Pesquisa | BVS Violência e Saúde

1.

Redirected T Cell Cytotoxicity in Cancer Therapy.

Clynes, Raphael A; Desjarlais, John R.

Annu Rev Med ; 70: 437-450, 2019 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-30379598

2.

A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats.

Moore, Gregory L; Bernett, Matthew J; Rashid, Rumana; Pong, Erik W; Nguyen, Duc-Hanh T; Jacinto, Jonathan; Eivazi, Araz; Nisthal, Alex; Diaz, Juan E; Chu, Seung Y; Muchhal, Umesh S; Desjarlais, John R.

Methods ; 154: 38-50, 2019 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-30366098

3.

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.

Tai, Yu-Tzu; Horton, Holly M; Kong, Sun-Young; Pong, Erik; Chen, Hsing; Cemerski, Saso; Bernett, Matthew J; Nguyen, Duc-Hanh T; Karki, Sher; Chu, Seung Y; Lazar, Greg A; Munshi, Nikhil C; Desjarlais, John R; Anderson, Kenneth C; Muchhal, Umesh S.

Blood ; 119(9): 2074-82, 2012 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-22246035

4.

AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.

Nolan-Stevaux, Olivier; Li, Cong; Liang, Lingming; Zhan, Jinghui; Estrada, Juan; Osgood, Tao; Li, Fei; Zhang, Hanzhi; Case, Ryan; Murawsky, Christopher M; Estes, Bram; Moore, Gregory L; Bernett, Matthew J; Muchhal, Umesh; Desjarlais, John R; Staley, Binnaz K; Stevens, Jennitte; Cooke, Keegan S; Aeffner, Famke; Thomas, Oliver; Stieglmaier, Julia; Lee, Jae-Lyun; Coxon, Angela; Bailis, Julie M.

Cancer Discov ; 14(1): 90-103, 2024 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-37861452

5.

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.

Yadav, Rajbharan; Schubbert, Suzanne; Holder, Patrick G; Chiang, Eugene Y; Kiabi, Nargess; Bogaert, Liz; Leung, Irene; Rashid, Rumana; Avery, Kendra N; Bonzon, Christine; Desjarlais, John R; Sanjabi, Shomyseh; Sharma, Amy; Lepherd, Michelle; Shelton, Amy; Chan, Pam; Liu, Yanqiu; Joslyn, Louis; Hosseini, Iraj; Stefanich, Eric G; Kamath, Amrita V; Bernett, Matthew J; Shivva, Vittal.

Front Pharmacol ; 15: 1380000, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38887559

6.

Antibody-mediated coengagement of FcÎ³RIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.

Horton, Holly M; Chu, Seung Y; Ortiz, Elizabeth C; Pong, Erik; Cemerski, Saso; Leung, Irene W L; Jacob, Noam; Zalevsky, Jonathan; Desjarlais, John R; Stohl, William; Szymkowski, David E.

J Immunol ; 186(7): 4223-33, 2011 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-21357255

7.

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcÎ³RIIb with Fc-engineered antibody.

Chu, Seung Y; Horton, Holly M; Pong, Erik; Leung, Irene W L; Chen, Hsing; Nguyen, Duc-Hanh; Bautista, Cristina; Muchhal, Umesh S; Bernett, Matthew J; Moore, Gregory L; Szymkowski, David E; Desjarlais, John R.

J Allergy Clin Immunol ; 129(4): 1102-15, 2012 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-22257644

8.

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies.

Horton, Holly M; Bernett, Matthew J; Peipp, Matthias; Pong, Erik; Karki, Sher; Chu, Seung Y; Richards, John O; Chen, Hsing; Repp, Roland; Desjarlais, John R; Zhukovsky, Eugene A.

Blood ; 116(16): 3004-12, 2010 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-20616215

9.

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody.

