Atlanto-occipital and lateral atlanto-axial joint pain patterns.

STUDY DESIGN: Five asymptomatic subjects underwent provocative injections of the lateral atlanto-axial and atlanto-occipital joints. OBJECTIVES: This study isolated and stimulated the lateral atlanto-axial and atlanto-occipital joints via fluoroscopically guided intra-articular injections to determine if they are potential pain generators. If they are pain generators, preliminary pain pattern maps will be constructed. SUMMARY OF BACKGROUND DATA: The cervical zygapophyseal joints (C2-3 to C6-7) are potential pain generators as demonstrated by referred pain induced via isolated intra-articular joint injections in normal subjects. Tentative referral patterns based on direct mechanical stimulation of the lateral atlanto-axial and atlanto-occipital joints have not been reported. METHODS: Five volunteers without histories of upper cervical pain underwent two joint injections each. In all five subjects, the left atlanto-occipital and right lateral atlanto-axial joints were stimulated via injection of contrast medium causing distension of the joint capsule. RESULTS: Referred pain was produced with all ten injections. The lateral atlanto-axial injections resulted in consistent referral patterns, whereas the atlanto-occipital referral patterns varied significantly. A tentative composite diagram of the experimentally induced pain was created for each joint. CONCLUSION: This study confirms the nociceptive ability of these cervical synovial joints. This study may assist the clinician in the differential diagnosis of head and neck pain.

Thoracic zygapophyseal joint pain patterns. A study in normal volunteers.

STUDY DESIGN: Nine asymptomatic volunteers underwent 40 provocative intra-articular injections of the thoracic zygapophyseal joints. OBJECTIVE: The purpose of the study was to isolate and stimulate the thoracic zygapophyseal joints via fluoroscopically guided intra-articular injections to determine whether they are potential pain generators. SUMMARY OF BACKGROUND DATA: Experimentally, the cervical and lumbar zygapophyseal joints have been shown to produce pain, and tentative referral patterns have been established. Referral patterns based on stimulation of the thoracic zygapophyseal joints have not been previously reported. METHODS: Four subjects underwent right-sided T3-T4, T5-T6, T7-T8, and T9-T10 joint injections, and four subjects underwent left-sided T4-T5, T6-T7, T8-T9, and T10-T11 joint injections. One subject underwent both the right- and left-sided joint injections. The zygapophyseal joints were injected with contrast medium only, and the quality, intensity, and distribution of evoked pain was recorded. RESULTS: In this asymptomatic population, 72.5% of joints injected produced a sensation/pain that was different from the sensation of needle advancement through the soft tissues. In 27.5% of joints injected, there was no evoked pain despite adequate capsular distension. Evoked referral patterns were consistent in all subjects. Significant overlap occurred in the referral patterns, with most thoracic regions sharing 3-5 different joint referral zones. CONCLUSIONS: This study provides preliminary confirmation that the thoracic zygapophyseal joints can cause both local and referred pain. A referral pain diagram has been constructed.

The ability of lumbar medial branch blocks to anesthetize the zygapophysial joint. A physiologic challenge.

STUDY DESIGN: Randomized, controlled, single blinded study. OBJECTIVES: To determine the physiologic effectiveness of lumbar medial branch blocks. SUMMARY OF BACKGROUND DATA: Zygapophysial joint pain can be diagnosed by anesthetization of the joint or its nerve supply (the medial branch divisions of the dorsal rami). The physiologic effectiveness of lumbar medial branch blocks has been assumed but not proven. METHODS: Eighteen asymptomatic individuals were randomly assigned to either L4-L5 or L5-S1 zygapophysial joint injections with contrast medium until capsular distention elicited pain without extracapsular contrast spread. One week later, 15 blinded individuals underwent two randomized saline or 2% lidocaine medial branch injections that correlated to the innervation of the previously injected joint. Medical branch injections were performed such that inadvertent venous uptake was avoided in 14 individuals. Thirty minutes after medial branch injections, these 14 individuals underwent repeat capsular distention of the same zygapophysial joint provoked the prior week in an attempt to elicit another painful response. RESULTS: All five control individuals who received saline medial branch injections felt pain on repeat capsular distention. Nine individuals received 2% lidocaine medial branch blocks; eight felt no pain, and one felt pain on repeat capsular distention. CONCLUSIONS: There was a significant effect of 2% lidocaine (versus saline) medial branch injections on anesthetization of the zygapophysial joint when venous uptake was avoided during these injections. When properly performed, lumbar medial branch blocks successfully inhibit pain associated with capsular distention of the lumbar zygapophysial joints at a rate of 89%.

