RESUMO
Twenty patients with primary malignant melanoma of the oral cavity have been described. They formed 3.9 percent of the total number of patients with malignant neoplasms of the oral cavity. The upper gingiva was most commonly affected. In this series, there were 14 male patients and 6 female patients who ranged in age from 26 to 80 years (average 58 years). The first symptom of melanoma was hyperpigmentation of the mucosa in 10 patients, tumor in 7, and pain in 3 edentulous patients with prostheses. Radical surgery was performed in 13 patients, followed by chemotherapy and radiotherapy in 9 cases. Only 1 patient survived 9 years. The remaining 12 died 11 to 18 months after radical treatment. Palliative therapy was applied in three patients, two patients were treated symptomatically, and two patients refused treatment. Early detection of melanoma is an indication for radical treatment and may increase the survival rate of patients with this disease, which is still very low.
Assuntos
Melanoma/patologia , Neoplasias Bucais/patologia , Adulto , Idoso , Erros de Diagnóstico , Feminino , Neoplasias Gengivais/diagnóstico , Neoplasias Gengivais/patologia , Neoplasias Gengivais/cirurgia , Humanos , Metástase Linfática , Masculino , Melanoma/diagnóstico , Melanoma/cirurgia , Pessoa de Meia-Idade , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/cirurgia , Neoplasias Palatinas/diagnóstico , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgia , Cuidados PaliativosRESUMO
We studied 28 bronchial adenocarcinomas (including 11 bronchiolo-alveolar carcinomas) stained for S-100 protein by the PAP technique in order to visualize dendritic cells in the neoplastic area. Dendritic cells were found in all cases varying in number from single to multiple and from region to region. Bronchiolo-alveolar carcinomas contained a similar quantity of these cells. The most numerous dendritic cells up to several scores per microscopical low-power field almost in all fragments of the tumour were found in three adenocarcinomas with numerous foci of the squamous cell metaplasia. Normal and metaplastic squamous epithelium of the bronchial mucosa did not show the presence of dendritic cells.
Assuntos
Adenocarcinoma/patologia , Neoplasias Brônquicas/patologia , Células Dendríticas/patologia , Adenocarcinoma/análise , Adenocarcinoma/ultraestrutura , Adulto , Neoplasias Brônquicas/análise , Neoplasias Brônquicas/ultraestrutura , Células Dendríticas/análise , Células Dendríticas/ultraestrutura , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas S100/análiseRESUMO
The authors have described eleven cases of tracheobronchial amyloidosis, in 6 men and 5 women with a mean age of 58.7 years. The follow-up period ranged from several month to six years. The clinical picture and histopathological changes in bronchoscopic and postmortem sections in two patients were described. In all cases immunohistochemical examinations for the presence of amyloid AA, AL, transthyretin (prealbumin) and beta 2-microglobulin were performed. In six cases the presence of transthyretin was found. The remaining reactions were negative. Resorptive giant cells reaction to amyloid was observed in 3 transthyretin positive cases and 1 transthyretin negative case. Four cases with negative amyloid in the examination for the presence of transthyretin accompanied bronchial carcinoma, all these cases were men with a mean age of 63.0 years.
Assuntos
Amiloidose/patologia , Broncopatias/patologia , Doenças da Traqueia/patologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Primary intraosseous carcinoma of the jaws is an uncommon lesion. The majority of these develop in preexisting odontogenic cysts. Three cases of primary intraosseous squamous cell carcinomas of the mandible and maxilla, with evidence of origin in the odontogenic cysts are described. The recent literature on carcinomas arising in jaws cysts is reviewed.
Assuntos
Carcinoma de Células Escamosas/etiologia , Neoplasias Maxilomandibulares/etiologia , Cistos Odontogênicos/complicações , Transformação Celular Neoplásica/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In the present study the Müller-Hermelink classification was used to analyze 39 thymomas and 4 thymic carcinomas collected over 20 years at the Chair and Department of Pathomorphology CM UJ. Our series consisted of 10 medullary thymomas (25.6%), 13 mixed (33.3%), 7 organoid (17.9%) and 9 cortical thymomas (23.0%). The mean age of the patients was 50.3 and it was the highest in patients with mixed thymomas-58.4 years and the lowest in patients with organoid thymomas-38.9 years, the difference being statistically significant. In the present series women were predominant (24:15). Myasthenia gravis was observed in 10 patients (25.6%), 5 women and 5 men, in 7 of them it was associated with cortical and organoid thymomas. Medullary, mixed and organoid thymomas were usually of lower stage (I and II), having a better prognosis than cortical thymomas and thymic carcinomas. One organoid thymoma recurring after 7 years evolved into cortical thymoma. Two thymic carcinomas were diagnosed as anaplastic, low differentiated, one as sarcomatous and one as well differentiated squamous carcinoma. The mean age of the patients was 39.7 years. The prognosis in all the patients with thymic carcinoma was poor. Based upon personal experience the authors regard the Müller-Hermelink classification as useful, easy to apply, reproducible and providing important prognostic information.
