Pesquisa | BVS Violência e Saúde

1.

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.

Wang, Kun; Sun, Qi; Zhong, Xiu; Zeng, Mengxue; Zeng, Huan; Shi, Xuyan; Li, Zilin; Wang, Yupeng; Zhao, Qiang; Shao, Feng; Ding, Jingjin.

Cell ; 180(5): 941-955.e20, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-32109412

2.

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy.

Xu, Yue; Zhou, Ping; Cheng, Sen; Lu, Qiuhe; Nowak, Kathrin; Hopp, Ann-Katrin; Li, Lin; Shi, Xuyan; Zhou, Zhiwei; Gao, Wenqing; Li, Da; He, Huabin; Liu, Xiaoyun; Ding, Jingjin; Hottiger, Michael O; Shao, Feng.

Cell ; 178(3): 552-566.e20, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31327526

3.

SnapShot: The Noncanonical Inflammasome.

Ding, Jingjin; Shao, Feng.

Cell ; 168(3): 544-544.e1, 2017 01 26.

Artigo em Inglês | MEDLINE | ID: mdl-28129545

4.

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

Shi, Xuyan; Sun, Qichao; Hou, Yanjie; Zeng, Huan; Cao, Yong; Dong, Mengqiu; Ding, Jingjin; Shao, Feng.

Nature ; 624(7991): 442-450, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37993714

5.

Structural mechanisms for regulation of GSDMB pore-forming activity.

Zhong, Xiu; Zeng, Huan; Zhou, Zhiwei; Su, Ya; Cheng, Hang; Hou, Yanjie; She, Yang; Feng, Na; Wang, Jia; Shao, Feng; Ding, Jingjin.

Nature ; 616(7957): 598-605, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36991125

6.

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.

Li, Zilin; Liu, Wang; Fu, Jiaqi; Cheng, Sen; Xu, Yue; Wang, Zhiqiang; Liu, Xiaofan; Shi, Xuyan; Liu, Yaxin; Qi, Xiangbing; Liu, Xiaoyun; Ding, Jingjin; Shao, Feng.

Nature ; 599(7884): 290-295, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34671164

7.

Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector.

Ding, Jingjin; Pan, Xing; Du, Lijie; Yao, Qing; Xue, Juan; Yao, Hongwei; Wang, Da-Cheng; Li, Shan; Shao, Feng.

Mol Cell ; 74(5): 922-935.e6, 2019 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-30979585

8.

A bioorthogonal system reveals antitumour immune function of pyroptosis.

Wang, Qinyang; Wang, Yupeng; Ding, Jingjin; Wang, Chunhong; Zhou, Xuehan; Gao, Wenqing; Huang, Huanwei; Shao, Feng; Liu, Zhibo.

Nature ; 579(7799): 421-426, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32188939

9.

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.

Zhou, Ping; She, Yang; Dong, Na; Li, Peng; He, Huabin; Borio, Alessio; Wu, Qingcui; Lu, Shan; Ding, Xiaojun; Cao, Yong; Xu, Yue; Gao, Wenqing; Dong, Mengqiu; Ding, Jingjin; Wang, Da-Cheng; Zamyatina, Alla; Shao, Feng.

Nature ; 561(7721): 122-126, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30111836

10.

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

Wang, Yupeng; Gao, Wenqing; Shi, Xuyan; Ding, Jingjin; Liu, Wang; He, Huabin; Wang, Kun; Shao, Feng.

Nature ; 547(7661): 99-103, 2017 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-28459430

11.

Pore-forming activity and structural autoinhibition of the gasdermin family.

Ding, Jingjin; Wang, Kun; Liu, Wang; She, Yang; Sun, Qi; Shi, Jianjin; Sun, Hanzi; Wang, Da-Cheng; Shao, Feng.

Nature ; 535(7610): 111-6, 2016 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-27281216

12.

Inflammatory caspases are innate immune receptors for intracellular LPS.

Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng.

Nature ; 514(7521): 187-92, 2014 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-25119034

13.

Growing a gasdermin pore in membranes of pyroptotic cells.

Ding, Jingjin; Shao, Feng.

EMBO J ; 37(15)2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-29997177

14.

Erratum: Pore-forming activity and structural autoinhibition of the gasdermin family.

Ding, Jingjin; Wang, Kun; Liu, Wang; She, Yang; Sun, Qi; Shi, Jianjin; Sun, Hanzi; Wang, Da-Cheng; Shao, Feng.

Nature ; 540(7631): 150, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-27706141

15.

Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA.

Wang, Wei; Ding, Jingjin; Zhang, Ying; Hu, Yonglin; Wang, Da-Cheng.

Nucleic Acids Res ; 42(5): 3478-91, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24369431

16.

Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea.

Guo, Li; Ding, Jingjin; Guo, Rong; Hou, Yanjie; Wang, Da-Cheng; Huang, Li.

J Biol Chem ; 289(3): 1478-90, 2014 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-24307170

17.

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins.

Feng, Han; Ding, Jingjin; Zhu, Deyu; Liu, Xuehui; Xu, Xueyong; Zhang, Ying; Zang, Shanshan; Wang, Da-Cheng; Liu, Wei.

J Am Chem Soc ; 136(42): 14694-7, 2014 Oct 22.

Artigo em Inglês | MEDLINE | ID: mdl-25268575

18.

Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation.

Zeng, Mengxue; Wang, Kun; Wu, Qingcui; Ding, Jingjin; Xie, Dan; Qi, Xiangbing; Shao, Feng.

Protein Cell ; 2024 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-38676703

19.

Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms.

Li, Yueyue; Hou, Yanjie; Sun, Qi; Zeng, Huan; Meng, Fanyi; Tian, Xiang; He, Qun; Shao, Feng; Ding, Jingjin.

Science ; 384(6697): adm9190, 2024 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-38662913

20.

Structural insights into the Pseudomonas aeruginosa type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms.

Ding, Jingjin; Wang, Wei; Feng, Han; Zhang, Ying; Wang, Da-Cheng.

J Biol Chem ; 287(32): 26911-20, 2012 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-22700987

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