A novel approach to preemployment worker fitness evaluations in a material-handling industry.

STUDY DESIGN: Effectiveness of a pre-employment worker fitness evaluation in a sample of grocery warehouse order selectors was studied retrospectively. Implementation of the program began in March 1990 and as of September 10, 1993, 1100 prospective employees have been tested. OBJECTIVES: Identification of prospective employees with the necessary job specific physical requirements was conducted with a standardized test protocol based on job analysis and normative data. Follow-up injury rates and costs for this department were supplied by the company for statistical analysis. SUMMARY OF BACKGROUND DATA: To establish normative data for minimum standards of job performance, a control group of current, uninjured and experienced order selectors was evaluated in respect to job requirements and isokinetic variables. In the control group, 17 variables were identified including one each from two 5-minute repetitive lifting tasks with weighted crates and 15 isokinetic trunk function and lifting variables. Prospective employees were required to successfully complete at least 15 variables for hire as an order selector. METHODS: The t-test for significance of difference between two proportions was used to compare injury rates in 1989 to those reported in 1990, 1991, 1992, and 1993. RESULTS: Statistically significant differences were found between the unimplemented comparison year of 1989 and the 4 years post-implementation. CONCLUSIONS: Preliminary data suggests that a worker fitness evaluation using the above methodology may be an effective method of reducing injuries and subsequent costs.

Positive sacroiliac screening tests in asymptomatic adults.

STUDY DESIGN: In a prospective, single-blinded study, the incidence of false-positive screening tests for sacroiliac joint dysfunction was investigated using the standing flexion, seated flexion, and Gillet tests in 101 asymptomatic subjects. OBJECTIVES: This study determined if these commonly used sacroiliac screening tests can be abnormal in an asymptomatic population. SUMMARY OF BACKGROUND DATA: The sacroiliac joint is a potential source of back and leg pain. One condition affecting this joint is termed sacroiliac joint dysfunction. Diagnosis of this is made primarily by physical examination using screening tests as preliminary diagnostic tools. These screening tests evaluate for asymmetry in sacroiliac motion due to a relative, unilateral hypomobility in one the sacroiliac joints. The specificity of these tests, however, has not been thoroughly evaluated in a well-selected asymptomatic population. METHODS: A single-blinded examiner performed the standing flexion, seated flexion, and Gillet tests on all subjects. An asymptomatic and a symptomatic group were studied. RESULTS: Overall, 20% of asymptomatic individuals had positive findings in one or more of these tests. The specific percentage of false positives are reported by test, age, sex, and side. CONCLUSION: This study suggests that asymmetry in sacroiliac motion due to relative hypomobility as determined by these tests can occur in asymptomatic joints. Obviously, one should not rely solely on these tests to diagnose symptomatic sacroiliac dysfunction.

Specificity of lumbar medial branch and L5 dorsal ramus blocks. A computed tomography study.

STUDY DESIGN: A cross-sectional study. OBJECTIVES: To determine the face validity of lumbar medial branch blocks. SUMMARY OF BACKGROUND DATA: Lumbar medial branch blocks have been used increasingly to diagnose zygapophysial joint pain. The course and relations of the medial branches of the dorsal rami have been demonstrated in previous anatomic studies. What is not known is whether blocks of the medial branches anesthetize these nerves exclusively or whether they anesthetize other structures that are potential sources of pain. METHODS: In a cadaveric study, the branches of the dorsal rami were exposed. Spinal needles were placed over the nerves, and plain radiographs were taken to demonstrate the precise radiographic locations of the nerves. In the second phase of the study, healthy volunteers underwent injections of radiographic contrast over the nerves, and plain radiographs and computed tomographic images were taken. Injections were performed using different rates of injection and in two positions for each nerve. RESULTS: Radiographic contrast incorporated the medial branches of the dorsal rami in every injection. When injections were performed using the upper position, aberrant flow of contrast medium was demonstrated with extension into the epidural space or intervertebral foramina. When a position lower on the transverse process was selected, aberrant flow was very uncommon. Eight percent of injections were found to be intravenous. CONCLUSIONS: When the appropriate technique is used, medial branch blocks are target specific. To guard against false-negative responses due to intravenous up-take, contrast medium must be used before the injection of local anaesthetic.

