Detalhe da pesquisa
1.
Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension.
Acta Pharmacol Sin
; 44(1): 221-233, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-35676531
2.
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans.
Xenobiotica
; 53(2): 69-83, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36745485
3.
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes.
Acta Pharmacol Sin
; 43(3): 747-756, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34035488
4.
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia.
Bioorg Med Chem
; 37: 116109, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780813
5.
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified.
Acta Pharmacol Sin
; 42(2): 311-322, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860005
6.
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor.
Acta Pharmacol Sin
; 42(3): 482-490, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32581257
7.
Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta Pharmacol Sin
; 42(9): 1535-1546, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244163
8.
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer.
Acta Pharmacol Sin
; 41(10): 1366-1376, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32235864
9.
Author Correction: Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta Pharmacol Sin
; 44(12): 2549, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37532785
10.
Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier.
Acta Pharmacol Sin
; 36(12): 1520-7, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26567730
11.
A robust and validated LC-MS/MS method for the quantification of ramucirumab in rat and human serum using direct enzymatic digestion without immunoassay.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1234: 123991, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266611
12.
Development and validation of a LC-MS/MS method for quantitation of recombinant human growth hormone in rat plasma and application to a pharmacokinetic study.
J Pharm Biomed Anal
; 224: 115188, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469998
13.
Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats.
Cancer Chemother Pharmacol
; 90(6): 499-510, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36283983
14.
[Setup and Microbial Community Analysis of ANAMMOX System for Landfill Leachate Treatment Coupling Partial Nitrification-Denitrification Process].
Huan Jing Ke Xue
; 40(9): 4195-4201, 2019 Sep 08.
Artigo
em Zh
| MEDLINE | ID: mdl-31854885