1.
J Med Chem
; 58(23): 9345-53, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26561979
RESUMO
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article documents the discovery and optimization of a selective small molecule inhibitor of DGAT2 as well as pharmacological proof of biology in a mouse model of triglyceride production.