Does A Low 6-Minute Walk Distance Predict Elevated Postoperative Troponin?

Our study of 100 major vascular and renal transplant patients evaluated the 6-minute walk test (6MWT) as an indicator of perioperative myocardial injury, using troponin as a marker. Using logistic regression and the area under the receiving operator characteristic curve, we compared the 6MWT to the Revised Cardiac Risk Index and metabolic equivalents. Only the 6MWT was associated with elevated postoperative troponins (95% CI, 0.98-0.99). However, the 6MWT area under the receiving operator characteristic curve (0.71 [95% CI, 0.57-0.85]) was not different from the Revised Cardiac Risk Index (P = .23) or metabolic equivalents (P = .14). The 6MWT may have a role in cardiac risk stratification in the perioperative setting.

Intraoperative High Tidal Volume Ventilation and Postoperative Acute Respiratory Distress Syndrome in Liver Transplant.

BACKGROUND: Mechanical ventilation plays an important role in perioperative management and patient outcomes. Although mechanical ventilation with high tidal volume (HTV) is injurious in patients in the intensive care unit, the effects of HTV ventilation in patients undergoing liver transplant (LT) has not been reported. The aim of this study was to determine if intraoperative HTV ventilation was associated with the development of acute respiratory distress syndrome (ARDS). METHODS: Patients undergoing LT between 2013 and 2018 at a tertiary medical center were reviewed. The tidal volume was recorded at 3 time points: after anesthesia induction, before liver reperfusion, and at the end of surgery. Patients were divided into 2 groups: HTV (>10 mL/kg predicted body weight [pBW]) and non-HTV (≤10 mL/kg pBW). The 2 groups were compared. Independent risk factors were identified by multivariable logistic models. RESULTS: Of 780 LT patients, 85 (10.9%) received HTV ventilation. Female sex and greater difference between actual body weight and pBW were independent risk factors for HTV ventilation. Patients who received HTV ventilation had a significantly higher incidence of ARDS (10.3% vs 3.9%; P = .01) than those who received non-HTV ventilation. CONCLUSIONS: In this retrospective study, we showed that HTV ventilation during LT was common and was associated with a higher incidence of ARDS. Therefore, tidal volume should be carefully selected during LT surgery. More studies using a prospective randomized controlled design are needed.

Ventilator Failure Following Cardiopulmonary Bypass: A Case Report.

We present 3 cardiothoracic surgery cases during which the Drager Perseus A500 anesthesia machine and the iNOmax Delivery System were used concurrently, resulting in ventilator failures while attempting to separate from cardiopulmonary bypass (CPB). The failure was found to be caused by the iNOmax Delivery System sampling line, where negative pressure on the Perseus A500 breathing circuit precipitated a ventilator failure when the machine was brought out of "standby mode." To our knowledge, there is no discussion of this interaction in the literature, and we find this to be an important issue for patient safety during cardiothoracic surgery.

Icodextrin causing glucose meter error and severe hypoglycemia after deceased donor renal transplant in a patient receiving continuous ambulatory peritoneal dialysis.

Hypoglycemia is a frequent problem encountered with diabetics and hospitalized patients. Although point-of-care glucose meters have revolutionized management, there are circumstances wherein glucose meter readings are inaccurate. One such example of glucose meter error occurred in a patient with end-stage renal disease receiving peritoneal dialysis who underwent renal transplantation. After surgery, the patient's laboratory testing reflected hypoglycemia, while point-of-care glucose meter testing indicated hyperglycemia. It is important to remember that the "gold standard" is the laboratory serum glucose test, and if a discrepancy from point-of-care results occurs, an investigation should be made to ascertain the reason.