RESUMO
HLA-A*02:374 differs from HLA-A*02:01:01 by one amino acid change at codon 112 where G is replaced by V.
Assuntos
Alelos , Antígenos HLA-A/genética , Substituição de Aminoácidos , Sequência de Bases , Éxons , Humanos , Dados de Sequência Molecular , Alinhamento de SequênciaRESUMO
The newly detected HLA-B*51:141 is distinguished from HLA-B*51:08 by a single-nucleotide exchange at codon 30 where D is replaced by Y.
Assuntos
Alelos , Antígenos HLA-B/genética , Códon , Éxons , Humanos , Dados de Sequência Molecular , Polimorfismo de Nucleotídeo ÚnicoRESUMO
Description of a new non-human primate major histocompatibility complex (MHC)-B (Patr-B) allele.
Assuntos
Alelos , Teste de Histocompatibilidade , Pan troglodytes/genética , Substituição de Aminoácidos , Animais , Sequência de Bases , Clonagem Molecular , Códon , Sequência Consenso , DNA/genética , DNA/isolamento & purificação , Bases de Dados Factuais , Éxons , Dados de Sequência Molecular , Pan troglodytes/imunologia , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Serina/metabolismoRESUMO
This investigation was focused on the contribution of individual human leukocyte antigen (HLA)-DR and -DQ alleles to the human hepatitis C virus (HCV)(+) non-Hodgkin's lymphoma (NHL), with and without mixed cryoglobulinemia (MC), to study whether individual HLA class II alleles are expressed preferentially or equally in human HCV-specific NHL. For this purpose, peripheral blood mononuclear cells were obtained from two groups of patients with HCV(+) NHL and with or without MC (70 and 71 cases, respectively), and from 4575 blood donors. Eighty-three subjects with HCV infection only, and 118 patients with MC, only without lymphoma, were added as additional control groups. Individual HLA-DR and -DQ alleles were determined using high-resolution sequence-based typing and then data were collected by considering the HLA-DRB1 and DQB1 supertypes on the basis of common structural and functional features, proposed by in silico Bioinformatic studies. From the data, it is evidenced that the DR5-DQ3 HLA combination was strongly associated with the HCV (+) MC (+) NHL group of patients compared with bone marrow donor population (PAssuntos
Crioglobulinemia/genética
, Crioglobulinemia/virologia
, Hepacivirus/genética
, Antígenos de Histocompatibilidade Classe II/genética
, Linfoma não Hodgkin/genética
, Alelos
, Crioglobulinemia/etiologia
, Antígenos HLA-DQ/genética
, Antígenos HLA-DR/genética
, Cadeias HLA-DRB1
, Humanos
, Linfoma não Hodgkin/complicações
, Risco
RESUMO
A novel human leukocyte antigen (HLA)-A*680106 antigen was identified in two Italian individuals by polymerase chain reaction sequencing-based typing.
Assuntos
Alelos , Doença Celíaca/genética , Antígenos HLA-A/genética , Adulto , Sequência de Bases , Feminino , Predisposição Genética para Doença , Humanos , Itália , Dados de Sequência Molecular , Alinhamento de SequênciaRESUMO
Sequence-based typing strategy is used to identify polymorphism of Patr-DRB1. Two new Patr-DRB1 are described.
Assuntos
Antígenos de Histocompatibilidade Classe II/genética , Pan troglodytes/genética , Alelos , Animais , Sequência de Bases , Antígenos HLA-DR/genética , Cadeias HLA-DRB1 , Humanos , Dados de Sequência Molecular , Alinhamento de SequênciaRESUMO
Two new Patr-A, five new Patr-B and three new Patr-C alleles from Pan troglodytes are described.