Lumbar zygapophysial (facet) joint injections.

The lumbar zygapophysial joints are a potential cause of back and lower extremity pain. Absolute diagnosis of lumbar zygapophysial joint-mediated pain is based on selective analgesic injections of these joints or their nerve supply. The therapeutic role of zygapophysial joint injections is controversial. This contemporary concepts paper reviews the anatomy, mechanics, pathology, and diagnosis of this condition. A critical review of previous studies assessing the role of diagnostic and potentially therapeutic zygapophysial joint injection procedures is presented. The need for future studies is addressed, and current recommendations for the role of zygapophysial joint injection procedures based on this critical scientific review are provided.

The value of medical history and physical examination in diagnosing sacroiliac joint pain.

STUDY DESIGN: This prospective study evaluated the diagnostic utility of historically accepted sacroiliac joint tests. A multidisciplinary expert panel recommended 12 of the "best" sacroiliac joint tests to be evaluated against a criterion standard of unequivocal gain relief after an intra-articular injection of local anesthetic into the sacroiliac joint. OBJECTIVES: To identify a single sacroiliac joint test or ensemble of test that are sufficiently useful in diagnosing sacroiliac joint disorders to be clinically valuable. SUMMARY OF BACKGROUND DATA: No previous research has been done to evaluate any physical test of sacroiliac joint pain against an accepted criterion standard. METHODS: Historical data was obtained, and the 12 tests were performed by two examiners on 85 patients who subsequently underwent sacroiliac joint blocks. Ninety percent or more relief was considered a positive response, and less then 90% relief was considered a negative response. RESULTS: There were 45 positive and 40 negative responses. No historical feature, none of the 12 sacroiliac joint tests, and no ensemble of these 12 tests demonstrated worthwhile diagnostic value. CONCLUSION: Sacroiliac joint pain is resistant to identification by the historical and physical examination data from tests evaluated in this study.

Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain.

STUDY DESIGN: A prospective audit. OBJECTIVE: To establish the efficacy of lumbar medial branch neurotomy under optimum conditions. SUMMARY OF BACKGROUND DATA: Previous reports of the efficacy of lumbar medial branch neurotomy have been confounded by poor patient selection, inaccurate surgical technique, and inadequate assessment of outcome. METHODS: Fifteen patients with chronic low back pain whose pain was relieved by controlled, diagnostic medial branch blocks of the lumbar zygapophysial joints, underwent lumbar medial branch neurotomy. Before surgery, all were evaluated by visual analog scale and a variety of validated measures of pain, disability, and treatment satisfaction. Electromyography of the multifidus muscle was performed before and after surgery to ensure accuracy of the neurotomy. All outcome measures were repeated at 6 weeks, and 3, 6, and 12 months after surgery. RESULTS: Some 60% of the patients obtained at least 90% relief of pain at 12 months, and 87% obtained at least 60% relief. Relief was associated with denervation of the multifidus in those segments in which the medial branches had been coagulated. Prelesion electrical stimulation of the medial branch nerve with measurement of impedance was not associated with outcome. CONCLUSIONS: Lumbar medial branch neurotomy is an effective means of reducing pain in patients carefully selected on the basis of controlled diagnostic blocks. Adequate coagulation of the target nerves can be achieved by carefully placing the electrode in correct position as judged radiologically. Electrical stimulation before lesioning is superfluous in assuring correct placement of the electrode.

Incidence of intravascular uptake in lumbar spinal injection procedures.

