Pesquisa | BVS Violência e Saúde

1.

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Chen, Wei-Ting; Lu, Ashley; Craessaerts, Katleen; Pavie, Benjamin; Sala Frigerio, Carlo; Corthout, Nikky; Qian, Xiaoyan; Laláková, Jana; Kühnemund, Malte; Voytyuk, Iryna; Wolfs, Leen; Mancuso, Renzo; Salta, Evgenia; Balusu, Sriram; Snellinx, An; Munck, Sebastian; Jurek, Aleksandra; Fernandez Navarro, Jose; Saido, Takaomi C; Huitinga, Inge; Lundeberg, Joakim; Fiers, Mark; De Strooper, Bart.

Cell ; 182(4): 976-991.e19, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32702314

2.

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Pasciuto, Emanuela; Burton, Oliver T; Roca, Carlos P; Lagou, Vasiliki; Rajan, Wenson D; Theys, Tom; Mancuso, Renzo; Tito, Raul Y; Kouser, Lubna; Callaerts-Vegh, Zsuzsanna; de la Fuente, Alerie G; Prezzemolo, Teresa; Mascali, Loriana G; Brajic, Aleksandra; Whyte, Carly E; Yshii, Lidia; Martinez-Muriana, Anna; Naughton, Michelle; Young, Andrew; Moudra, Alena; Lemaitre, Pierre; Poovathingal, Suresh; Raes, Jeroen; De Strooper, Bart; Fitzgerald, Denise C; Dooley, James; Liston, Adrian.

Cell ; 182(3): 625-640.e24, 2020 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-32702313

3.

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.

Yshii, Lidia; Pasciuto, Emanuela; Bielefeld, Pascal; Mascali, Loriana; Lemaitre, Pierre; Marino, Marika; Dooley, James; Kouser, Lubna; Verschoren, Stijn; Lagou, Vasiliki; Kemps, Hannelore; Gervois, Pascal; de Boer, Antina; Burton, Oliver T; Wahis, Jérôme; Verhaert, Jens; Tareen, Samar H K; Roca, Carlos P; Singh, Kailash; Whyte, Carly E; Kerstens, Axelle; Callaerts-Vegh, Zsuzsanna; Poovathingal, Suresh; Prezzemolo, Teresa; Wierda, Keimpe; Dashwood, Amy; Xie, Junhua; Van Wonterghem, Elien; Creemers, Eline; Aloulou, Meryem; Gsell, Willy; Abiega, Oihane; Munck, Sebastian; Vandenbroucke, Roosmarijn E; Bronckaers, Annelies; Lemmens, Robin; De Strooper, Bart; Van Den Bosch, Ludo; Himmelreich, Uwe; Fitzsimons, Carlos P; Holt, Matthew G; Liston, Adrian.

Nat Immunol ; 23(6): 878-891, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35618831

4.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper, Sebastiaan; Verheijden, Simon; Aguilera-Lizarraga, Javier; Viola, Maria Francesca; Boesmans, Werend; Stakenborg, Nathalie; Voytyuk, Iryna; Schmidt, Inga; Boeckx, Bram; Dierckx de Casterlé, Isabelle; Baekelandt, Veerle; Gonzalez Dominguez, Erika; Mack, Matthias; Depoortere, Inge; De Strooper, Bart; Sprangers, Ben; Himmelreich, Uwe; Soenen, Stefaan; Guilliams, Martin; Vanden Berghe, Pieter; Jones, Elizabeth; Lambrechts, Diether; Boeckxstaens, Guy.

Cell ; 175(2): 400-415.e13, 2018 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-30173915

5.

Alzheimer's-Causing Mutations Shift Aß Length by Destabilizing Î³-Secretase-Aßn Interactions.

Szaruga, Maria; Munteanu, Bogdan; Lismont, Sam; Veugelen, Sarah; Horré, Katrien; Mercken, Marc; Saido, Takaomi C; Ryan, Natalie S; De Vos, Tatjana; Savvides, Savvas N; Gallardo, Rodrigo; Schymkowitz, Joost; Rousseau, Frederic; Fox, Nick C; Hopf, Carsten; De Strooper, Bart; Chávez-Gutiérrez, Lucía.

