Detalhe da pesquisa
1.
VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys.
J Lipid Res
; 65(2): 100497, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216056
2.
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.
Alzheimers Dement
; 20(2): 1421-1435, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37897797
3.
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.
Acta Neuropathol
; 143(1): 55-73, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34741635
4.
A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine.
Mov Disord
; 37(7): 1416-1424, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35426173
5.
Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders.
Brain
; 143(2): 407-429, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31738395
6.
Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
Mol Cell
; 50(2): 172-84, 2013 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23499007
7.
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.
J Neurosci
; 35(38): 13029-42, 2015 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26400934
8.
Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice.
Neurobiol Dis
; 82: 372-384, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26215784
9.
Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 2a study.
EBioMedicine
; 94: 104665, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37392597
10.
RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques.
Vaccines (Basel)
; 12(1)2023 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38250853
11.
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Behav Pharmacol
; 22(2): 91-100, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21301326
12.
Amyloid-ß and α-Synuclein Immunotherapy: From Experimental Studies to Clinical Trials.
Front Neurosci
; 15: 733857, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34539340
13.
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
Nat Commun
; 12(1): 847, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558503
14.
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.
Alzheimers Res Ther
; 12(1): 159, 2020 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33256825
15.
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
J Med Chem
; 63(3): 1068-1083, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31955578
16.
Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice.
Neurobiol Learn Mem
; 90(2): 426-33, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18602845
17.
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
Behav Brain Res
; 193(2): 174-82, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18572260
18.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
Nat Neurosci
; 5(5): 452-7, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11941374
19.
Correction: Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.
Alzheimers Res Ther
; 15(1): 18, 2023 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36681823
20.
Immunotherapy for Alzheimer's disease: will vaccination work?
Trends Mol Med
; 9(3): 85-7, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657428