Synchronous Primary Gallbladder and Colon Adenocarcinoma: A Case Report and Systematic Literature Review.

Synchronous primary malignancies, defined as two or more primary malignancies diagnosed simultaneously or within six months, are uncommon and present unique diagnostic and therapeutic challenges. Synchronous primary adenocarcinoma of the gallbladder and colon is particularly rare. We report a case of a 48-year-old female presenting with persistent right upper abdominal pain. Laboratory tests and imaging studies initially suggested xanthogranulomatous cholecystitis. However, subsequent laparoscopic cholecystectomy and pathological examination revealed a moderately differentiated adenocarcinoma of the gallbladder (pT2bN1M0). Further staging with CT and PET-CT scans identified a suspicious mass in the transverse colon, confirmed by colonoscopy and surgical resection as well-differentiated adenocarcinoma of the transverse colon (pT3N0M0). Immunohistochemistry and genetic profiling of both tumors indicated distinct primary origins without loss of mismatch repair (MMR) protein expression. The patient underwent additional liver resection, lymph node dissection, and right extended hemicolectomy. She is currently undergoing further staging and awaiting chemotherapy. A review of English-language literature revealed eight reported cases of synchronous primary gallbladder and colorectal cancer and a total of 13 with synchronous primary malignancy of other organs. Such cases are rare and diagnostically complex cases. Common factors contributing to multiple primary malignancies (MPM) include genetic predispositions, previous cancer treatments, and lifestyle factors such as smoking and alcohol consumption. This case underscores the importance of thorough investigation and prompt treatment in patients suspected of having MPM. Advances in diagnostic imaging and molecular profiling are crucial for early detection and tailored therapeutic strategies. Standardized guidelines for managing synchronous cancers are needed to improve patient outcomes.

Femoral Hernia Containing a Strangulated Appendix: A Hybrid Approach.

We present an intriguing case of an incarcerated femoral hernia containing an inflamed appendix inside the sac, also known as a De Garengeot hernia. This type of hernia is a rare occurrence that was first described in 1731 by the French surgeon René-Jacque Croissant de Garengeot. A 64-year-old woman presented to the emergency department with a painful mass in the right groin region. Following a computed tomography (CT) scan of the abdomen and pelvis to evaluate the mass, the diagnosis of a femoral hernia containing a strangulated appendix was established. Subsequently, a hybrid surgical approach was utilized, consisting of an open hernia repair and a laparoscopic appendectomy.

Obturator Hernia in a 71-Year-Old Patient: A Diagnostic Challenge.

An obturator hernia is a relatively rare form of pelvic hernia, wherein abdominal organs protrude through an opening in the pelvis known as the obturator foramen. The majority of patients with this condition present to the emergency room with symptoms of bowel obstruction. Due to the non-specific nature of these symptoms, making a preoperative diagnosis of obturator hernia can be challenging. Any delay in the diagnosis and treatment of this condition can lead to a significant risk of mortality. In this report, we present the case of a 71-year-old patient who presented to the emergency department complaining of lower abdominal pain and nausea. An abdominal X-ray revealed bowel dilation, and based on the patient's symptoms, a diagnosis of bowel obstruction was suspected. A CT scan of the abdomen and pelvis was performed to investigate the reason for bowel dilation, and the existence of an obturator hernia was confirmed.

Right-Sided Diverticulitis: A Rare Cause of Right-Sided Abdominal Pain.

Acute diverticulitis is a particularly common medical entity, and its frequency increases with age. The most commonly affected part of the large intestine is the sigmoid colon, while right-sided diverticulitis is very rare. Here, we report the case of a 59-year-old man who presented to the emergency department due to acute right lower quadrant abdominal pain. The patient was diagnosed with a computed tomography scan of the abdomen with intravenous contrast with right-sided diverticulitis. The patient's treatment included hydration and intravenous antibiotics (ciprofloxacin and metronidazole). After three days of hospitalization, the patient was discharged from the hospital in stable condition and without signs of inflammation. This case report demonstrates the importance of including right-sided diverticulitis in the differential diagnosis of acute right lower quadrant abdominal pain, as in most cases patients are treated conservatively without the need for surgical intervention.

A Rare Case of Spontaneous Pneumothorax Recurrence 30 Years After Surgery in a Patient with Birt-Hogg-Dube Syndrome: Case Presentation and Short Review of the Literature.

Background: Birt-Hogg-Dube syndrome (BHDS), also known as Hornstein-Knickenberg syndrome is a rare, autosomal dominant genetic disorder characterized by a triad of clinical manifestations: skin fibrofolliculomas, renal tumors, and multiple pulmonary cysts. The exact incidence of BHDS syndrome is unknown. This hereditary syndrome is caused by mutations in the folliculin (FLCN) gene, located on chromosome 17p11.2, which encodes the folliculin protein. Objective: This case report aims to highlight the importance of increased vigilance and long-term follow-up in BHDS patients, even decades after surgical intervention, to detect and manage potential pulmonary complications effectively. Case presentation: We present a unique case of spontaneous pneumothorax recurrence in a 63-year-old patient with a history of Birt-Hogg-Dube syndrome. The patient had undergone surgical treatment for pneumothorax 30 years ago and remained asymptomatic until presenting to our clinic with acute dyspnea and a dry cough. A recurrent pneumothorax was diagnosed and treated with a chest tube. Further chest imaging revealed extensive ground-glass opacities and cysts in both lungs. The patient was diagnosed with active pneumonia. A conservative approach was adopted due to the pneumonia diagnosis, and the patient showed a successful recovery without pneumothorax recurrence. Conclusion: This case highlights the importance of long-term follow-up in patients with Birt-Hogg-Dube syndrome and previous pneumothorax episodes.