Detalhe da pesquisa
1.
Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11ß-HSD1.
Bioorg Med Chem Lett
; 73: 128884, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35835377
2.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35537608
3.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345620
4.
Effects of Epacadostat on Brain Extracellular Fluid Concentrations of Serotonin-an Intracerebral Microdialysis Study in Sprague-Dawley Rats.
Drug Metab Dispos
; 47(7): 710-714, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010933
5.
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
J Pharmacol Exp Ther
; 364(1): 120-130, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127109
6.
In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions.
Drug Metab Dispos
; 45(6): 612-623, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283500
7.
Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.
Drug Metab Dispos
; 44(10): 1668-74, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27457784
8.
Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110.
Drug Metab Dispos
; 43(4): 485-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605813
9.
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab Dispos
; 42(10): 1656-62, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25063672
10.
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J Med Chem
; 67(4): 3112-3126, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325398
11.
Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
ACS Med Chem Lett
; 14(1): 5-10, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655125
12.
Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
ACS Med Chem Lett
; 14(1): 116-122, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655134
13.
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
ACS Med Chem Lett
; 14(3): 312-318, 2023 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923909
14.
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors.
ACS Med Chem Lett
; 13(11): 1797-1804, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385925
15.
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
ACS Med Chem Lett
; 13(7): 1159-1164, 2022 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35859885
16.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Cancer Discov
; 12(6): 1482-1499, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35254416
17.
Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist.
Bioorg Med Chem Lett
; 21(5): 1442-6, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295478
18.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34269576
19.
Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.
Drug Metab Dispos
; 38(8): 1277-85, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20421447
20.
Metabolism, excretion, and pharmacokinetics of [14C]INCB018424, a selective Janus tyrosine kinase 1/2 inhibitor, in humans.
Drug Metab Dispos
; 38(11): 2023-31, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20699411