Pesquisa | BVS Violência e Saúde

1.

A glimpse at the glycoRNA world.

Disney, Matthew D.

Cell ; 184(12): 3080-3081, 2021 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-34115968

2.

Programming inactive RNA-binding small molecules into bioactive degraders.

Tong, Yuquan; Lee, Yeongju; Liu, Xiaohui; Childs-Disney, Jessica L; Suresh, Blessy M; Benhamou, Raphael I; Yang, Chunying; Li, Weimin; Costales, Matthew G; Haniff, Hafeez S; Sievers, Sonja; Abegg, Daniel; Wegner, Tristan; Paulisch, Tiffany O; Lekah, Elizabeth; Grefe, Maison; Crynen, Gogce; Van Meter, Montina; Wang, Tenghui; Gibaut, Quentin M R; Cleveland, John L; Adibekian, Alexander; Glorius, Frank; Waldmann, Herbert; Disney, Matthew D.

Nature ; 618(7963): 169-179, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37225982

3.

Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.

Tong, Yuquan; Zhang, Peiyuan; Yang, Xueyi; Liu, Xiaohui; Zhang, Jie; Grudniewska, Magda; Jung, Ikrak; Abegg, Daniel; Liu, Jun; Childs-Disney, Jessica L; Gibaut, Quentin M R; Haniff, Hafeez S; Adibekian, Alexander; Mouradian, M Maral; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 121(2): e2306682120, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38181056

4.

Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies.

Taghavi, Amirhossein; Baisden, Jared T; Childs-Disney, Jessica L; Yildirim, Ilyas; Disney, Matthew D.

Nucleic Acids Res ; 51(11): 5325-5340, 2023 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-37216594

5.

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor.

Benhamou, Raphael I; Suresh, Blessy M; Tong, Yuquan; Cochrane, Wesley G; Cavett, Valerie; Vezina-Dawod, Simon; Abegg, Daniel; Childs-Disney, Jessica L; Adibekian, Alexander; Paegel, Brian M; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 119(6)2022 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-35110406

6.

A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome.

Bush, Jessica A; Meyer, Samantha M; Fuerst, Rita; Tong, Yuquan; Li, Yue; Benhamou, Raphael I; Aikawa, Haruo; Zanon, Patrick R A; Gibaut, Quentin M R; Angelbello, Alicia J; Gendron, Tania F; Zhang, Yong-Jie; Petrucelli, Leonard; Heick Jensen, Torben; Childs-Disney, Jessica L; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 119(48): e2210532119, 2022 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-36409902

7.

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.

Haify, Saif N; Buijsen, Ronald A M; Verwegen, Lucas; Severijnen, Lies-Anne W F M; de Boer, Helen; Boumeester, Valerie; Monshouwer, Roos; Yang, Wang-Yong; Cameron, Michael D; Willemsen, Rob; Disney, Matthew D; Hukema, Renate K.

Hum Mol Genet ; 30(17): 1632-1648, 2021 08 12.

Artigo em Inglês | MEDLINE | ID: mdl-34077515

8.

A general fragment-based approach to identify and optimize bioactive ligands targeting RNA.

Suresh, Blessy M; Li, Weichao; Zhang, Peiyuan; Wang, Kye Won; Yildirim, Ilyas; Parker, Christopher G; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 117(52): 33197-33203, 2020 12 29.

Artigo em Inglês | MEDLINE | ID: mdl-33318191

9.

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.

Costales, Matthew G; Aikawa, Haruo; Li, Yue; Childs-Disney, Jessica L; Abegg, Daniel; Hoch, Dominic G; Pradeep Velagapudi, Sai; Nakai, Yoshio; Khan, Tanya; Wang, Kye Won; Yildirim, Ilyas; Adibekian, Alexander; Wang, Eric T; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 117(5): 2406-2411, 2020 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-31964809

10.

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.

