Pesquisa | BVS Violência e Saúde

1.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Karthaus, Wouter R; Iaquinta, Phillip J; Drost, Jarno; Gracanin, Ana; van Boxtel, Ruben; Wongvipat, John; Dowling, Catherine M; Gao, Dong; Begthel, Harry; Sachs, Norman; Vries, Robert G J; Cuppen, Edwin; Chen, Yu; Sawyers, Charles L; Clevers, Hans C.

Cell ; 159(1): 163-175, 2014 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-25201529

2.

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

Jenal, Mathias; Elkon, Ran; Loayza-Puch, Fabricio; van Haaften, Gijs; Kühn, Uwe; Menzies, Fiona M; Oude Vrielink, Joachim A F; Bos, Arnold J; Drost, Jarno; Rooijers, Koos; Rubinsztein, David C; Agami, Reuven.

Cell ; 149(3): 538-53, 2012 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-22502866

3.

Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation.

Caipa Garcia, Angela L; Kucab, Jill E; Al-Serori, Halh; Beck, Rebekah S S; Bellamri, Madjda; Turesky, Robert J; Groopman, John D; Francies, Hayley E; Garnett, Mathew J; Huch, Meritxell; Drost, Jarno; Zilbauer, Matthias; Arlt, Volker M; Phillips, David H.

Chem Res Toxicol ; 37(2): 234-247, 2024 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-38232180

4.

Transformation locked in a loop.

Drost, Jarno; Agami, Reuven.

Cell ; 139(4): 654-6, 2009 Nov 13.

Artigo em Inglês | MEDLINE | ID: mdl-19914159

5.

Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding.

Drost, Jarno; Clevers, Hans.

Mol Cell ; 63(3): 352-4, 2016 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-27494556

6.

Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma.

van den Boogaard, Marlinde L; Oka, Rurika; Hakkert, Anne; Schild, Linda; Ebus, Marli E; van Gerven, Michael R; Zwijnenburg, Danny A; Molenaar, Piet; Hoyng, Lieke L; Dolman, M Emmy M; Essing, Anke H W; Koopmans, Bianca; Helleday, Thomas; Drost, Jarno; van Boxtel, Ruben; Versteeg, Rogier; Koster, Jan; Molenaar, Jan J.

Proc Natl Acad Sci U S A ; 118(36)2021 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-34479993

7.

Xenograft and organoid model systems in cancer research.

Bleijs, Margit; van de Wetering, Marc; Clevers, Hans; Drost, Jarno.

EMBO J ; 38(15): e101654, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-31282586

8.

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS.

van Belzen, Ianthe A E M; Cai, Casey; van Tuil, Marc; Badloe, Shashi; Strengman, Eric; Janse, Alex; Verwiel, Eugène T P; van der Leest, Douwe F M; Kester, Lennart; Molenaar, Jan J; Meijerink, Jules; Drost, Jarno; Peng, Weng Chuan; Kerstens, Hindrik H D; Tops, Bastiaan B J; Holstege, Frank C P; Kemmeren, Patrick; Hehir-Kwa, Jayne Y.

BMC Cancer ; 23(1): 618, 2023 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-37400763

9.

The tumor microenvironment and immune targeting therapy in pediatric renal tumors.

Hont, Amy B; Dumont, Benoit; Sutton, Kathryn S; Anderson, John; Kentsis, Alex; Drost, Jarno; Hong, Andrew L; Verschuur, Arnauld.

Pediatr Blood Cancer ; 70 Suppl 2: e30110, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36451260

10.

CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia.

Schneider, Pauline; Wander, Priscilla; Arentsen-Peters, Susan T C J M; Vrenken, Kirsten S; Rockx-Brouwer, Dedeke; Adriaanse, Fabienne R S; Hoeve, Veerle; Paassen, Irene; Drost, Jarno; Pieters, Rob; Stam, Ronald W.

Int J Mol Sci ; 24(17)2023 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-37686014

11.

Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures.

Caipa Garcia, Angela L; Kucab, Jill E; Al-Serori, Halh; Beck, Rebekah S S; Fischer, Franziska; Hufnagel, Matthias; Hartwig, Andrea; Floeder, Andrew; Balbo, Silvia; Francies, Hayley; Garnett, Mathew; Huch, Meritxell; Drost, Jarno; Zilbauer, Matthias; Arlt, Volker M; Phillips, David H.

Int J Mol Sci ; 24(1)2022 Dec 29.

Artigo em Inglês | MEDLINE | ID: mdl-36614051

12.

LGR6 marks nephron progenitor cells.

van Ineveld, Ravian L; Margaritis, Thanasis; Kooiman, Berend A P; Groenveld, Femke; Ariese, Hendrikus C R; Lijnzaad, Philip; Johnson, Hannah R; Korving, Jeroen; Wehrens, Ellen J; Holstege, Frank; van Rheenen, Jacco; Drost, Jarno; Rios, Anne C; Bos, Frank L.