STUDY DESIGN: Multicenter, prospective, observational study. OBJECTIVES: To document the incidence of and factors associated with intravascular uptake during lumbar spinal injection procedures. SUMMARY OF BACKGROUND DATA: In prior reports, the incidence of inadvertent intravascular needle placement during contrast-enhanced, fluoroscopically guided lumbar spinal injection procedures has been incidentally noted to range from 6.4% to 9.2%. We present the first systematic prospective documentation of intravascular uptake of contrast dye during different types of lumbar injection procedures. METHODS: Fifteen interventional spine physicians in seven centers recorded data regarding intravascular uptake during 1219 contrast-enhanced, fluoroscopically guided lumbar spinal injection procedures. RESULTS: The overall incidence of intravascular uptake during lumbar spinal injection procedures as determined by contrast enhanced fluoroscopic observation is 8.5%. Caudal and transforaminal routes have the highest rates at 10.9% and 10.8%, respectively, followed by zygapophyseal joint (6.1%), sacroiliac joint (5.3%), and translaminar (1.9%) injections. Intravascular uptake is twice as likely to occur in those patients over rather than under 50 years of age. Preinjection aspiration failed to produce a flashback of blood in 74% of cases that proved to be intravascular upon injection of contrast dye. CONCLUSION: The incidence of intravascular uptake during lumbar spinal injection procedures is approximately 8.5%. The route of injection and the age of the patient greatly affect this rate. Absence of flashback of blood upon preinjection aspiration does not predict extravascular needle placement. Contrast-enhanced, fluoroscopic guidance is recommended when doing lumbar spinal injection procedures to prevent inadvertent intravascular uptake of injectate.

[Beginning rheumatoid arthritis revealed during bronchiectasis surinfections. Value of cyclic antibiotherapy?]. / Polyarthrite rhumatoïde débutante révélée au décours de surinfections de bronchectasies. Place d'une antbiothérapie cyclique?

Incidence of symptomatic bronchiectasis (BR) occurs in around 2% in patients with late rheumatoid arthritis (RA). Its seems that the association BR-RA could be a worsening factor for outcome of RA patients. A 58-year-old woman without dry syndrome, suffering from bronchial purulence over one year was admitted to the Department of Pneumology for hemoptysis and arthritis (knees, ankles, and wrists). Three prior episodes of inflammatory articular pain had occurred after transient bronchial purulence or pneumonitis. CT-scan showed bilateral bronchiectasis. Diagnosis of early RA was proved after the third episode of bronchial purulence related to a strain of Haemophilus influenzae. A strain of Coxiella burnetii was probably responsible for one of the three bronchial surinfections. Latex and Waaler Rose tests were transiently positive during the first episode, and became positive after the third one. At that time, RA was relevant in view of ARA criteria. Cyclic prophylactic antibiotic regimens could be proposed to patients suffering from RA-BR association, in contrast to the cases of patients with isolated BR. This approach could prevent destabilization of RA and reinforce of anti-rheumatic therapy. Activation and release of cytokines (NFk-B, TNF-alpha), and/or bacterial epitopes seems to be directly responsible for the articular destabilization.

Dermatomal/segmental somatosensory evoked potential evaluation of L5/S1 unilateral/unilevel radiculopathies.

Dermatomal and segmental somatosensory evoked potentials (SEPs) have been reported to be of diagnostic utility in unilateral/unilevel L5 and S1 radiculopathies. This investigation employs history, physical examination, imaging studies, and electrodiagnostic medicine evaluations to clearly define unilateral/unilevel L5 or S1 nerve root compromise. Inclusion criteria require all of the preceding diagnostic methods to corroborate a specific nerve root lesion. Regression equation analysis for cortical P1 latencies evaluating age and height based on comparable patient and control reference populations reveals segmental and dermatomal sensitivities for L5 radiculopathies to be 70% and 50%, respectively, at 90% confidence intervals. Similar sensitivities are obtained for 2 standard deviation mean cortical P1 latencies. Side-to-side cortical P1 latency difference data reveal segmental and dermatomal sensitivities for S1 radiculopathies to be 50% and 10%, respectively, at two standard deviations. The clinical utility of both segmental and dermatomal SEPs are questionable in patients with known unilateral/unilevel L5 and S1 nerve root compromise.

The use of transdermal scopolamine to control drooling. A case report.

Drooling is a serious social handicap experienced by some neurologically impaired patients. No one method has been identified to control drooling for all patients, however, anticholinergic drugs recently have been utilized. In the case study described, transdermal scopolamine patches were found to be effective for controlling drooling in a traumatic brain-injured patient for whom more conservative methods failed. From a baseline saliva flow rate, saliva flow decreased an average of 30% with one-patch and 59% with two-patch dosing. No significant side effects were observed with treatment, and the decrease in drooling was maintained for a 4-month period. Although transdermal scopolamine may represent one acceptable facet of long-term treatment, it must be stressed that efficacy is variable across patient populations and that treatment approaches must be individualized.

