Detalhe da pesquisa
1.
Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Proc Natl Acad Sci U S A
; 113(41): E6064-E6071, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681620
2.
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Bioorg Med Chem Lett
; 21(10): 3078-83, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21459573
3.
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5158-61, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19646866
4.
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Bioorg Med Chem Lett
; 18(19): 5186-9, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790636
5.
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg Med Chem Lett
; 18(20): 5648-52, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18793847
6.
Discovery of a potent and selective aurora kinase inhibitor.
Bioorg Med Chem Lett
; 18(17): 4880-4, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678489
7.
Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 8): 686-91, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678933
8.
Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity.
Structure
; 14(3): 567-75, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16531240
9.
Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.
Biochem J
; 400(1): 105-14, 2006 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16813561
10.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat Cell Biol
; 16(11): 1069-79, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25327288
11.
Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.
Acta Crystallogr D Biol Crystallogr
; 64(Pt 9): 909-18, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18703838
12.
Mouse Aurora A: expression in Escherichia coli and purification.
Protein Expr Purif
; 54(1): 139-46, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434748
13.
Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy.
Bioorg Med Chem Lett
; 15(11): 2938-42, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911284
14.
Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use.
Biochemistry
; 43(4): 879-89, 2004 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14744130