Assuntos
Carcinoma/classificação , Timoma/classificação , Neoplasias do Timo/classificação , Adulto , Idoso , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
A 45-year-old man who developed proteinuria was diagnosed as having Fabry's disease on the basis of renal histological findings and prominent decreases in alpha-galactosidase A activity in blood leukocytes.
Assuntos
Doença de Fabry/patologia , Rim/ultraestrutura , Membrana Basal/ultraestrutura , Biópsia , Citoplasma/ultraestrutura , Testes Diagnósticos de Rotina , Mesângio Glomerular/ultraestrutura , Humanos , Túbulos Renais/ultraestrutura , Masculino , Pessoa de Meia-IdadeRESUMO
Late complications after ethylene glycol intoxication in a 39 years old patient were presented. Irreversible severe renal failure and persistent symptoms of peripheral nerve system damage dominated in the clinical manifestation.
Assuntos
Etilenoglicóis/intoxicação , Falência Renal Crônica/etiologia , Doenças do Sistema Nervoso Periférico/etiologia , Adulto , Etilenoglicol , Humanos , Falência Renal Crônica/patologia , Falência Renal Crônica/terapia , Masculino , Diálise RenalRESUMO
A case of surgically treated amyloidosis of the larynx is presented. Current opinions on the structure of amyloid are given.
Assuntos
Amiloidose/diagnóstico , Neoplasias Laríngeas/diagnóstico , Adulto , Amiloidose/cirurgia , Humanos , Neoplasias Laríngeas/cirurgia , MasculinoRESUMO
The authors present a case of myoepithelioma of the palate. Frequency, treatment and pathologic diagnosis of the disease are discussed. A Polish name of the disease is suggested.
Assuntos
Mioepitelioma , Neoplasias Palatinas , Humanos , Masculino , Pessoa de Meia-Idade , Mioepitelioma/diagnóstico , Mioepitelioma/patologia , Mioepitelioma/cirurgia , Neoplasias Palatinas/diagnóstico , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgiaRESUMO
Epithelial odontogenic cyst develop either in result od peridental inflammation-radicular cyst, or in result of developmental disturbances in the course of the odontogenesis. The latter are divided into primordial and dentigerous cysts. Some odontogenic cysts are lined with squamous keratotic epithelium -ortho- or parakeratotic type. The latter is characterized by higher recurrence rate and malignant potential. Primary intraosseous carcinoma (PIOC) both keratizing and nonkeratizing might originate in keratocyst. Mucoepidermoid carcinoma and occasionally other benign and malignant sialogenic tumors might originate in keratocyst either. In addition in the jaw-bones with the odontogenic cyst or even without the cyst, squamous odontogenic tumor (SOT) can develop or so-called squamous odontogenic tumor-like proliferation in odontogenic cyst (SOT-LPOC). PIOC is a cancer of low grade malignant potential. Biology of SOT and SOT-LPOC in not elucidated yet as these are not frequently occurred lesion.
Assuntos
Transformação Celular Neoplásica/patologia , Doenças Maxilomandibulares/patologia , Cistos Odontogênicos/patologia , HumanosRESUMO
A rare case of the malignant form of Gorlin's cyst is reported in a 42-year-old woman. The neoplasm developed in the right maxilla, infiltrated the anterior wall and roof of the sinus and grew into the nasal cavity. Based upon literature data we characterized various clinical and histological forms of Gorlin's cyst (calcifying odontogenic cyst).
Assuntos
Neoplasias Maxilares/patologia , Tumores Odontogênicos/patologia , Adulto , Feminino , Humanos , Neoplasias Maxilares/diagnóstico por imagem , Tumores Odontogênicos/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Gastric carcinoids are reviewed in respect of epidemiology, histogenesis, localization, hormonal aspects and malignancy. Coexistence of gastric carcinoids and gastric carcinomas is also discussed as well as optimalization of histologic histochemical and ultrastructural diagnosis of gastric carcinoids.
Assuntos
Tumor Carcinoide/patologia , Transformação Celular Neoplásica/patologia , Neoplasias Gástricas/patologia , Tumor Carcinoide/etiologia , Mucosa Gástrica/patologia , Humanos , Neoplasias Gástricas/etiologiaRESUMO
We report a case of familial LCAT deficiency, diagnosed in a 35 year old women. The disease manifested itself by a presence of proteinuria, corneal opacities and haemolytic anaemia with target cells. Suspecion of familial LCAT deficiency was based on renal biopsy, which revealed characteristic serpiginous fibrillar deposits in electron microscopy. The diagnosis was confirmed by a marked decrease of estrified cholesterol, low HDL-cholesterol concentration, decrease of LCAT activity in serum, typical "stacked coins" picture of HDL lipoproteins in electron microscopy examination and positive familial history--diagnosis of LCAT deficiency in dialysed brother of patient.