MUJA: manipulation under joint anesthesia/analgesia: a treatment approach for recalcitrant low back pain of synovial joint origin.

OBJECTIVE: These four cases show how application of manipulation under joint anesthesia/analgesia (MUJA) may benefit the patient with low back pain (LBP) of synovial joint origin when prior treatment options fail. We propose that MUJA should be considered as a treatment option for those with recalcitrant synovial joint-mediated LBP. CLINICAL FEATURES: We report four cases of patients with LBP successfully treated by this protocol. These four patients were neurologically normal and suffered from lumbar zygapophyseal joint and/or sacroiliac joint mediated pain diagnosed by fluoroscopically guided, contrast enhanced, intra-articular anesthetic injections. There were various radiographic findings. INTERVENTION AND OUTCOMES: All four individuals were treated with manipulation after facilitatory intra-articular anesthetic/corticosteroid injections into lumbar zygapophyseal and/or sacroiliac joints. Some also required physical therapy interventions to resolve their LBP. CONCLUSIONS: Anecdotal success with MUJA is enticing; MUJA appears to be a viable alternative for those patients in whom traditional treatment options for LBP of synovial joint origin have failed. However, prospective, quality research is required before MUJA can be formally validated or not in the treatment of documented lumbar zygapophyseal joint and/or sacroiliac joint mediated LBP.

Low back pain and the zygapophysial (facet) joints.

A basic science and clinical review of low back pain due to the lumbar zygapophysial (facet) joints was performed based on a literature search of scientific journals and textbooks. Recent studies estimate that 15% to 40% of chronic low back pain is due to the zygapophysial joints. The histological basis for zygapophysial joint pain has been scientifically established, but the precise clinical etiology remains undetermined. There are no unique identifying features in the history, physical examination, and radiological imaging of patients with pain of lumbar zygapophysial joint origin. Spine physicians diagnose zygapophysial joint pain based on analgesic response to anesthetic injections into the zygapophysial joints or at their nerve supply. Studies on treatment of isolated zygapophysial joint pain are limited. This review summarizes current understanding of lumbar zygapophysial joint disorders while highlighting the need for additional research.

Atlanto-occipital joint pain. A report of three cases and description of an intraarticular joint block technique.

BACKGROUND AND OBJECTIVES: The atlanto-occipital (AO) joint is a true, innervated synovial joint with the potential to cause pain. METHODS: A detailed description of an AO joint injection technique is provided, as none was found on review of the literature. RESULTS: Using this technique, three illustrative cases provide preliminary evidence that intraarticular injection of the AO joint may have both diagnostic and therapeutic value for the treatment of upper cervical pain and headaches. CONCLUSIONS: Although AO joint injections may prove to be an effective adjunct to more traditional forms of conservative treatment, additional prospective studies are needed to better define the role of intraarticular AO joint injections in the diagnosis and treatment of head and neck pain.

Segmental v dermatomal somatosensory-evoked potentials. Normal intertrial variation and side-to-side comparison.

Although segmental and dermatomal somatosensory evoked potentials have been used in the diagnosis of lumbosacral radiculopathy, the unilateral or bilateral normal intertrial variation of these responses has not been investigated. Furthermore, there exists little consensus on how many sequential trials for a single nerve or dermatome are optimal and how to use the data generated from these trials. Without investigation of these basic parameters, determination of what constitutes a normal somatosensory-evoked potential (SEP) is difficult. In 29 normal subjects, the ipsilateral intertrial variations, arithmetic mean side-to-side differences and maximum potential side-to-side differences with stimulation of the superficial peroneal sensory nerve, sural nerve and L5 and S1 dermatomes with respect to P1 and N1 latencies and peak-to-peak amplitudes were investigated. Considerable ipsilateral intertrial variation was observed and side-to-side comparisons revealed a further increase in this inherent variation regarding the above measured parameters. The maximum potential side-to-side differences were even more remarkable than the mean side-to-side differences. For these results and others presented, a method of evaluating SEP parameters whereby the arithmetic mean of two sequential trials for both latency and amplitude is presented that attempts to minimize the normal, inherent variation. We also suggest an additional parameter with which to evaluate SEPs: the maximum side-to-side latency difference. Only through the use of a consistent methodology can segmental or dermatomal SEPs be utilized in a reliable diagnostic manner.