Cell ; 170(3): 443-456.e14, 2017 Jul 27.

Artigo em Inglês | MEDLINE | ID: mdl-28753424

6.

The Cellular Phase of Alzheimer's Disease.

De Strooper, Bart; Karran, Eric.

Cell ; 164(4): 603-15, 2016 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-26871627

7.

Alzheimer's-causing mutations shift Aß length by destabilizing Î³-secretase-Aßn interactions.

Szaruga, Maria; Munteanu, Bogdan; Lismont, Sam; Veugelen, Sarah; Horré, Katrien; Mercken, Marc; Saido, Takaomi C; Ryan, Natalie S; De Vos, Tatjana; Savvides, Savvas N; Gallardo, Rodrigo; Schymkowitz, Joost; Rousseau, Frederic; Fox, Nick C; Hopf, Carsten; De Strooper, Bart; Chávez-Gutiérrez, Lucía.

Cell ; 184(8): 2257-2258, 2021 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-33861967

8.

Restricted Location of PSEN2/Î³-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool.

Sannerud, Ragna; Esselens, Cary; Ejsmont, Paulina; Mattera, Rafael; Rochin, Leila; Tharkeshwar, Arun Kumar; De Baets, Greet; De Wever, Veerle; Habets, Roger; Baert, Veerle; Vermeire, Wendy; Michiels, Christine; Groot, Arjan J; Wouters, Rosanne; Dillen, Katleen; Vints, Katlijn; Baatsen, Pieter; Munck, Sebastian; Derua, Rita; Waelkens, Etienne; Basi, Guriqbal S; Mercken, Mark; Vooijs, Marc; Bollen, Mathieu; Schymkowitz, Joost; Rousseau, Frederic; Bonifacino, Juan S; Van Niel, Guillaume; De Strooper, Bart; Annaert, Wim.

Cell ; 166(1): 193-208, 2016 Jun 30.

Artigo em Inglês | MEDLINE | ID: mdl-27293189

9.

The Î³-secretase substrate proteome and its role in cell signaling regulation.

Hou, Pengfei; Zielonka, Magdalena; Serneels, Lutgarde; Martinez-Muriana, Anna; Fattorelli, Nicola; Wolfs, Leen; Poovathingal, Suresh; T'Syen, Dries; Balusu, Sriram; Theys, Tom; Fiers, Mark; Mancuso, Renzo; Howden, Andrew J M; De Strooper, Bart.

Mol Cell ; 83(22): 4106-4122.e10, 2023 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-37977120

10.

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Hammad, Hamida; Vanderkerken, Matthias; Pouliot, Philippe; Deswarte, Kim; Toussaint, Wendy; Vergote, Karl; Vandersarren, Lana; Janssens, Sophie; Ramou, Ioanna; Savvides, Savvas N; Haigh, Jody J; Hendriks, Rudi; Kopf, Manfred; Craessaerts, Katleen; de Strooper, Bart; Kearney, John F; Conrad, Daniel H; Lambrecht, Bart N.

Nat Immunol ; 18(3): 313-320, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-28068307

11.

Lessons from a failed Î³-secretase Alzheimer trial.

De Strooper, Bart.

Cell ; 159(4): 721-6, 2014 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-25417150

12.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper, Sebastiaan; Verheijden, Simon; Aguilera-Lizarraga, Javier; Viola, Maria Francesca; Boesmans, Werend; Stakenborg, Nathalie; Voytyuk, Iryna; Schmidt, Inga; Boeckx, Bram; Dierckx de Casterlé, Isabelle; Baekelandt, Veerle; Gonzalez Dominguez, Erika; Mack, Matthias; Depoortere, Inge; De Strooper, Bart; Sprangers, Ben; Himmelreich, Uwe; Soenen, Stefaan; Guilliams, Martin; Vanden Berghe, Pieter; Jones, Elizabeth; Lambrechts, Diether; Boeckxstaens, Guy.

Cell ; 176(3): 676, 2019 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-30682373

13.