Awan, Farrukh T; Lapalombella, Rosa; Trotta, Rossana; Butchar, Jonathan P; Yu, Bo; Benson, Don M; Roda, Julie M; Cheney, Carolyn; Mo, Xiaokui; Lehman, Amy; Jones, Jeffrey; Flynn, Joseph; Jarjoura, David; Desjarlais, John R; Tridandapani, Susheela; Caligiuri, Michael A; Muthusamy, Natarajan; Byrd, John C.

Blood ; 115(6): 1204-13, 2010 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-19965644

10.

Modulation of antibody effector function.

Desjarlais, John R; Lazar, Greg A.

Exp Cell Res ; 317(9): 1278-85, 2011 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-21459085

11.

The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates.

Zalevsky, Jonathan; Leung, Irene W L; Karki, Sher; Chu, Seung Y; Zhukovsky, Eugene A; Desjarlais, John R; Carmichael, David F; Lawrence, Chris E.

Blood ; 113(16): 3735-43, 2009 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-19109559

12.

Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022.

Atyeo, Caroline; Slein, Matthew D; Fischinger, Stephanie; Burke, John; Schäfer, Alexandra; Leist, Sarah R; Kuzmina, Natalia A; Mire, Chad; Honko, Anna; Johnson, Rebecca; Storm, Nadia; Bernett, Matthew; Tong, Pei; Zuo, Teng; Lin, Junrui; Zuiani, Adam; Linde, Caitlyn; Suscovich, Todd; Wesemann, Duane R; Griffiths, Anthony; Desjarlais, John R; Juelg, Boris D; Goudsmit, Jaap; Bukreyev, Alexander; Baric, Ralph; Alter, Galit.

JCI Insight ; 6(1)2021 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-33427208

13.

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.

Chu, Seung Y; Vostiar, Igor; Karki, Sher; Moore, Gregory L; Lazar, Greg A; Pong, Erik; Joyce, Patrick F; Szymkowski, David E; Desjarlais, John R.

Mol Immunol ; 45(15): 3926-33, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18691763

14.

Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells.

Richards, John O; Karki, Sher; Lazar, Greg A; Chen, Hsing; Dang, Wei; Desjarlais, John R.

Mol Cancer Ther ; 7(8): 2517-27, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18723496

15.

Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release.

Zuch de Zafra, Christina L; Fajardo, Flordeliza; Zhong, Wendy; Bernett, Matthew J; Muchhal, Umesh S; Moore, Gregory L; Stevens, Jennitte; Case, Ryan; Pearson, Joshua T; Liu, Siyuan; McElroy, Patricia L; Canon, Jude; Desjarlais, John R; Coxon, Angela; Balazs, Mercedesz; Nolan-Stevaux, Olivier.

Clin Cancer Res ; 25(13): 3921-3933, 2019 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-30918018

16.

A molecular immunology approach to antibody humanization and functional optimization.

Lazar, Greg A; Desjarlais, John R; Jacinto, Jonathan; Karki, Sher; Hammond, Philip W.

Mol Immunol ; 44(8): 1986-98, 2007 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-17079018

17.

Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective.

Desjarlais, John R; Lazar, Greg A; Zhukovsky, Eugene A; Chu, Seung Y.

Drug Discov Today ; 12(21-22): 898-910, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17993407

18.

Designing proteins for therapeutic applications.

Lazar, Greg A; Marshall, Shannon A; Plecs, Joseph J; Mayo, Stephen L; Desjarlais, John R.

Curr Opin Struct Biol ; 13(4): 513-8, 2003 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-12948782

19.

A de novo redesign of the WW domain.

Kraemer-Pecore, Christina M; Lecomte, Juliette T J; Desjarlais, John R.

Protein Sci ; 12(10): 2194-205, 2003 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-14500877

20.

Thoroughly sampling sequence space: large-scale protein design of structural ensembles.

Larson, Stefan M; England, Jeremy L; Desjarlais, John R; Pande, Vijay S.

Protein Sci ; 11(12): 2804-13, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-12441379

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