Detalhe da pesquisa
1.
Small-molecule inhibition of the archetypal UbiB protein COQ8.
Nat Chem Biol
; 19(2): 230-238, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36302899
2.
Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition.
J Biol Chem
; 298(2): 101525, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34958800
3.
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
J Biol Chem
; 295(8): 2359-2374, 2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31896573
4.
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors.
Anal Chem
; 93(41): 13791-13799, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606255
5.
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors.
Molecules
; 26(19)2021 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34641454
6.
Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.
Mol Cell Proteomics
; 16(4 suppl 1): S263-S276, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237943
7.
Measuring Kinase Activity-A Global Challenge.
J Cell Biochem
; 118(11): 3595-3606, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28464261
8.
Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases.
J Biol Chem
; 289(16): 11111-11121, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616099
9.
Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies.
Pac Symp Biocomput
; 29: 276-290, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38160286
10.
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships.
Eur J Med Chem
; 271: 116357, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38636130
11.
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
bioRxiv
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38659941
12.
Models for the functions of Arf GAPs.
Semin Cell Dev Biol
; 22(1): 3-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20637885
13.
ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases.
J Biol Chem
; 287(47): 39538-53, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23014990
14.
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships.
bioRxiv
; 2023 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38234837
15.
Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.
ChemMedChem
; 17(12): e202200161, 2022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35403825
16.
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Mol Biol Cell
; 33(2): ar13, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34818063
17.
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036.
NPJ Breast Cancer
; 7(1): 51, 2021 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980863
18.
The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.
Mol Biol Cell
; 31(18): 2070-2091, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32614697
19.
Lyn regulates creatine uptake in an imatinib-resistant CML cell line.
Biochim Biophys Acta Gen Subj
; 1864(4): 129507, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31881245
20.
Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy.
JCI Insight
; 5(8)2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32213714