Detalhe da pesquisa
1.
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.
Proc Natl Acad Sci U S A
; 119(29): e2200553119, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858317
2.
Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates.
Nat Chem Biol
; 18(3): 332-341, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35210619
3.
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
Angew Chem Int Ed Engl
; 62(40): e202309306, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37582679
4.
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
Angew Chem Int Ed Engl
; 61(38): e202207974, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864061
5.
Directed evolution of a remarkably efficient Kdnase from a bacterial neuraminidase.
Glycobiology
; 30(5): 325-333, 2020 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31804700
6.
A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.
Angew Chem Int Ed Engl
; 59(24): 9601-9609, 2020 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32092778
7.
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo.
Curr Opin Chem Biol
; 77: 102403, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37856901
8.
A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.
ACS Chem Biol
; 18(8): 1730-1737, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531094
9.
Targeting neuronal lysosomal dysfunction caused by ß-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Nat Commun
; 14(1): 2057, 2023 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37045813
10.
Selective Fluorogenic ß-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates.
ACS Chem Biol
; 15(4): 824-829, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32109051