Detalhe da pesquisa
1.
Simeprevir plus sofosbuvir in patients with chronic hepatitis C virus genotype 1 infection and cirrhosis: A phase 3 study (OPTIMIST-2).
Hepatology
; 64(2): 360-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704148
2.
Simeprevir plus sofosbuvir (12 and 8 weeks) in hepatitis C virus genotype 1-infected patients without cirrhosis: OPTIMIST-1, a phase 3, randomized study.
Hepatology
; 64(2): 370-80, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26799692
3.
Effects of once-daily darunavir/ritonavir versus atazanavir/ritonavir on insulin sensitivity in HIV-infected persons over 48 weeks: results of an exploratory substudy of METABOLIK, a phase 4, randomized trial.
HIV Clin Trials
; 17(2): 72-7, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26917112
4.
Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial.
Lancet
; 384(9941): 414-26, 2014 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24907224
5.
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial.
Lancet
; 384(9941): 403-13, 2014 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24907225
6.
Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial.
Gastroenterology
; 146(7): 1669-79.e3, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24602923
7.
Simeprevir (TMC435) with pegylated interferon/ribavirin in patients coinfected with HCV genotype 1 and HIV-1: a phase 3 study.
Clin Infect Dis
; 59(11): 1579-87, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25192745
8.
Phase 1 Trial of the Safety, Pharmacokinetics, and Antiviral Activity of EDP-514 in Untreated Viremic Chronic Hepatitis B Patients.
Clin Mol Hepatol
; 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38528825
9.
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B.
Antivir Ther
; 27(6): 13596535221127848, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36382358
10.
Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.
J Med Chem
; 57(5): 1673-93, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446688
11.
Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.
PLoS One
; 9(3): e90485, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24603872
12.
Virological analysis of once-daily and twice-daily darunavir/ritonavir in the ODIN trial of treatment-experienced patients.
Antivir Ther
; 18(3): 289-300, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23558157
13.
Pharmacokinetics and Pharmacodynamics of Darunavir and Etravirine in HIV-1-Infected, Treatment-Experienced Patients in the Gender, Race, and Clinical Experience (GRACE) Trial.
AIDS Res Treat
; 2012: 186987, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22536495
14.
Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks.
AIDS Res Hum Retroviruses
; 28(10): 1184-95, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352336
15.
Pharmacoeconomics of darunavir.
Expert Rev Pharmacoecon Outcomes Res
; 11(1): 27-39, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21351854
16.
Effects of darunavir/ritonavir-based therapy on metabolic and anthropometric parameters in women and men over 48 weeks.
AIDS Patient Care STDS
; 25(6): 333-40, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21612545
17.
Darunavir outcomes study: comparative effectiveness of virologic suppression, regimen durability, and discontinuation reasons for three-class experienced patients at 48 weeks.
AIDS Res Hum Retroviruses
; 26(12): 1279-85, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20961276
18.
A case of Strongyloides stercoralis and mesenteric tuberculous infection with acute abdominal pain in an HIV-positive patient.
Scand J Infect Dis
; 34(9): 696-7, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12374368