Zhang, Peiyuan; Park, Hye-Jin; Zhang, Jie; Junn, Eunsung; Andrews, Ryan J; Velagapudi, Sai Pradeep; Abegg, Daniel; Vishnu, Kamalakannan; Costales, Matthew G; Childs-Disney, Jessica L; Adibekian, Alexander; Moss, Walter N; Mouradian, M Maral; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 117(3): 1457-1467, 2020 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-31900363

11.

Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells.

Suresh, Blessy M; Akahori, Yoshihiro; Taghavi, Amirhossein; Crynen, Gogce; Gibaut, Quentin M R; Li, Yue; Disney, Matthew D.

J Am Chem Soc ; 144(45): 20815-20824, 2022 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-36322830

12.

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.

Gibaut, Quentin M R; Akahori, Yoshihiro; Bush, Jessica A; Taghavi, Amirhossein; Tanaka, Toru; Aikawa, Haruo; Ryan, Lucas S; Paegel, Brian M; Disney, Matthew D.

J Am Chem Soc ; 144(48): 21972-21979, 2022 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-36399603

13.

DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).

Meyer, Samantha M; Tanaka, Toru; Zanon, Patrick R A; Baisden, Jared T; Abegg, Daniel; Yang, Xueyi; Akahori, Yoshihiro; Alshakarchi, Zainab; Cameron, Michael D; Adibekian, Alexander; Disney, Matthew D.

J Am Chem Soc ; 144(46): 21096-21102, 2022 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-36342850

14.

**Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA**.

Tong, Yuquan; Gibaut, Quentin M R; Rouse, Warren; Childs-Disney, Jessica L; Suresh, Blessy M; Abegg, Daniel; Choudhary, Shruti; Akahori, Yoshihiro; Adibekian, Alexander; Moss, Walter N; Disney, Matthew D.

J Am Chem Soc ; 144(26): 11620-11625, 2022 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-35737519

15.

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model.

Angelbello, Alicia J; Rzuczek, Suzanne G; Mckee, Kendra K; Chen, Jonathan L; Olafson, Hailey; Cameron, Michael D; Moss, Walter N; Wang, Eric T; Disney, Matthew D.

Proc Natl Acad Sci U S A ; 116(16): 7799-7804, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30926669

16.

Inhibiting Translation One Protein at a Time.

Disney, Matthew D.

Trends Biochem Sci ; 42(6): 412-413, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28522328

17.

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.

Zhang, Peiyuan; Liu, Xiaohui; Abegg, Daniel; Tanaka, Toru; Tong, Yuquan; Benhamou, Raphael I; Baisden, Jared; Crynen, Gogce; Meyer, Samantha M; Cameron, Michael D; Chatterjee, Arnab K; Adibekian, Alexander; Childs-Disney, Jessica L; Disney, Matthew D.

J Am Chem Soc ; 143(33): 13044-13055, 2021 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-34387474

18.

Small molecule recognition of disease-relevant RNA structures.

Meyer, Samantha M; Williams, Christopher C; Akahori, Yoshihiro; Tanaka, Toru; Aikawa, Haruo; Tong, Yuquan; Childs-Disney, Jessica L; Disney, Matthew D.

Chem Soc Rev ; 49(19): 7167-7199, 2020 Oct 05.

Artigo em Inglês | MEDLINE | ID: mdl-32975549

19.

Design of small molecules targeting RNA structure from sequence.

Ursu, Andrei; Childs-Disney, Jessica L; Andrews, Ryan J; O'Leary, Collin A; Meyer, Samantha M; Angelbello, Alicia J; Moss, Walter N; Disney, Matthew D.

Chem Soc Rev ; 49(20): 7252-7270, 2020 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-32935689

20.

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands.

Liu, Xiaohui; Haniff, Hafeez S; Childs-Disney, Jessica L; Shuster, Anton; Aikawa, Haruo; Adibekian, Alexander; Disney, Matthew D.

J Am Chem Soc ; 142(15): 6970-6982, 2020 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-32233464

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