Dev Dyn ; 250(11): 1568-1583, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-33848015

13.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost, Jarno; van Jaarsveld, Richard H; Ponsioen, Bas; Zimberlin, Cheryl; van Boxtel, Ruben; Buijs, Arjan; Sachs, Norman; Overmeer, René M; Offerhaus, G Johan; Begthel, Harry; Korving, Jeroen; van de Wetering, Marc; Schwank, Gerald; Logtenberg, Meike; Cuppen, Edwin; Snippert, Hugo J; Medema, Jan Paul; Kops, Geert J P L; Clevers, Hans.

Nature ; 521(7550): 43-7, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25924068

14.

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Melo, Carlos A; Drost, Jarno; Wijchers, Patrick J; van de Werken, Harmen; de Wit, Elzo; Oude Vrielink, Joachim A F; Elkon, Ran; Melo, Sónia A; Léveillé, Nicolas; Kalluri, Raghu; de Laat, Wouter; Agami, Reuven.

Mol Cell ; 49(3): 524-35, 2013 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-23273978

15.

Profiling proliferative cells and their progeny in damaged murine hearts.

Kretzschmar, Kai; Post, Yorick; Bannier-Hélaouët, Marie; Mattiotti, Andrea; Drost, Jarno; Basak, Onur; Li, Vivian S W; van den Born, Maaike; Gunst, Quinn D; Versteeg, Danielle; Kooijman, Lieneke; van der Elst, Stefan; van Es, Johan H; van Rooij, Eva; van den Hoff, Maurice J B; Clevers, Hans.

Proc Natl Acad Sci U S A ; 115(52): E12245-E12254, 2018 12 26.

Artigo em Inglês | MEDLINE | ID: mdl-30530645

16.

Translational applications of adult stem cell-derived organoids.

Drost, Jarno; Clevers, Hans.

Development ; 144(6): 968-975, 2017 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-28292843

17.

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS.

Li, Li; van Breugel, Pieter C; Loayza-Puch, Fabricio; Ugalde, Alejandro Pineiro; Korkmaz, Gozde; Messika-Gold, Naama; Han, Ruiqi; Lopes, Rui; Barbera, Eric P; Teunissen, Hans; de Wit, Elzo; Soares, Ricardo J; Nielsen, Boye S; Holmstrøm, Kim; Martínez-Herrera, Dannys J; Huarte, Maite; Louloupi, Annita; Drost, Jarno; Elkon, Ran; Agami, Reuven.

Nucleic Acids Res ; 46(8): 4213-4227, 2018 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-29481642

18.

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Fumagalli, Arianna; Drost, Jarno; Suijkerbuijk, Saskia J E; van Boxtel, Ruben; de Ligt, Joep; Offerhaus, G Johan; Begthel, Harry; Beerling, Evelyne; Tan, Ee Hong; Sansom, Owen J; Cuppen, Edwin; Clevers, Hans; van Rheenen, Jacco.

Proc Natl Acad Sci U S A ; 114(12): E2357-E2364, 2017 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-28270604

19.

Hallmark discoveries in the biology of Wilms tumour.

Perotti, Daniela; Williams, Richard D; Wegert, Jenny; Brzezinski, Jack; Maschietto, Mariana; Ciceri, Sara; Gisselsson, David; Gadd, Samantha; Walz, Amy L; Furtwaengler, Rhoikos; Drost, Jarno; Al-Saadi, Reem; Evageliou, Nicholas; Gooskens, Saskia L; Hong, Andrew L; Murphy, Andrew J; Ortiz, Michael V; O'Sullivan, Maureen J; Mullen, Elizabeth A; van den Heuvel-Eibrink, Marry M; Fernandez, Conrad V; Graf, Norbert; Grundy, Paul E; Geller, James I; Dome, Jeffrey S; Perlman, Elizabeth J; Gessler, Manfred; Huff, Vicki; Pritchard-Jones, Kathy.

Nat Rev Urol ; 21(3): 158-180, 2024 03.

Artigo em Inglês | MEDLINE | ID: mdl-37848532

20.

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1.

Cornel, Annelisa M; van der Sman, Loutje; van Dinter, Jip T; Arrabito, Marta; Dunnebach, Ester; van Hoesel, Marliek; Kluiver, Thomas A; Lopes, Ana P; Dautzenberg, Noël M M; Dekker, Linde; van Rijn, Jorik M; van den Beemt, Denise A M H; Buhl, Juliane L; du Chatinier, Aimee; Barneh, Farnaz; Lu, Yuyan; Lo Nigro, Luca; Krippner-Heidenreich, Anja; Sebestyén, Zsolt; Kuball, Jurgen; Hulleman, Esther; Drost, Jarno; van Heesch, Sebastiaan; Heidenreich, Olaf T; Peng, Weng Chuan; Nierkens, Stefan.

J Immunother Cancer ; 12(3)2024 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-38519054

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