New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of Î³-secretases.

De Strooper, Bart; Karran, Eric.

EMBO J ; 43(6): 887-903, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38396302

14.

Do we still need animals? Surveying the role of animal-free models in Alzheimer's and Parkinson's disease research.

Aerts, Liesbeth; Miccoli, Beatrice; Delahanty, Aaron; Witters, Hilda; Verstraelen, Sandra; De Strooper, Bart; Braeken, Dries; Verstreken, Patrik.

EMBO J ; 41(6): e110002, 2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-35199384

15.

LifeTime and improving European healthcare through cell-based interceptive medicine.

Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; De Strooper, Bart; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A; Krabbe, Grietje; Lichter, Peter; Linnarsson, Sten; Marine, Jean-Christophe; Marioni, John C; Marti-Renom, Marc A; Netea, Mihai G; Nickel, Dörthe; Nollmann, Marcelo; Novak, Halina R; Parkinson, Helen; Piccolo, Stefano; Pinheiro, Inês; Pombo, Ana; Popp, Christian; Reik, Wolf; Roman-Roman, Sergio; Rosenstiel, Philip; Schultze, Joachim L; Stegle, Oliver; Tanay, Amos; Testa, Giuseppe; Thanos, Dimitris; Theis, Fabian J; Torres-Padilla, Maria-Elena; Valencia, Alfonso; Vallot, Céline; van Oudenaarden, Alexander; Vidal, Marie; Voet, Thierry.

Nature ; 587(7834): 377-386, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32894860

16.

Functional and topological analysis of PSENEN, the fourth subunit of the Î³-secretase complex.

Serneels, Lutgarde; Bammens, Leen; Zwijsen, An; Tolia, Alexandra; Chávez-Gutiérrez, Lucía; De Strooper, Bart.

J Biol Chem ; 300(1): 105533, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38072061

17.

Alzheimer's disease neurons fail the acid test.

Annaert, Wim; De Strooper, Bart.

Cell ; 141(7): 1112-4, 2010 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-20602994

18.

Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.

Erkert, Lena; Gamez-Belmonte, Reyes; Kabisch, Melanie; Schödel, Lena; Patankar, Jay V; Gonzalez-Acera, Miguel; Mahapatro, Mousumi; Bao, Li-Li; Plattner, Christina; Kühl, Anja A; Shen, Jie; Serneels, Lutgarde; De Strooper, Bart; Neurath, Markus F; Wirtz, Stefan; Becker, Christoph.

Gut ; 2024 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-38684238

19.

Selective inhibitors of the PSEN1-gamma-secretase complex.

Serneels, Lutgarde; Narlawar, Rajeshwar; Perez-Benito, Laura; Municoy, Marti; Guallar, Victor; T'Syen, Dries; Dewilde, Maarten; Bischoff, François; Fraiponts, Erwin; Tresadern, Gary; Roevens, Peter W M; Gijsen, Harrie J M; De Strooper, Bart.

J Biol Chem ; 299(6): 104794, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37164155

20.

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.

Sala Frigerio, Carlo; De Strooper, Bart.

Annu Rev Neurosci ; 39: 57-79, 2016 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-27050320

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

Alzheimer's-Causing Mutations Shift Aß Length by Destabilizing Î³-Secretase-Aßn Interactions.

The Cellular Phase of Alzheimer's Disease.

Alzheimer's-causing mutations shift Aß length by destabilizing Î³-secretase-Aßn interactions.

Restricted Location of PSEN2/Î³-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool.

The Î³-secretase substrate proteome and its role in cell signaling regulation.

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Lessons from a failed Î³-secretase Alzheimer trial.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of Î³-secretases.

Do we still need animals? Surveying the role of animal-free models in Alzheimer's and Parkinson's disease research.

LifeTime and improving European healthcare through cell-based interceptive medicine.

Functional and topological analysis of PSENEN, the fourth subunit of the Î³-secretase complex.

Alzheimer's disease neurons fail the acid test.

Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.

Selective inhibitors of the PSEN1-gamma-secretase complex.

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.