanca; Zimmermann, Stefan; Coukos, George.

Lancet Oncol ; 21(9): e419-e430, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32888471

17.

TIL Therapy Entering the Mainstream.

Coukos, George.

N Engl J Med ; 387(23): 2185-2186, 2022 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-36477036

18.

Multielemental Analysis of Low-Volume Samples Reveals Cancer-Specific Profile in Serum and Sorted Immune Cells.

Konz, Tobias; Monnard, Caroline; Restrepo, Marcela Rincon; Laval, Julie; Sizzano, Federico; Girotra, Mukul; Dammone, Gabriele; Palini, Alessio; Coukos, George; Rezzi, Serge; Godin, Jean-Philippe; Vannini, Nicola.

Anal Chem ; 92(13): 8750-8758, 2020 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-32460479

19.

Modulation of the antitumor immune response by complement.

Markiewski, Maciej M; DeAngelis, Robert A; Benencia, Fabian; Ricklin-Lichtsteiner, Salome K; Koutoulaki, Anna; Gerard, Craig; Coukos, George; Lambris, John D.

Nat Immunol ; 9(11): 1225-35, 2008 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18820683

20.

Development of an optimized closed and semi-automatic protocol for Good Manufacturing Practice manufacturing of tumor-infiltrating lymphocytes in a hospital environment.

Gannon, Philippe O; Harari, Alexandre; Auger, Aymeric; Murgues, Clément; Zangiacomi, Vincent; Rubin, Olivier; Ellefsen Lavoie, Kim; Guillemot, Laurent; Navarro Rodrigo, Blanca; Nguyen-Ngoc, Tu; Rusakiewicz, Sylvie; Rossier, Laetitia; Boudousquié, Caroline; Baumgaertner, Petra; Zimmermann, Stefan; Trueb, Lionel; Iancu, Emanuela M; Sempoux, Christine; Demartines, Nicolas; Coukos, George; Kandalaft, Lana E.

Cytotherapy ; 22(12): 780-791, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33069566

BVS Violência e Saúde

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: